Capsaicin-sensitive local sensory innervation is involved in pacing-induced preconditioning in rat hearts: role of nitric oxide and CGRP?

1997 ◽  
Vol 356 (3) ◽  
pp. 356-363 ◽  
Author(s):  
P. Ferdinandy ◽  
Tamás Csont ◽  
Csaba Csonka ◽  
Marianna Török ◽  
Mária Dux ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Sensory Innervation ◽  
Rat Hearts

scholarly journals The Effect of Mitochondrial Complex I-Linked Respiration by Isoflurane Is Independent of Mitochondrial Nitric Oxide Production

2018 ◽  
Vol 8 (2) ◽  
pp. 113-122 ◽  
Author(s):  
Fuqi Xu ◽  
Shigang Qiao ◽  
Hua Li ◽  
Yanjun Deng ◽  
Chen Wang ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Mitochondrial Respiration ◽  
Complex I ◽  
Adenosine Diphosphate ◽  
Sprague Dawley ◽  
No Donor ◽  
Anesthetic Preconditioning ◽  
Rat Hearts ◽  
Nos Inhibitor

Background: Anesthetic preconditioning (APC) of the myocardium is mediated in part by reversible alteration of mitochondrial function. Nitric oxide (NO) inhibits mitochondrial respiration and may mediate APC-induced cardioprotection. In this study, the effects of isoflurane on different states of mitochondrial respiration during the oxidation of complex I-linked substrates and the role of NO were investigated. Methods: Mitochondria were isolated from Sprague-Dawley rat hearts. Respiration rates were measured polarographically at 28ºC with a computer-controlled Clark-type O2 electrode in the mitochondria (0.5 mg/mL) with complex I substrates glutamate/malate (5 mM). Isoflurane (0.25 mM) was administered before or after adenosine diphosphate (ADP)-initiated state 3 respiration. The NO synthase (NOS) inhibitor L-N5-(1-iminoethyl)-ornithine (L-NIO, 10 μM) and the NO donor S-nitroso-N-acetylpenicillamine (SNAP, 1 μM) were added before or after the addition of ADP. Results: Isoflurane administered in state 2 increased state 2 respiration and decreased state 3 respiration. This attenuation of state 3 respiration by isoflurane was similar when it was given during state 3. L-NIO did not alter mitochondrial respiration or the effect of isoflurane. SNAP only, added in state 3, decreased state 3 respiration and enhanced the isoflurane-induced attenuation of state 3 respiration. Conclusion: Isoflurane has clearly distinguishable effects on different states of mitochondrial respiration during the oxidation of complex I substrates. The uncoupling effect during state 2 respiration and the attenuation of state 3 respiration may contribute to the mechanism of APC-induced cardioprotection. These effects of isoflurane do not depend on endogenous mitochondrial NO, as the NOS inhibitor L-NIO did not alter the effects of isoflurane on mitochondrial respiration.

Role of endogenous nitric oxide in classic preconditioning in rat hearts

2007 ◽  
Vol 139 (1-3) ◽  
pp. 141-145 ◽  
Author(s):  
María G. Marina Prendes ◽  
Marcela González ◽  
Enrique A. Savino ◽  
Alicia Varela
Keyword(s):  
Nitric Oxide ◽  
Rat Hearts ◽  
Endogenous Nitric Oxide

scholarly journals Role of nitric oxide synthases in the infarct size-reducing effect conferred by heat stress in isolated rat hearts

2001 ◽  
Vol 132 (8) ◽  
pp. 1845-1851 ◽  
Author(s):  
Claire Arnaud ◽  
Aline Laubriet ◽  
Marie Joyeux ◽  
Diane Godin-Ribuot ◽  
Luc Rochette ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Heat Stress ◽  
Infarct Size ◽  
Nitric Oxide Synthases ◽  
Rat Hearts ◽  
Isolated Rat

Role of enzymes involved in nitric oxide and superoxide metabolism in ischemic late preconditioning in rat hearts

2006 ◽  
Vol 40 (6) ◽  
pp. 976
Author(s):  
Péter Bencsik ◽  
Gabriella Fodor ◽  
Zoltán Giricz ◽  
Tamás Csont ◽  
Péter Ferdinandy
Keyword(s):  
Nitric Oxide ◽  
Late Preconditioning ◽  
Rat Hearts

scholarly journals ROLE OF OXYGEN IN NITRIC OXIDE RELEASE ON HYPOXIA-REOXYGENATION IN ISOLATED RAT HEARTS

1997 ◽  
Vol 75 ◽  
pp. 82
Author(s):  
Ikuo Taniguchi ◽  
Michiko Kobayashi ◽  
Taro Date ◽  
Masayuki Taniguchi ◽  
Seibu Mochizuki
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Release ◽  
Rat Hearts ◽  
Isolated Rat ◽  
Hypoxia Reoxygenation

Role of nitric oxide in the reperfusion induced injury in hyperthyroid rat hearts

2000 ◽  
Vol 32 (5) ◽  
pp. 411-421 ◽  
Author(s):  
Piero Masullo ◽  
Paola Venditti ◽  
Claudio Agnisola ◽  
Sergio Di Meo
Keyword(s):  
Nitric Oxide ◽  
Rat Hearts

Loss of Pacing-induced Preconditioning in Rat Hearts: Role of Nitric Oxide and Cholesterol-enriched Diet

1997 ◽  
Vol 29 (12) ◽  
pp. 3321-3333 ◽  
Author(s):  
Péter Ferdinandy ◽  
Zoltán Szilvássy ◽  
László I. Horváth ◽  
Tamás Csont ◽  
Csaba Csonka ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Rat Hearts

A critical role of iNOS-derived Nitric Oxide (NO) and progesterone in implantation

1998 ◽  
Vol 5 (1) ◽  
pp. 115A-115A
Author(s):  
K CHWALISZ ◽  
E WINTERHAGER ◽  
T THIENEL ◽  
R GARFIELD
Keyword(s):  
Nitric Oxide ◽  
Critical Role
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