Vitamin D and Estrogen Receptor Polymorphisms and Bone Mineral Changes in Postpartum Women

2000 ◽  
Vol 66 (3) ◽  
pp. 184-189 ◽  
Author(s):  
D. Holmberg-Marttila ◽  
H. Sievänen ◽  
T. L. N. Järvinen ◽  
T. A. H. Järvinen
Gene ◽  
2014 ◽  
Vol 537 (1) ◽  
pp. 10-14 ◽  
Author(s):  
David Rojano-Mejía ◽  
Ramón Mauricio Coral-Vázquez ◽  
Agustín Coronel ◽  
Leticia Cortes-Espinosa ◽  
María del Carmen Aguirre-García ◽  
...  

2019 ◽  
Vol 32 (12) ◽  
pp. 1377-1384
Author(s):  
Işıl İnan-Erdoğan ◽  
Sinem Akgül ◽  
Kübra Işgın-Atıcı ◽  
Tuğba Tuğrul-Yücel ◽  
Koray Boduroğlu ◽  
...  

Abstract Background Anorexia nervosa (AN) is a serious eating disorder that is associated with decreased bone mineral density (BMD) and greater lifetime risk for fractures. The aim of this study was to determine the correlation between BMD and genetic polymorphisms in AN. Methods This case-control study analyzed vitamin D receptor (VDR) (VDRBsml, VDRFokl) and estrogen receptor (ESR) (ESR1Xbal, ESR1Pvull) polymorphisms in 45 adolescents diagnosed with AN and 46 age-matched healthy controls. BMD values of the AN group were classified as low or normal, and polymorphisms were compared between cases and controls. The effects of body mass index (BMI), duration of disease and amenorrhea on BMD were also evaluated. Results In girls with AN, a positive effect of the bb genotype of VDRBsmI polymorphism on femur Z-scores (p = 0.103) and of the Ff genotype of VDRFokI polymorphism on vertebra Z-scores (p = 0.097) was observed. In boys with AN, a positive effect of the Ff genotype of VDRFokI polymorphism on vertebra BMD (g/cm2) was detected (p = 0.061). No association was detected between ESR polymorphisms. An inverse relationship was observed between BMD and duration of illness and amenorrhea. A direct relationship was detected between BMD and BMI. Conclusions Specific VDR gene polymorphism genotypes may have positive effects on BMD in patients with AN. Additionally, the lack of association between ESR gene polymorphisms on BMD could be attributed to the low estrogen status of the patient.


PLoS ONE ◽  
2017 ◽  
Vol 12 (3) ◽  
pp. e0173045 ◽  
Author(s):  
Ieva Martinaityte ◽  
Rolf Jorde ◽  
Nina Emaus ◽  
Anne Elise Eggen ◽  
Ragnar Martin Joakimsen ◽  
...  

2010 ◽  
Vol 29 (11) ◽  
pp. 1285-1293 ◽  
Author(s):  
Mine Durusu Tanriover ◽  
Gamze Bora Tatar ◽  
Tenzile Deniz Uluturk ◽  
Didem Dayangac Erden ◽  
Altug Tanriover ◽  
...  

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Ravi Rangarajan ◽  
Surajit Mondal ◽  
Prashanth Thankachan ◽  
Ramananda Chakrabarti ◽  
Anura V. Kurpad

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