Heparin-induced thrombocytopenia in paediatric patients – a review of the literature and a new case treated with danaparoid sodium

1999 ◽  
Vol 158 (S3) ◽  
pp. S130-S133 ◽  
Author(s):  
Oliver Ranze ◽  
Petra Ranze ◽  
Harry N. Magnani ◽  
Andreas Greinacher
Keyword(s):  
Review Of The Literature ◽  
Danaparoid Sodium ◽  
Heparin Induced Thrombocytopenia ◽  
Paediatric Patients

Acute limb ischemia in a patient with pre-fibrotic myelofibrosis complicated by heparin-induced thrombocytopenia and thrombosis – case report and systematic review of dabigatran use

VASA ◽  
2020 ◽  
pp. 1-6 ◽  
Author(s):  
Marina Di Pilla ◽  
Stefano Barco ◽  
Clara Sacco ◽  
Giovanni Barosi ◽  
Corrado Lodigiani
Keyword(s):  
Systematic Review ◽  
Case Report ◽  
Lower Limb ◽  
Limb Ischemia ◽  
Acute Limb Ischemia ◽  
Review Of The Literature ◽  
Heparin Induced Thrombocytopenia ◽  
Lower Limb Ischemia ◽  
Vein Thrombosis ◽  
Left Lower Limb

Summary: A 49-year-old man was diagnosed with pre-fibrotic myelofibrosis after acute left lower-limb ischemia requiring amputation and portal vein thrombosis. After surgery he developed heparin-induced thrombocytopenia (HIT) with venous thromboembolism, successfully treated with argatroban followed by dabigatran. Our systematic review of the literature supports the use of dabigatran for suspected HIT.

Heparin-induced Thrombocytopenia: Towards Consensus

1998 ◽  
Vol 79 (01) ◽  
pp. 1-7 ◽  
Author(s):  
Theodore Warkentin ◽  
Beng Chong ◽  
Andreas Greinacher
Keyword(s):  
Adverse Reaction ◽  
Treatment Approach ◽  
Diagnostic Testing ◽  
Optimal Treatment ◽  
Drug Induced ◽  
Danaparoid Sodium ◽  
Heparin Induced Thrombocytopenia ◽  
Thrombin Inhibition ◽  
Common Drug ◽  
Thrombotic Complications

SummaryHeparin-induced thrombocytopenia (HIT) is a drug-induced, immunoglobulin-mediated thrombocytopenic disorder that is important for at least three reasons. First, it is a relatively common drug-induced immunohematologic adverse reaction. Second, it is frequently complicated by life- and limb-threatening thrombotic complications. And third, there remains uncertainty about the optimal treatment approach for these patients. Recently, there has emerged increasing consensus on such important issues as the frequency, pathogenesis, and diagnostic testing, which we will summarize here. Further, a greater appreciation of the activation of the coagulation pathways in this syndrome indicate a rationale to treatment approaches that emphasize thrombin inhibition (eg. danaparoid sodium; hirudin and its analogues).

scholarly journals Usefulness of Danaparoid sodium in patients with Heparin-induced thrombocytopenia after cardiac surgery

2015 ◽  
Vol 4 (2) ◽  
pp. 73 ◽  
Author(s):  
Fariborz Farsad ◽  
Farzaneh Foroughinia ◽  
Kheirollah Gholami ◽  
Somayeh Ahmadi
Keyword(s):  
Cardiac Surgery ◽  
Danaparoid Sodium ◽  
Heparin Induced Thrombocytopenia

On the Prophylactic and Therapeutic Use of Danaparoid Sodium (Orgaran®) in Patients With Heparin-Induced Thrombocytopenia

2003 ◽  
Vol 9 (1) ◽  
pp. 25-32 ◽  
Author(s):  
Joachim F. Schenk ◽  
Gerhard Pindur ◽  
Bernhard Stephan ◽  
Stephan Mürsdorf ◽  
Friedrich Mertzlufft ◽  
...  
Keyword(s):  
Therapeutic Use ◽  
Danaparoid Sodium ◽  
Heparin Induced Thrombocytopenia

scholarly journals Spontaneous Heparin-Induced Thrombocytopenia Following Orthopaedic Surgery: Case Report and Review of the Literature

2017 ◽  
Vol 07 (12) ◽  
pp. 400-407
Author(s):  
Malcolm R. DeBaun ◽  
Michael A. Spinner ◽  
Michael D. Genualdi ◽  
Caroline Berube ◽  
Derek F. Amanatullah
Keyword(s):  
Case Report ◽  
Orthopaedic Surgery ◽  
Review Of The Literature ◽  
Heparin Induced Thrombocytopenia

А case of heparin-induced thrombocytopenia in a patient with a novel coronaviral infection, features of diagnosis and treatment in a naval hospital conditions

2021 ◽  
Vol 7 (3) ◽  
pp. 71-77
Author(s):  
I. D. Shapovalov ◽  
V. E. Makarchenko ◽  
O. Yu. Kartina ◽  
T. L. Belousova
Keyword(s):  
Clinical Practice ◽  
Platelet Activation ◽  
Clinical Case ◽  
Diagnosis And Treatment ◽  
Review Of The Literature ◽  
Heparin Induced Thrombocytopenia ◽  
Frequency Of Use ◽  
Life Threatening ◽  
Life Threatening Complication ◽  
Naval Hospital

The heparin-induced thrombocytopenia is a severe, potentially life-threatening complication of heparinotherpapia associated with thrombosis, develops as a result of antibody-mediated platelet activation. In the context of the SARS CoV-2 pandemic, the frequency of use of heparin in clinical practice has significantly increased, as a result of which the doctors have become more likely to face this complication. The article presents a review of the literature, describes the pathogenesis, modern algorithms for diagnosis and treatment, demonstrates a clinical case of heparin-induced thrombocytopenia in a patient with the SARS CoV-2, and discusses the features of diagnosis and treatment of this complication in a naval hospital.

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