Inhibition of antigen-induced arthritis in guinea pigs by a selective LTB4 receptor antagonist LY293111Na

2002 ◽  
Vol 51 (11) ◽  
pp. 541-550 ◽  
Author(s):  
K. Kuwabara ◽  
H. Jyoyama ◽  
J. H. Fleisch ◽  
Y. Hori
Keyword(s):  
Receptor Antagonist ◽  
Guinea Pigs ◽  
Ltb4 Receptor

The guinea pig as a suitable species for the characterization of the LTB4 receptor antagonist ZK 158252

1998 ◽  
Vol 16 ◽  
pp. S211
Author(s):  
Claudia Giesen ◽  
Bernd Buchmann ◽  
Roland Ekerdt ◽  
Wolfgang Fröhlich ◽  
Josef Heindl ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Receptor Antagonist ◽  
Ltb4 Receptor

A 5-HT4 agonist mosapride enhances rectorectal and rectoanal reflexes in guinea pigs

2003 ◽  
Vol 285 (2) ◽  
pp. G389-G395 ◽  
Author(s):  
Hidehiko Shimatani ◽  
Yu Kojima ◽  
Makoto Kadowaki ◽  
Tadashi Nakagawa ◽  
Hisao Fujii ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Receptor Antagonist ◽  
Strain Gauge ◽  
Guinea Pigs ◽  
Internal Anal Sphincter ◽  
Pressure Transducer ◽  
Force Transducer ◽  
Rectal Distension ◽  
Pelvic Nerves ◽  
Strain Gauge Force Transducer

The rectal distension-evoked reflex rectal (R-R) contractions and internal anal sphincter (R-IAS) relaxations in guinea pigs were generated through the extrinsic sacral excitatory nerve pathway (pelvic nerves) and the intrinsic cholinergic excitatory and nitrergic inhibitory nerve pathways. The aim of the present study was to evaluate whether a prokinetic benzamide, mosapride, enhances the R-R and R-IAS reflexes mediated via 5-HT4 receptors in the guinea pig. The mechanical activities of the R and IAS were recorded with a balloon connected to a pressure transducer and a strain gauge force transducer in the anesthetized guinea pig with intact spinal-intestinal pathways. Gradual and sustained rectal distension evoked R-R contractions and synchronous R-IAS relaxations. Mosapride (0.1–1.0 mg/kg iv) dose-dependently enhanced both R-R and R-IAS reflex responses. Reflex indexes for R-R and R-IAS maximally increased from 1.0 (control) to 1.92 and 1.88, respectively. A specific 5-HT4 receptor antagonist, GR 113808 (1.0 mg/kg iv), antagonized the enhancement of the R-R and R-IAS reflexes induced by mosapride 1.0 mg/kg iv. The present results indicate that mosapride enhanced the R-R and R-IAS reflexes mediated through 5-HT4 receptors.

The non-pfjptide NK-1 receptor antagonist LY303870 inhibits neurogenic dural inflammation in guinea pigs

Life Sciences ◽  
1997 ◽  
Vol 60 (18) ◽  
pp. 1553-1561 ◽  
Author(s):  
Lee A. Phebus ◽  
Kirk W. Johnson ◽  
Peter W. Stengel ◽  
Karen L. Lobb ◽  
James A. Nixon ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Guinea Pigs

scholarly journals Antithrombotic Effects of KW-3635, a Thromboxane A2-Receptor Antagonist, in Guinea Pigs.

1994 ◽  
Vol 65 (2) ◽  
pp. 93-98 ◽  
Author(s):  
Shiro Shirakura ◽  
Katsuya Higo ◽  
Masami Takeda ◽  
Akira Karasawa
Keyword(s):  
Receptor Antagonist ◽  
Guinea Pigs ◽  
Thromboxane A2 ◽  
Thromboxane A2 Receptor ◽  
Antithrombotic Effects

scholarly journals Antithrombotic Effects of KW-3635, a Thromboxane A2-Receptor Antagonist, in Guinea Pigs

1994 ◽  
Vol 65 (2) ◽  
pp. 93-98
Author(s):  
Shiro Shirakura ◽  
Katsuya Higo ◽  
Masami Takeda ◽  
Akira Karasawa
Keyword(s):  
Receptor Antagonist ◽  
Guinea Pigs ◽  
Thromboxane A2 ◽  
Thromboxane A2 Receptor ◽  
Antithrombotic Effects

Dopamine D1 receptor antagonist inhibits swallowing reflex in guinea pigs

1998 ◽  
Vol 274 (1) ◽  
pp. R76-R80 ◽  
Author(s):  
Yu Xia Jia ◽  
Kiyohisa Sekizawa ◽  
Takashi Ohrui ◽  
Katsutoshi Nakayama ◽  
Hidetada Sasaki
Keyword(s):  
Receptor Antagonist ◽  
Guinea Pigs ◽  
Sch 23390 ◽  
Specific Inhibitor ◽  
Visual Observation ◽  
D1 Receptor ◽  
Electromyographic Activity ◽  
Distilled Water ◽  
Peripheral Organs ◽  
Swallowing Reflex

To determine whether dopamine D1receptor antagonist impairs the swallowing reflex and reduces substance P (SP) in the peripheral organs, the swallowing reflex in terms of the number of swallows elicited by injections of three different volumes (0.2, 0.4, and 0.6 ml) of distilled water into the pharynx through a catheter was examined in anesthetized guinea pigs pretreated with Sch-23390. Animals were pretreated with either subcutaneous Sch-23390 (200 μg/kg) or a vehicle of Sch-23390 every 12 h for 7 days. The number of swallows was counted by submental electromyographic activity and visual observation of characteristic laryngeal movement. Injections of distilled water caused a volume-dependent increase in the number of swallows in animals without Sch-23390 treatment. Sch-23390 significantly decreased and exogenously administered SP increased the number of swallows elicited by all volumes of distilled water. FK-888 (10−5 M, 1 ml), a specific inhibitor of the NK1 receptor, reduced the number of swallows to a greater degree than Sch-23390. Sch-23390 significantly reduced SP content in the laryngeal and pharyngeal mucosa compared with control. These results suggest that inhibition of the dopamine D1 receptor may impair the swallowing reflex and reduce SP content in the peripheral organs.

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