The relaxing effect of BDF 9148 on the KCl-contracted aorta isolated from normo- and hyper-tensive rats

1998 ◽  
Vol 357 (2) ◽  
pp. 126-132 ◽  
Author(s):  
S. A. Doggrell ◽  
Ling C. Liang
Keyword(s):  
Bdf 9148 ◽  
Relaxing Effect

The relaxing effect of SCH 23390 in the molluscan smooth muscle

1989 ◽  
Vol 94 (1) ◽  
pp. 341-344
Author(s):  
Hajime Murakami ◽  
Masakazu Sano ◽  
Takashi Tsukimura ◽  
Akira Yamazaki
Keyword(s):  
Smooth Muscle ◽  
Sch 23390 ◽  
Molluscan Smooth Muscle ◽  
Relaxing Effect

scholarly journals MAG-EPA reduces severity of DSS-induced colitis in rats

2016 ◽  
Vol 310 (10) ◽  
pp. G808-G821 ◽  
Author(s):  
Caroline Morin ◽  
Pierre U. Blier ◽  
Samuel Fortin
Keyword(s):  
Therapeutic Potential ◽  
Combined Treatment ◽  
Neutrophil Infiltration ◽  
Antagonistic Effect ◽  
Omega 3 ◽  
Strong Activity ◽  
Tnf Α ◽  
Biochemical Analyses ◽  
Relaxing Effect

Ulcerative colitis (UC) is a chronic disease characterized by diffuse inflammation of the intestinal mucosa of the large bowel. Omega-3 (ω3) fatty acid supplementation has been associated with a decreased production of inflammatory cytokines involved in UC pathogenesis. The aim of this study was to determine the preventive and therapeutic potential of eicosapentaenoic acid monoglyceride (MAG-EPA) in an in vivo rats model of UC induced by dextran sulfate sodium (DSS). DSS rats were untreated or treated per os with MAG-EPA. Morphological, histological, and biochemical analyses were performed following MAG-EPA administrations. Morphological and histological analyses revealed that MAG-EPA pretreatment (12 days pre-DSS) and treatment (6 days post-DSS) exhibited strong activity in reducing severity of disease in DSS rats. Following MAG-EPA administrations, tissue levels of the proinflammatory cytokines TNF-α, IL-1β, and IL-6 were markedly lower compared with rats treated only with DSS. MAG-EPA per os administration decrease neutrophil infiltration in colon tissues, as depicted by myelohyperoxidase activity. Results also revealed a reduced activation of NF-κB pathways correlated with a decreased expression of COX-2 in colon homogenates derived from MAG-EPA-pretreated and treated rats. Tension measurements performed on colon tissues revealed that contractile responses to methacholine and relaxing effect induced by sodium nitroprusside were largely increased following MAG-EPA treatment. The combined treatment of MAG-EPA and vitamin E displayed an antagonistic effect on anti-inflammatory properties of MAG-EPA in DSS rats.

scholarly journals Aromatherapy Versus Pharmaceutical Interventions for Dementia Related Behaviors Translating & Integrating Scholarship Practicum

2018 ◽  
Vol 3 (1) ◽  
Keyword(s):  
Side Effects ◽  
Psychotropic Drugs ◽  
Elderly Population ◽  
The Elderly ◽  
Safe Alternative ◽  
Pharmaceutical Management ◽  
Diagnosis Of Dementia ◽  
Number Of Individuals ◽  
Relaxing Effect ◽  
Pharmaceutical Interventions

The elderly population is expected to double in the next thirty years increasing the number of individuals with the diagnosis of dementia. By proxy, dementia related behaviors such as agitation, anxiety and restless will also increase. Currently, pharmaceutical management of these behaviors include Ativan, Haldol and other psychotropic drugs which have side effects that place individuals at risk for falls and at times even aggravate the behaviors. Although, not widely researched, aromatherapy is a safe alternative to treating Dementia related behaviors. Research shows aromatherapy has a calming and relaxing effect which can be measured physiologically.

Abstract 276: Heme Oxygenase-1 Induction Modulates Hypoxic Pulmonary Vasoconstriction

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Mansoor Ahmad ◽  
Nader G Abraham ◽  
Michael S Wolin
Keyword(s):  
Organ Culture ◽  
Heme Oxygenase ◽  
Cobalt Chloride ◽  
Hypoxic Pulmonary Vasoconstriction ◽  
Pulmonary Arteries ◽  
Heme Oxygenase 1 ◽  
Force Development ◽  
Pulmonary Vasoconstriction ◽  
Copper Chelator ◽  
Relaxing Effect

Endothelium removed Bovine pulmonary arteries (BPA) contract to hypoxia through a mechanism potentially involving lowering of superoxide-derived hydrogen peroxide and removing its basal relaxing effect. Induction of heme oxygenase-1 (HO-1) in BPA by 24 hr organ culture with 0.1mM cobalt chloride was accompanied by a decrease in 5μM lucigenin-detectable superoxide and an increase in horseradish peroxidase-luminol detectable peroxide levels. Force development to 20mM KCl in BPA was not affected by HO-1, but hypoxic pulmonary vasoconstriction (HPV) was significantly reduced. Organ culture with a HO-1 inhibitor (10μM chromium mesoporphyrin) reversed the effects of HO-1 on HPV and peroxide. Pretreatment of BPA with a copper chelator 10mM diethyldithiocarbamate (DETCA) to inactivate Cu,Zn-SOD, prevented the conversion of superoxide to peroxide, and attenuated HPV. DETCA treatment increased superoxide and decreased peroxide to similar levels in control and HO-1 induced BPA. Peroxide scavenging with 0.1mM ebselen increased force development to 20mM KCl and partially reversed the decrease in HPV seen on induction of HO-1. Thus HO-1 induction in BPA causes an increase in superoxide scavenging by Cu,Zn-SOD resulting in increased levels of peroxide, leading to an attenuation of HPV. The generation of superoxide in BPA is not affected by HO-1 induction as DETCA treated control and HO-1 BPA show similar levels of superoxide. Thus, HO-1 induction appears to attenuate HPV in BPA by increasing the conversion of superoxide to peroxide, leading to peroxide levels which may not be adequately lowered by hypoxia.

scholarly journals Relaxing Effect Induced by Forest Sound in Patients with Gambling Disorder

2020 ◽  
Vol 12 (15) ◽  
pp. 5969
Author(s):  
Hiroko Ochiai ◽  
Chorong Song ◽  
Hyunju Jo ◽  
Masayuki Oishi ◽  
Michiko Imai ◽  
...  
Keyword(s):  
Heart Rate ◽  
Gambling Disorder ◽  
Near Infrared ◽  
Subjective Evaluation ◽  
Sound Waves ◽  
High Definition ◽  
Psychological Reactions ◽  
Japanese Male ◽  
Nervous Function ◽  
Relaxing Effect

The number of people addicted to gambling has increased worldwide. They often suffer from debilitating medical conditions associated with stress or depression. This study examined the physiological and psychological reactions of gambling disorder (GD) patients while listening to high-definition forest or city sounds using headphones. In total, 12 Japanese male GD patients were exposed to high-definition forest or city sound waves for 1 min via headphones. Near-infrared spectroscopy of the prefrontal cortex was used to examine oxyhemoglobin (oxy-Hb) concentrations. Heart rate and heart rate variability are indicators of autonomic nervous function. We performed subjective evaluation via the modified version of the semantic differential (SD) method with the profiles of the mood states (POMS). Experiencing forest sounds led to substantial differences as opposed to listening to city sounds: (1) oxy-Hb levels of the bilateral prefrontal cortices were lower (2) the modified SD method resulted in increased comfortable and relaxed feelings, (3) the negative POMS subscale scores were significantly lower, indicating that negative emotions diminished markedly when patients listened to forest sounds. This is the first study to show that sounds of forest relaxed individuals physiologically and psychologically to minimize GD.

Beta-adrenergic relaxation of smooth muscle: differences between cells and tissues

1987 ◽  
Vol 253 (3) ◽  
pp. C369-C374 ◽  
Author(s):  
C. R. Scheid
Keyword(s):  
Smooth Muscle ◽  
Stomach Muscle ◽  
Isolated Cells ◽  
Beta Adrenergic ◽  
Adrenergic Agents ◽  
Smooth Muscle Function ◽  
45Ca Efflux ◽  
Toad Bufo ◽  
Relaxing Effect ◽  
Isolated Smooth Muscle Cells

The present studies were carried out in an attempt to resolve the controversy about the Na+ dependence of beta-adrenergic relaxation in smooth muscle. Previous studies on isolated smooth muscle cells from the toad stomach had suggested that at least some of the actions of beta-adrenergic agents, including a stimulatory effect on 45Ca efflux, were dependent on the presence of a normal transmembrane Na+ gradient. Studies by other investigators using tissues derived from mammalian sources had suggested that the relaxing effect of beta-adrenergic agents was Na+ independent. Uncertainty remained as to whether these discrepancies reflected differences between cells and tissues or differences between species. Thus, in the present studies, we utilized both tissues and cells from the same source, the stomach muscle of the toad Bufo marinus, and assessed the Na+ dependence of beta-adrenergic relaxation. We found that elimination of a normal Na+ gradient abolished beta-adrenergic relaxation of isolated cells. In tissues, however, similar manipulations had no effect on relaxation. The reasons for this discrepancy are unclear but do not appear to be attributable to changes in smooth muscle function following enzymatic dispersion. Rather they may be attributable to unique properties of tissues, such as the presence of pacemaker cells, nerves, and so on. Thus the controversy concerning the mechanism of beta-adrenergic relaxation may reflect inherent differences between tissues and cells.

Comparison of the Relaxing Effect of Dopamine with that of Adenosine, Isoproterenol and Acetylcholine in Isolated Canine Coronary Arteries

1975 ◽  
Vol 12 (5) ◽  
pp. 290-301
Author(s):  
Noboru Toda ◽  
Masakazu Hojo ◽  
Koichiro Sakae ◽  
Hachiro Usui
Keyword(s):  
Coronary Arteries ◽  
Relaxing Effect

Inotropic actions of BDF 9148 and DPI 201-106 and their enantiomers in guinea-pig, rat and human atria

1993 ◽  
Vol 231 (3) ◽  
pp. 477-480 ◽  
Author(s):  
Andrew Hoey ◽  
Anke Lehmkuhl ◽  
Volker Sadony ◽  
Ursula Ravens
Keyword(s):  
Guinea Pig ◽  
Bdf 9148

Influence of Indomethacin on the Systemic and Pulmonary Vascular Resistance in Man

1978 ◽  
Vol 54 (2) ◽  
pp. 141-145 ◽  
Author(s):  
Å. Wennmalm
Keyword(s):  
Pulmonary Vascular Resistance ◽  
Systemic Vascular Resistance ◽  
Vascular Resistance ◽  
Systemic Blood Pressure ◽  
Total Oxygen ◽  
Related Substances ◽  
Blood Pressures ◽  
Pulmonary Arterial ◽  
Oxygen Difference ◽  
Relaxing Effect

1. Indomethacin, an inhibitor of the cyclo-oxygenase system that converts arachidonic acid into prostaglandins and related substances, was infused intravenously in 12 healthy volunteer subjects. 2. Systemic systolic and diastolic blood pressures and heart rate were recorded in all subjects, and in most of them also the systemic arteriovenous oxygen difference, the total oxygen uptake and the pulmonary arterial and wedge pressures. 3. The infusion of indomethacin was followed by a decreased cardiac output (from 7·3 ± 0·3 to 6·3 ± 0·3 litres/min) and an increased mean systemic blood pressure (from 92 ± 1 to 102 ± 1 mmHg), indicating an elevation of the total systemic vascular resistance (from 98 ± 4 to 124 ± 5 kPa)l−1 s) by indomethacin. The ventilation and the pulmonary vascular resistance did not change after the infusion of indomethacin. 4. The results suggest that products formed by the cyclo-oxygenase system at rest exert a relaxing effect in certain parts of the systemic vascular bed, thereby lowering the systemic vascular resistance.

Sign in / Sign up

Export Citation Format

Share Document