New Directions in Diagnosis and Treatment of Pericardial Disease A Project of the Taskforce on Pericardial Disease of the World Heart Federation

Herz ◽  
2000 ◽  
Vol 25 (8) ◽  
pp. 769-780 ◽  
Author(s):  
Bernhard Maisch ◽  
Arsen D. Ristić ◽  
Petar M. Seferovic
2019 ◽  
Vol 48 (4) ◽  
pp. 7-16 ◽  
Author(s):  
Noura Erakat ◽  
Marc Lamont Hill

This introductory essay outlines the context for this special issue of the Journal of Palestine Studies on Black-Palestinian transnational solidarity (BPTS). Through the analytic of “renewal,” the authors point to the recent increase in individual and collective energies directed toward developing effective, reciprocal, and transformative political relationships within various African-descendant and Palestinian communities around the world. Drawing from the extant BPTS literature, this essay examines the prominent intellectual currents in the field and points to new methodologies and analytics that are required to move the field forward. With this essay, the authors aim not only to contextualize the field and to frame this special issue, but also to chart new directions for future intellectual and political work.


2020 ◽  
Vol 48 (7) ◽  
pp. 648-655
Author(s):  
Yu Han ◽  
Mengnan Li ◽  
Huijing Ma ◽  
Hailan Yang

AbstractCervical insufficiency (CI) is a mainly disease leading to recurrent abortions and preterm birth which may present in about 1% of obstetric populations. Recurrent pregnancy losses caused by CI incur serious economic burdens on society as well as huge psychological burdens to family members. However, many patients even clinicians in some areas of the world still remain confused about this disease. At the same time, the etiology of CI is still uncertain and it is still a controversial disease in diagnosis and treatment. This article summarizes the potential risk factors associated with CI, which could be worthy of attention and helpful for future research. It also reviews the methods for diagnosis and treatment of CI to better understand this noteworthy disease, as well as presents the related consensus and controversies according to the newly updated guidelines, which has practical significance for conducting more in-depth investigations in the future.


2020 ◽  
Vol 11 (2.ESP) ◽  
Author(s):  
Maria Soraya Pereira Franco Adriano ◽  
Betânia Maria Pereira Santos ◽  
Carmem Gabriela Gomes de Figueiredo Figueiredo ◽  
Ana Carolina Bernardes Dulgheroff ◽  
Ronaldo Rodrigues Sarmento ◽  
...  

Objetivo: Analisar a produção científica acerca da atual pandemia do novo coronavírus, destacando aspectos referentes às características do vírus, bem como a epidemiologia, o diagnóstico e tratamento da COVID-19 no intuito de fornecer informações aos profissionais de saúde e à comunidade científica. Método: Revisão narrativa, com busca nas bases de dados Scielo, Medline, Lilacs e Pubmed, referente ao período de fevereiro a maio de 2020, utilizando os descritores: “infecções por coronavírus” or “coronavirus infections”, “COVID-19”, “betacoronavirus”, “Síndrome Respiratória Aguda Grave”, “SARS-Cov-2”, “diagnóstico”, “diagnosis”. Resultados: Foram evidenciadas três categorias temáticas: aspectos referentes ao vírus; a epidemiologia e a clínica da doença; e aspectos do diagnóstico e tratamento. Conclusão: O Coronavírus sofreu mutações desde o início da pandemia, mas não se sabe se estas mutações afetaram seu poder de infecciosidade. Em diferentes partes do mundo a epidemiologia da COVID-19 foi diferente. Com relação ao tratamento, a droga que tem se mostrado mais promissora até o momento é o remdesivir. Sem uma vacina eficaz, a maior arma que dispomos é o isolamento social.Descritores: Infecções por Coronavírus; COVID-19; Síndrome Respiratória Aguda Grave. SEVERE ACUTE RESPIRATORY SYNDROME AND COVID-19 (SARS-COV-2): A NARRATIVE REVIEWObjective: To analyze a scientific production on the current pandemic of new coronaviruses, highlighting aspects related to virus resources, as well as the epidemiology, diagnosis and treatment of COVID-19 in order to provide information to health professionals and the scientific community. Method: Narrative review, searching the Scielo, Medline, Lilacs and Pubmed databases, for the period from February to May 2020, using the keywords: "coronavirus infections" or "coronavirus infections", "COVID-19", "Betacoronavirus", "Severe Acute Respiratory Syndrome", "SARS-Cov-2", "diagnosis", "diagnosis". Results: Three thematic categories were highlighted: aspects related to the virus; an epidemiology and disease clinic; and aspects of diagnosis and treatment. Conclusion: The Coronavirus has mutated since the beginning of the pandemic, but it is not known whether these mutations have affected its infectiousness. In different parts of the world the epidemiology of COVID-19 was different. Regarding treatment, a drug that has been shown to be more promising until recovery is needed. Without an effective vaccine, the biggest weapon that affects social isolation.Descriptors: Coronavirus Infections; COVID-19; Severe Acute Respiratory Syndrome. SÍNDROME RESPIRATORIO AGUDO GRAVE Y COVID-19 (SARS-COV-2): UNA REVISIÓN NARRATIVAObjetivo: analizar una producción científica sobre la pandemia actual de nuevos coronavirus, destacando aspectos relacionados con los recursos del virus, así como la epidemiología, diagnóstico y tratamiento de COVID-19 para proporcionar información a los profesionales de la salud y la comunidad científica. Método: Revisión narrativa, buscando en las bases de datos Scielo, Medline, Lilacs y Pubmed, para el período de febrero a mayo de 2020, utilizando los descriptores: "infecciones por coronavirus" o "infecciones por coronavirus", "COVID-19", "Betacoronavirus", "Síndrome respiratorio agudo severo", "SARS-Cov-2", "diagnóstico", "diagnóstico". Resultados: se destacaron tres categorías temáticas: aspectos relacionados con el virus; una clínica de epidemiología y enfermedad; y aspectos de diagnóstico y tratamiento. Conclusión: el coronavirus ha mutado desde el comienzo de la pandemia, pero no se sabe si estas mutaciones han afectado su infecciosidad. En diferentes partes del mundo, la epidemiología de COVID-19 fue diferente. Con respecto al tratamiento, un medicamento que ha demostrado ser más prometedor hasta que se necesita recuperación. Sin una vacuna efectiva, el arma más grande que afecta el aislamiento social.Descriptores: Infecciones por Coronavirus; COVID-19; Síndrome Respiratorio Agudo Severo.


2011 ◽  
Vol 17 (2) ◽  
pp. 639-644 ◽  
Author(s):  
Daniel C. Baumgart ◽  
Charles N. Bernstein ◽  
Zaigham Abbas ◽  
Jean F. Colombel ◽  
Andrew S. Day ◽  
...  

Religions ◽  
2021 ◽  
Vol 12 (11) ◽  
pp. 991
Author(s):  
John Powers

By the twelfth century, a broad consensus had developed among Tibetan Buddhists: The Middle Way School (Madhyamaka) of Nāgārjuna (c. 2nd century), as interpreted by Candrakīrti (c. 600–650), would be normative in Tibet. However, Tibetans had inherited various trajectories of commentary on Madhyamaka, and schools of thought developed, each with a particular reading. This article will examine some of the major competing philosophical stances, focusing on three figures who represent particularly compelling interpretations, but whose understandings of Madhyamaka are profoundly divergent: Daktsang Sherap Rinchen (1405–1477), Wangchuk Dorjé, the 9th Karmapa (1556–1603), and Purchok Ngawang Jampa (1682–1762). The former two contend that Nāgārjuna’s statement “I have no thesis” (nāsti ca mama pratijñā) means exactly what it says, while the latter advocates what could be termed an “anthropological” approach: Mādhyamikas, when speaking as Mādhyamikas, only report what “the world” says, without taking any stance of their own; but their understanding of Buddhism is based on insight gained through intensive meditation training. This article will focus on how these three philosophers figure in the history of Tibetan Madhyamaka exegesis and how their respective readings of Indic texts incorporate elements of previous work while moving interpretation in new directions.


Blood ◽  
2019 ◽  
Vol 134 (Supplement_1) ◽  
pp. 2173-2173
Author(s):  
Arwa Fraiwan ◽  
Muhammad Noman Hasan ◽  
Ran An ◽  
Amy J. Rezac ◽  
Nicholas J. Kocmich ◽  
...  

Nigeria leads the world in the number of cases of sickle cell disease (SCD). An estimated 150,000 babies are born annually in Nigeria with SCD, a heredity disorder, and 70-90% die before age 5. Only a small portion of affected infants and children in sub Saharan Africa (SSA) reach adolescence. Over 650 children die per day in sub-Saharan Africa from SCD. These dismal statistics are in sharp contrast to outcomes in high-income countries (HICs) where more than 90% of SCD patients reach adulthood. The World Health Organization (WHO) estimates that 70% of deaths could be prevented with a low cost diagnostic and treatment plan. Meaningful preventive care and treatment cannot be implemented without a structured plan for early diagnosis and patient tracking.Early diagnosis requires improved access to parents and guardians of children with SCD, and gaining this access remains a challenge in most of SSA. In 2015, Nigeria's Kano state government, with support from foreign partners, established a community-based program for newborn registration. This platform provides unique access to newborn babies in one of Nigeria's most populous cities, but still lacks a functioning patient testing, tracking, and monitoring system, which we plan to address in our ongoing study. This study will introduce mobile health in a low-income country with low literacy rate and hopefully accustom that segment of the population to more varied mobile health applications that will ultimately improve their health in the long run. Our current operational platform in Kano, Nigeria provides access to a large population with a high prevalence of SCD. We have previously completed pilot testing of 315 subjects for SCD using our microchip electrophoresis test. We are planning to test up to 4,500 additional subjects less than 5 years of age at Murtala Muhammed Specialist Hospital. The hospital staff includes 97 physicians and 415 nurses and outpatient clinics serve about 30,000 patients monthly. The maternity department has a 200-bed capacity and the antenatal clinic performs about 1,000 deliveries and serves an average of 3,000 mothers monthly. Enrollment is planned to start on September 15, 2019 and medical staff are currently being trained to run the tests. Our study is registered in the United States National Library of Medicine's ClinicalTrials.gov (Identifier: NCT03948516). Our technology is uniquely paired with an automatic reader and an Electronic Medical Record (EMR) and patient management solution to record POC test results, register new cases, and track patients for follow-up (Fig. 1). The reader enables automated interpretation of test results, local and remote test data storage, and includes geolocation (Global Positioning System) (Fig. 2). The system will generate reports for all cases of SCD, track hospital visits, appointments, lab tests, and will have mobile and dashboard applications for tracking patients and samples. The application will be installed on mobile devices provided to users. The proposed system will be compliant with the existing privacy standards to handle medical data (e.g., HIPAA in the US and GDPR in the EU). All communications between the parties will be secured via end-to-end encryption as a safeguard. We anticipate that our project will increase the rates of screening, diagnosis and timely treatment of SCD in Kano State of Nigeria. The project's broader impact will likely be the ability to track and monitor screening, disease detection, diagnosis and treatment, which can be scaled up to the whole nation of Nigeria, then to sub-Saharan Africa. The data obtained and analyzed will be the first of their kind and will be used to inform the design of programs to improve access to, and availability of, effective care for this underserved populations. The importance of increased access to diagnosis and treatment should not be underestimated - it is crucial for realizing effective management of people with SCD. The impact can be enhanced by complementing diagnosis and patient tracking with education for the families so they can provide or seek the necessary preventative treatment. Identification of the location of the patients in need would help identify the areas where family, parent, caregiver education should be provided. Disclosures Fraiwan: Hemex Health, Inc.: Equity Ownership, Patents & Royalties. Hasan:Hemex Health, Inc.: Equity Ownership, Patents & Royalties. An:Hemex Health, Inc.: Patents & Royalties. Thota:Hemex Health, Inc.: Employment. Gurkan:Hemex Health, Inc.: Consultancy, Employment, Equity Ownership, Patents & Royalties, Research Funding.


1991 ◽  
Vol 67 (4) ◽  
pp. 790-791
Author(s):  
Mina Toksöz

2018 ◽  
Vol 78 (05) ◽  
pp. 469-480
Author(s):  
Michael Untch ◽  
Rachel Würstlein ◽  
Norbert Marschner ◽  
Diana Lüftner ◽  
Doris Augustin ◽  
...  

AbstractThe fourth international advanced breast cancer consensus conference (ABC4) on the diagnosis and treatment of advanced breast cancer (ABC) headed by Professor Fatima Cardoso was once again held in Lisbon on November 2 – 4, 2017. To simplify matters, the abbreviation ABC will be used hereinafter in the text. In clinical practice, the abbreviation corresponds to metastatic breast cancer or locally far-advanced disease. This year the focus was on new developments in the treatment of ABC. Topics discussed included the importance of CDK4/6 inhibition in hormone receptor (HR)-positive ABC, the use of dual antibody blockade to treat HER2-positive ABC, PARP inhibition in triple-negative ABC and the potential therapeutic outcomes. Another major area discussed at the conference was BRCA-associated breast cancer, the treatment of cerebral metastasis, and individualized treatment decisions based on molecular testing (so-called precision medicine). As in previous years, close cooperation with representatives from patient organizations from around the world is an important aspect of the ABC conference. This cooperation was reinforced and expanded at the ABC4 conference. A global alliance was founded at the conclusion of the consensus conference, which aims to promote and coordinate the measures considered necessary by patient advocates worldwide. Because the panel of experts was composed of specialists from all over the world, it was inevitable that the ABC consensus also reflected country-specific features. As in previous years, a team of German breast cancer specialists who closely followed the consensus voting of the ABC panelists in Lisbon and intensively discussed the votes has therefore commented on the consensus in the context of the current German guidelines on the diagnosis and treatment of breast cancer 1, 2 used in clinical practice in Germany. The ABC consensus is based on the votes of the ABC panelists in Lisbon.


1950 ◽  
Vol 4 (3) ◽  
pp. 400-411 ◽  
Author(s):  
Lincoln Palmer Bloomfield

The United Nations at the time of this writing has emerged from a period of uncertainty engendered by the Soviet boycotts beginning in January 1950, into blazing prominence as a fast-acting agency for suppressing armed aggression. Many of the questions raised during the first four years of its existence concerning its vitality and effectiveness as the center of a collective security system have now been dramatically answered. Its forms have altered with experience, and by analogy to our Constitution, its action in response to the armed invasion of the Republic of Korea constitutes a precedent which may rank with Chief Justice Marshall's most momentous decisions. Whatever new directions the organization and its Charter may take in response to the dynamics of the world society they represent, it is indisputable that this new parlimentary form of conducting international affairs has conclusively proved its worth and its indispensability to the future of the international community.


1969 ◽  
Vol 68 (272) ◽  
pp. 232-244 ◽  
Author(s):  
DAVID GORDON

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