Induced sputum of patients with chronic obstructive pulmonary disease (COPD) contains adhesion-promoting, therapy-sensitive factors

2000 ◽  
Vol 49 (1) ◽  
pp. 8-13 ◽  
Author(s):  
F. J. van Overveld ◽  
P. A. Vermeire ◽  
W. A. De Backer
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Induced Sputum ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease

scholarly journals Eosinophilic Airway Inflammation in Patients with Stable Biomass Smoke- versus Tobacco Smoke-Associated Chronic Obstructive Pulmonary Disease

2019 ◽  
Vol 9 (24) ◽  
Author(s):  
Lalita Fernandes ◽  
Shraddha Rane ◽  
Suresh Mandrekar ◽  
Anthony Menezes Mesquita
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Tobacco Smoke ◽  
Induced Sputum ◽  
Biomass Fuel ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Biomass Smoke ◽  
Severity Of Disease ◽  
Inflammatory Profile

Background. Chronic obstructive pulmonary disease (COPD) is an inflammatory disease with predominant involvement of neutrophils, macrophages and CD8+ lymphocytes. Eosinophilic airway inflammations are reported in stable state and during acute exacerbations of tobacco smoke-associated COPD (TS-COPD). Women exposed to biomass fuel smoke are known to have eosinophils in sputum. However, little is known about the sputum cellular inflammatory profile in biomass fuel smoke-associated COPD (BMS-COPD). We therefore aimed to compare the sputum cellular inflammatory profile in tobacco smoke- and biomass smoke-associated COPD. Methods. The study was conducted in a tertiary care hospital in Goa, India. A total of 113 patients with stable COPD reporting to the outpatient pulmonary clinic were recruited. All participants were ≥ 40 years of age. Sputum induction studies were performed by the method of Pizzichini et al. after baseline subject characterization. Significant eosinophilia was defined as induced sputum eosinophils ≥ 3%. Results. There were 85 TS-COPD and 28 BMS-COPD patients. The mean age [standard deviation (SD)] was 64.7 (7.8) and 63.0 years (8.3), p = 0.32 in TS and BMS-COPD, respectively. Eighteen subjects (21.1%) were female smokers. The smoking pack-year median [interquartile range (IQR)] was 36 (20, 58) and hour-years of biomass smoke exposure mean (SD) was 192.4 (61). The TS-COPD and BMS-COPD cases showed a post-bronchodilator forced expiratory volume in one second (FEV1%) mean (SD) of 57.9 (17.1), and 62.6 (19.4), p= 0.22, respectively. Both groups had similar symptoms and severity of disease. Induced sputum total cell count per gram of sputum × 106 mean (SD) was 3.05 (1.53) for TS-COPD, and 2.55(1.37) for BMS-COPD p=0.12. The neutrophils % mean (SD) was 86.4 (16.5) and 87.9 (10.2), p = 0.64; eosinophils % median (IQR) was 2.5 (1, 10) and 8 (2, 12.8), p = 0.07; lymphocytes % median (IQR) was 0 (0, 0.75) and 0 (0, 1) p = 0.13; macrophages % median (IQR) was 2.5 (0.75, 5.7) and 1 (0, 4.7) p = 0.13; and significant eosinophilia (eosinophils ≥3%) was 42 (49.4%) and 20 (71%), p=0.04, for TS-COPD and BMS-COPD, respectively. Conclusions. For similar severity of disease and clinical symptoms, significant eosinophilic inflammation was observed in stable BMS-COPD, while both groups had similar neutrophilic inflammation. Participant Consent. Obtained. Ethics Approval. The study was approved by the Institutional Ethics Committee of the Goa Medical College, Goa, India. Competing Interests. The authors declare no competing financial interests.

scholarly journals Comparison of biomarkers in serum and induced sputum of patients with occupational asthma and chronic obstructive pulmonary disease

2016 ◽  
Vol 58 (4) ◽  
pp. 333-339 ◽  
Author(s):  
Aneta Kleniewska ◽  
Jolanta Walusiak‐Skorupa ◽  
Wojciech Piotrowski ◽  
Ewa Nowakowska‐Świrta ◽  
Marta Wiszniewska
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Occupational Asthma ◽  
Induced Sputum ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease

scholarly journals The influence of various regimens of treatment on the level of proinflammatory cytokine TNF-alpha in induced sputum in case of an exacerbation of chronic obstructive pulmonary disease (copd) in persons, who suffered from pulmonary tuberculosis

2013 ◽  
Vol 17 (1 (65)) ◽  
pp. 38-40
Author(s):  
Ya. V. Ivanova
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Tuberculosis ◽  
Pulmonary Disease ◽  
Proinflammatory Cytokine ◽  
Combined Treatment ◽  
Induced Sputum ◽  
Tnf Alpha ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Tnf Α

The influence of various regimens of treatment of the regional (in induced sputum) level of proinflammatory cytokine TNF-α in patients with chronic obstructive pulmonary disease (COPD), who have suffered from pulmonary tuberculosis (PT), has been studied. An advantage of using a combined treatment of COPD exacerbation by means of β2agonist and an anticholinergic preparation (berodual), and also doxofillin (aerofillin) for the purpose of correcting regional (endobronchial) imbalance of cytokine homeostasis is proved.

scholarly journals Characteristics of induced sputum neutrophils and macrophages in patients with chronic obstructive pulmonary disease on a basic therapy

2011 ◽  
Vol 10 (6) ◽  
pp. 52-56
Author(s):  
S. V. Fedosenko ◽  
G. E. Chernogoryuk ◽  
N. A. Kirillova ◽  
A. Yu. Fisenko ◽  
Ye. P. Roslyakova
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Induced Sputum ◽  
Tiotropium Bromide ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Basic Therapy ◽  
Qualitative Characteristics

Aim of the research — to define the tiotropium bromide influence on bronchial neutrophiles and macrophages morphofunctional properties at stable of chronic obstructive pulmonary disease (COPD). The tiotropium using for 3 months has allowed to improve essentially qualitative characteristics of key effectors cells. The revealed changes were observed in all groups of patients irrespective of a previous mode of COPD treatment.

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