Pretreatment with topical all-trans-retinoic acid is beneficial for wound healing in genetically diabetic mice

2001 ◽  
Vol 293 (10) ◽  
pp. 515-521 ◽  
Author(s):  
Y. Kitano ◽  
K. Yoshimura ◽  
G. Uchida ◽  
K. Sato ◽  
K. Harii
Keyword(s):  
Wound Healing ◽  
Retinoic Acid ◽  
Diabetic Mice ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid ◽  
Genetically Diabetic Mice

Effects of all-trans retinoic acid nanoparticles on corneal epithelial wound healing

2011 ◽  
Vol 250 (4) ◽  
pp. 557-563 ◽  
Author(s):  
Masako Hattori ◽  
Kazuhiro Shimizu ◽  
Kozo Katsumura ◽  
Hidehiro Oku ◽  
Yoichiro Sano ◽  
...  
Keyword(s):  
Wound Healing ◽  
Retinoic Acid ◽  
Corneal Epithelial ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid ◽  
Epithelial Wound Healing

All-trans retinoic acid suppresses bone morphogenetic protein 4 in mouse diabetic nephropathy through a unique retinoic acid response element

2019 ◽  
Vol 316 (3) ◽  
pp. E418-E431 ◽  
Author(s):  
Masanori Tamaki ◽  
Tatsuya Tominaga ◽  
Yui Fujita ◽  
Yasuhiko Koezuka ◽  
Go Ichien ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Retinoic Acid ◽  
Regulatory Mechanism ◽  
Bone Morphogenetic Protein 4 ◽  
Diabetic Mice ◽  
Mesangial Matrix ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid ◽  
Morphogenetic Protein ◽  
Matrix Expansion

Diabetic nephropathy (DN) causes mesangial matrix expansion, which results in glomerulosclerosis and renal failure. Collagen IV (COL4) is a major component of the mesangial matrix that is positively regulated by bone morphogenetic protein 4 (BMP4)/suppressor of mothers against decapentaplegic (Smad1) signaling. Because previous studies showed that retinoids treatment had a beneficial effect on kidney disease, we investigated the therapeutic potential of retinoids in DN, focusing especially on the regulatory mechanism of BMP4. Diabetes was induced with streptozotocin in 12-wk-old male Crl:CD1(ICR) mice, and, 1 mo later, we initiated intraperitoneal injection of all-trans retinoic acid (ATRA) three times weekly. Glomerular matrix expansion, which was associated with increased BMP4, phosphorylated Smad1, and COL4 expression, worsened in diabetic mice at 24 wk of age. ATRA administration alleviated DN and downregulated BMP4, phosopho-Smad1, and COL4. In cultured mouse mesangial cells, treatment with ATRA or a retinoic acid receptor-α (RARα) agonist significantly decreased BMP4 and COL4 expression. Genomic analysis suggested two putative retinoic acid response elements (RAREs) for the mouse Bmp4 gene. Chromatin immunoprecipitation analysis and reporter assays indicated a putative RARE of the Bmp4 gene, located 11,488–11,501 bp upstream of exon 1A and bound to RARα and retinoid X receptor (RXR), which suppressed BMP4 expression after ATRA addition. ATRA suppressed BMP4 via binding of a RARα/RXR heterodimer to a unique RARE, alleviating glomerular matrix expansion in diabetic mice. These findings provide a novel regulatory mechanism for treatment of DN.

All-trans retinoic acid promotes wound healing of primary amniocytes through the induction of LOXL4, a member of the lysyl oxidase family

2016 ◽  
Vol 81 ◽  
pp. 10-19 ◽  
Author(s):  
Marion Rouzaire ◽  
Aurélie Comptour ◽  
Corinne Belville ◽  
Damien Bouvier ◽  
Gaël Clairefond ◽  
...  
Keyword(s):  
Wound Healing ◽  
Retinoic Acid ◽  
Lysyl Oxidase ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid

Antiproliferative effect of all-trans-retinoic acid in cholangiocarcinoma

2017 ◽  
Author(s):  
A Prawan ◽  
S Butsri ◽  
V Kukongviriyapan ◽  
L Senggunprai ◽  
S Kongpetch
Keyword(s):  
Retinoic Acid ◽  
Antiproliferative Effect ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid
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