ABC Transporter Genes Involved in Multidrug Resistance in Penicillium digitatum

2001 ◽  
Vol 67 (3) ◽  
pp. 251-251 ◽  
Author(s):  
Ryoji NAKAUNE
Keyword(s):  
Multidrug Resistance ◽  
Abc Transporter ◽  
Penicillium Digitatum ◽  
Abc Transporter Genes

Family business: the multidrug-resistance related protein (MRP) ABC transporter genes in Arabidopsis thaliana

Planta ◽  
2002 ◽  
Vol 216 (1) ◽  
pp. 107-119 ◽  
Author(s):  
Üner Kolukisaoglu ◽  
Lucien Bovet ◽  
Markus Klein ◽  
Thomas Eggmann ◽  
Markus Geisler ◽  
...  
Keyword(s):  
Arabidopsis Thaliana ◽  
Multidrug Resistance ◽  
Abc Transporter ◽  
Family Business ◽  
Related Protein ◽  
Abc Transporter Genes ◽  
Multidrug Resistance Related Protein

ABC Transporter Inhibitors in Reversing Multidrug Resistance to Chemotherapy

2015 ◽  
Vol 16 (12) ◽  
pp. 1356-1371 ◽  
Author(s):  
Haigang Cui ◽  
Anna Zhang ◽  
Mingwei Chen ◽  
Johnson Liu
Keyword(s):  
Multidrug Resistance ◽  
Abc Transporter ◽  
Resistance To Chemotherapy

5030 POSTER Expression Profile of ABC Transporter Genes in Breast Carcinoma

2011 ◽  
Vol 47 ◽  
pp. S339-S340
Author(s):  
V. Hlavac ◽  
R. Vaclavikova ◽  
M. Ehrlichova ◽  
I. Hlavata ◽  
V. Pecha ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Abc Transporter ◽  
Expression Profile ◽  
Abc Transporter Genes

scholarly journals Insecticide Exposure Triggers a Modulated Expression of ABC Transporter Genes in Larvae of Anopheles gambiae s.s.

Insects ◽  
2019 ◽  
Vol 10 (3) ◽  
pp. 66 ◽  
Author(s):  
Valentina Mastrantonio ◽  
Marco Ferrari ◽  
Agata Negri ◽  
Tommaso Sturmo ◽  
Guido Favia ◽  
...  
Keyword(s):  
Anopheles Gambiae ◽  
Abc Transporter ◽  
Abc Transporters ◽  
Molecular Mechanisms ◽  
Expression Profiles ◽  
Larval Mortality ◽  
Expression Patterns ◽  
Main Tool ◽  
Gene Expression Response ◽  
Abc Transporter Genes

Insecticides remain a main tool for the control of arthropod vectors. The urgency to prevent the insurgence of insecticide resistance and the perspective to find new target sites, for the development of novel molecules, are fuelling the study of the molecular mechanisms involved in insect defence against xenobiotic compounds. In this study, we have investigated if ATP-binding cassette (ABC) transporters, a major component of the defensome machinery, are involved in defence against the insecticide permethrin, in susceptible larvae of the malaria vector Anopheles gambiae sensu stricto. Bioassays were performed with permethrin alone, or in combination with an ABC transporter inhibitor. Then we have investigated the expression profiles of five ABC transporter genes at different time points following permethrin exposure, to assess their expression patterns across time. The inhibition of ABC transporters increased the larval mortality by about 15-fold. Likewise, three genes were up-regulated after exposure to permethrin, showing different patterns of expression across the 48 h. Our results provide the first evidences of ABC transporters involvement in defence against a toxic in larvae of An. gambiae s.s. and show that the gene expression response is modulated across time, being continuous, but stronger at the earliest and latest times after exposure.

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