YM90K, an AMPA receptor antagonist, protects against ischemic damage caused by permanent and transient middle cerebral artery occlusion in rats

1998 ◽  
Vol 358 (5) ◽  
pp. 586-591 ◽  
Author(s):  
S. Kawasaki-Yatsugi ◽  
Chikako Ichiki ◽  
Shin-ichi Yatsugi ◽  
Masao Shimizu-Sasamata ◽  
Tokio Yamaguchi
Keyword(s):  
Middle Cerebral Artery ◽  
Receptor Antagonist ◽  
Middle Cerebral Artery Occlusion ◽  
Ampa Receptor ◽  
Cerebral Artery ◽  
Artery Occlusion ◽  
Ischemic Damage ◽  
Ampa Receptor Antagonist ◽  
Cerebral Artery Occlusion

Neuroprotective effects of an AMPA receptor antagonist YM872 in a rat transient middle cerebral artery occlusion model

2000 ◽  
Vol 39 (2) ◽  
pp. 211-217 ◽  
Author(s):  
Sachiko Kawasaki-Yatsugi ◽  
Chikako Ichiki ◽  
Shin-ichi Yatsugi ◽  
Masayasu Takahashi ◽  
Masao Shimizu-Sasamata ◽  
...  
Keyword(s):  
Middle Cerebral Artery ◽  
Receptor Antagonist ◽  
Middle Cerebral Artery Occlusion ◽  
Ampa Receptor ◽  
Cerebral Artery ◽  
Artery Occlusion ◽  
Neuroprotective Effects ◽  
Ampa Receptor Antagonist ◽  
Occlusion Model ◽  
Cerebral Artery Occlusion

A novel AMPA receptor antagonist, YM872, reduces infarct size after middle cerebral artery occlusion in rats

1998 ◽  
Vol 793 (1-2) ◽  
pp. 39-46 ◽  
Author(s):  
Sachiko Kawasaki-Yatsugi ◽  
Shin-ichi Yatsugi ◽  
Masayasu Takahashi ◽  
Takashi Toya ◽  
Chikako Ichiki ◽  
...  
Keyword(s):  
Infarct Size ◽  
Middle Cerebral Artery ◽  
Receptor Antagonist ◽  
Middle Cerebral Artery Occlusion ◽  
Ampa Receptor ◽  
Cerebral Artery ◽  
Artery Occlusion ◽  
Ampa Receptor Antagonist ◽  
Cerebral Artery Occlusion

scholarly journals Neuroprotective Effect of the AMPA Receptor Antagonist LY-293558 in Focal Cerebral Ischemia in the Cat

1994 ◽  
Vol 14 (3) ◽  
pp. 466-471 ◽  
Author(s):  
R. Bullock ◽  
D. I. Graham ◽  
S. Swanson ◽  
J. McCulloch
Keyword(s):  
Cerebral Ischemia ◽  
Middle Cerebral Artery ◽  
Receptor Antagonist ◽  
Ampa Receptor ◽  
Cerebral Artery ◽  
Focal Cerebral Ischemia ◽  
Neuroprotective Effect ◽  
Ischemic Damage ◽  
Physiological Variables ◽  
Ampa Receptor Antagonist

The effects of the glutamate α-amino-3-hydroxy 5-methyl-4-isoxazole propionate (AMPA) receptor antagonist LY-293558 in reducing ischemic brain damage have been assessed in halothane-anesthetized cats. Focal cerebral ischemia was produced by permanent occlusion of one middle cerebral artery, and the animals were killed 6 h later. The amount of early irreversible ischemic damage was assessed at 16 predetermined stereotactic planes by an observer blinded to treatment paradigm employed. Treatment with LY-293558 (15 mg/kg i.v., plus infusion of 7 mg/kg/h) initiated 30 min prior to middle cerebral artery occlusion reduced significantly (p < 0.02) the volume of ischemic damage (from 3,423 ± 212 mm3 of the cerebral hemisphere in vehicle-treated cats to 2,822 ± 569 mm3 in LY-293558-treated cats). The present data demonstrate that an AMPA receptor antagonist can reduce focal ischemic damage in a gyrencephalic species in which key physiological variables have been controlled and monitored throughout the postischemic period. These data provide additional support for the clinical evaluation of AMPA receptor antagonists in focal cerebral ischemia in humans.

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