Thalamic and temporal cortex input to medial prefrontal cortex in rhesus monkeys

1997 ◽  
Vol 115 (3) ◽  
pp. 430-444 ◽  
Author(s):  
Jocelyne Bachevalier ◽  
M. Meunier ◽  
M. X. Lu ◽  
Leslie G. Ungerleider
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Rhesus Monkeys ◽  
Temporal Cortex

scholarly journals Early and late neural correlates of mentalizing: ALE meta-analyses in adults, children and adolescents

2021 ◽  
Author(s):  
Lynn V Fehlbaum ◽  
Réka Borbás ◽  
Katharina Paul ◽  
Simon b Eickhoff ◽  
Nora m Raschle
Keyword(s):  
Prefrontal Cortex ◽  
Children And Adolescents ◽  
Medial Prefrontal Cortex ◽  
Temporal Cortex ◽  
Mental States ◽  
Brain Regions ◽  
Inferior Temporal Cortex ◽  
Temporoparietal Junction ◽  
Right Temporoparietal Junction ◽  
Meta Analyses

Abstract The ability to understand mental states of others is referred to as mentalizing and enabled by our Theory of Mind. This social skill relies on brain regions comprising the mentalizing network as robustly observed in adults but also in a growing number of developmental studies. We summarized and compared neuroimaging evidence in children/adolescents and adults during mentalizing using coordinate-based activation likelihood estimation meta-analyses to inform about brain regions consistently or differentially engaged across age categories. Adults (N = 5286) recruited medial prefrontal and middle/inferior frontal cortices, precuneus, temporoparietal junction and middle temporal gyri during mentalizing, which were functionally connected to bilateral inferior/superior parietal lobule and thalamus/striatum. Conjunction and contrast analyses revealed that children and adolescents (N = 479) recruit similar but fewer regions within core mentalizing regions. Subgroup analyses revealed an early continuous engagement of middle medial prefrontal cortex, precuneus and right temporoparietal junction in younger children (8–11 years) and adolescents (12–18 years). Adolescents additionally recruited the left temporoparietal junction and middle/inferior temporal cortex. Overall, the observed engagement of the medial prefrontal cortex, precuneus and right temporoparietal junction during mentalizing across all ages reflects an early specialization of some key regions of the social brain.

scholarly journals Early continuity in neuronal correlates of mentalizing: ALE meta-analyses in adults, children and youths

2020 ◽  
Author(s):  
Lynn V. Fehlbaum ◽  
Réka Borbás ◽  
Katharina Paul ◽  
Nora Maria Raschle
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Temporal Cortex ◽  
Brain Regions ◽  
Inferior Temporal Cortex ◽  
Social Brain ◽  
Temporoparietal Junction ◽  
Middle Temporal ◽  
Right Temporoparietal Junction ◽  
Meta Analyses

The ability to understand mental states of others is known as Theory of Mind or mentalizing. Neuroimaging studies in adults have reported activation increases in medial prefrontal, inferior frontal, temporoparietal cortices and precuneus during mentalizing. In children/youths, activation in some areas of this social brain network are suggested to develop early, while other areas mature later. We compared neuroimaging evidence in children/youths and adults during mentalizing using coordinate-based activation likelihood estimation meta-analyses to inform about brain regions consistently or differentially engaged across age. Healthy adults (N=5286) recruited medial prefrontal and middle/inferior frontal cortices, precuneus, temporoparietal junction and middle temporal gyri during mentalizing, which were functionally connected to bilateral inferior/superior parietal lobule and thalamus/striatum. Children and youths (N=479) recruited similar, but fewer regions, including temporoparietal junction, precuneus, medial prefrontal and middle temporal cortices. Subgroup analyses revealed an early continuous engagement of middle medial prefrontal cortex, precuneus and right temporoparietal junction in children (8–11y) and youths (12–18y). Youths additionally recruited the left temporoparietal junction and middle/inferior temporal cortex. Overall, the observed continuous engagement of the medial prefrontal cortex, precuneus and right temporoparietal junction during mentalizing across all ages reflects an early specialization of some of the key social brain regions.

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