Endogenous central histamine-induced reversal of critical haemorrhagic hypotension in rats – studies with histamine N-methyltransferase inhibitor SKF 91488

2002 ◽  
Vol 51 (11) ◽  
pp. 551-556 ◽  
Author(s):  
J. Jochem
1984 ◽  
Vol 4 (1) ◽  
pp. 107-109 ◽  
Author(s):  
E. Shohami ◽  
A. Sidi

The effect of haemorrhagic hypotension on the levels of prostaglandin E2 (PGE2), thromboxane B2 (TXB2), and 6-keto prostaglandin F1α (6-keto-PGF1α) in cortical tissue of rats was studied. Lightly anesthetized rats were subjected to steady-state hypotension for 15 min, with a mean arterial blood pressure of 80, 60, and 40 mm Hg, and compared to a control group of normotensive rats. No significant change was found in the levels of PGE2 and TXB2. The level of 6-keto-PGF1α increased from 7.8 ± 0.9 to 14.1 ± 1.9 pg/mg protein (p < 0.02) at 80 mm Hg. Our findings suggest that prostacyclin, which is a potent vasodilator, might play a role in setting the lower limit of the autoregulation range.


1972 ◽  
Vol 28 (3) ◽  
pp. 241-246 ◽  
Author(s):  
J. P. LAVENDER ◽  
THOMAS SHERWOOD ◽  
SUSAN RUSSELL

1974 ◽  
Vol 4 (4) ◽  
pp. 229-234
Author(s):  
P. Sandoz ◽  
A. Grandchamp ◽  
B. Truniger

1987 ◽  
Vol 129 (4) ◽  
pp. 479-487 ◽  
Author(s):  
K. OLSSON ◽  
N.-E. ANDÉN ◽  
K. JOHANSSON ◽  
U. THORNSTRÖM

1992 ◽  
Vol 448 (1) ◽  
pp. 437-452 ◽  
Author(s):  
P O Iversen ◽  
H B Benestad ◽  
G Nicolaysen

1994 ◽  
Vol 83 (3) ◽  
pp. 236-240 ◽  
Author(s):  
A Bairam ◽  
B Hannhart ◽  
F Marchal

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