scholarly journals Methacholine Dose-Response Slopes from Maximal Bronchial Challenge Tests in Asthmatic Children: Methodological Aspects

Lung ◽  
1997 ◽  
Vol 175 (4) ◽  
pp. 243-252
Author(s):  
T. Gamboa ◽  
N. Neuparth ◽  
I. Ribeiro da Silva ◽  
J. E. Rosado Pinto ◽  
A. B. Rendas
Keyword(s):  
Dose Response ◽  
Bronchial Challenge ◽  
Asthmatic Children ◽  
Challenge Tests ◽  
Methodological Aspects

scholarly journals ERS technical standard on bronchial challenge testing: pathophysiology and methodology of indirect airway challenge testing

2018 ◽  
Vol 52 (5) ◽  
pp. 1801033 ◽  
Author(s):  
Teal S. Hallstrand ◽  
Joerg D. Leuppi ◽  
Guy Joos ◽  
Graham L. Hall ◽  
Kai-Håkon Carlsen ◽  
...  
Keyword(s):  
Airway Hyperresponsiveness ◽  
Task Force ◽  
Challenge Test ◽  
Technical Standard ◽  
Bronchial Challenge ◽  
Airway Narrowing ◽  
Airway Function ◽  
Challenge Testing ◽  
Challenge Tests ◽  
Indirect Tests

Recently, this international task force reported the general considerations for bronchial challenge testing and the performance of the methacholine challenge test, a “direct” airway challenge test. Here, the task force provides an updated description of the pathophysiology and the methods to conduct indirect challenge tests. Because indirect challenge tests trigger airway narrowing through the activation of endogenous pathways that are involved in asthma, indirect challenge tests tend to be specific for asthma and reveal much about the biology of asthma, but may be less sensitive than direct tests for the detection of airway hyperresponsiveness. We provide recommendations for the conduct and interpretation of hyperpnoea challenge tests such as dry air exercise challenge and eucapnic voluntary hyperpnoea that provide a single strong stimulus for airway narrowing. This technical standard expands the recommendations to additional indirect tests such as hypertonic saline, mannitol and adenosine challenge that are incremental tests, but still retain characteristics of other indirect challenges. Assessment of airway hyperresponsiveness, with direct and indirect tests, are valuable tools to understand and to monitor airway function and to characterise the underlying asthma phenotype to guide therapy. The tests should be interpreted within the context of the clinical features of asthma.

scholarly journals Spirometry and mannitol bronchial challenge test among firefighters in Bhuj district: a questionnaire based study

2017 ◽  
Vol 4 (5) ◽  
pp. 1434
Author(s):  
Kashyap Buch ◽  
Vinayak Chauhan
Keyword(s):  
Nitric Oxide ◽  
Lung Disease ◽  
Chronic Lung Disease ◽  
Respiratory Symptoms ◽  
Challenge Test ◽  
Shortness Of Breath ◽  
Chest Tightness ◽  
Bronchial Challenge ◽  
Challenge Tests ◽  
Skin Prick Tests

Background: Asthma is a common chronic lung disease that inflames and narrows the airways. It causes recurring period of wheezing, chest tightness, shortness of breath and coughing.Methods: A questionnaire, spirometry, direct and indirect airway challenge tests, exhaled nitric oxide, and skin-prick tests were administered prospectively to 100 out of 120 firefighters employed in Bhuj district, Gujarat, India. Asthma was defined as the combination of respiratory symptoms with airway hyper responsiveness.Results: Twenty out of 100 firefighters (12%) had physician-diagnosed asthma, which could be confirmed in 8 firefighters. In contrast, asthma was diagnosed in 28% (28 of 100 firefighters). Wheezing was the most sensitive symptom for the diagnosis of asthma (sensitivity, 88%; specificity, 90%).Conclusions: Asthma was considerably under diagnosed in firefighters. The combination of a structured symptom questionnaire with a bronchial challenge test allows identifying patients with asthma and should routinely be used in the assessment of active firefighters and may be of help when evaluating candidates for this profession.

Efficacy and Safety of Methacholine Bronchial Challenge Performed by Auscultation in Young Asthmatic Children

2000 ◽  
Vol 162 (3) ◽  
pp. 857-860 ◽  
Author(s):  
CHAIM SPRINGER ◽  
SIMON GODFREY ◽  
ELIE PICARD ◽  
KAMAL UWYYED ◽  
MOSHE ROTSCHILD ◽  
...  
Keyword(s):  
Efficacy And Safety ◽  
Bronchial Challenge ◽  
Asthmatic Children

287 Albuterol MDI cumulative dose-response in asthmatic children

1996 ◽  
Vol 97 (1) ◽  
pp. 254-254
Author(s):  
F FERRARI ◽  
N ROSARIO ◽  
O KANTOR ◽  
L KOVALHUK ◽  
L CALEFFE
Keyword(s):  
Cumulative Dose ◽  
Dose Response ◽  
Asthmatic Children

Terbutaline in asthmatic children: A dose-response study

1978 ◽  
Vol 93 (2) ◽  
pp. 305-307 ◽  
Author(s):  
Bjorn Ardal ◽  
Pierre Beaudry ◽  
A.H. Eisen
Keyword(s):  
Dose Response ◽  
Asthmatic Children ◽  
Dose Response Study
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