Backtracking-free design planning by automatic synthesis in metaframe

Urban Mongolia : an integrative culturally-sensitive sustainability-focused design + planning framework for ger districts

10.32469/10355/6697 ◽

2008 ◽

Author(s):

Brian R. Sinclair

Keyword(s):

Culturally Sensitive ◽

Planning Framework ◽

Design Planning

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REINTEGRATION OF THE CHORNOBYL NPP EXCLUSION ZONE ON THE BASIS OF THE DESIGN-PLANNING COMPLEX

Ukrainian geographical journal ◽

10.15407/ugz2020.04.011 ◽

2020 ◽

pp. 11-18

Author(s):

I.I. Ustinova ◽

◽

M.M. Dyomin ◽

G.V. Aylikova ◽

◽

...

Keyword(s):

Urban Planning ◽

City Planning ◽

Biosphere Reserve ◽

Brand Name ◽

Exclusion Zone ◽

Rational Development ◽

Production Complex ◽

Design Planning ◽

Renewable Energy Generation ◽

First Time

The aim of the publication is to determine the prerequisites of and to elaborate on the foundations of the Exclusion Zone reintegration in order to address the issue of rational development of urban-planning documentation complex regarding the legitimacy of said territory exploitation. It is established that for the implementation of the «Radioactive waste management strategy» the production complex «Vector» is being constructed on the Exclusion Zone territory; a powerful park of renewable energy generation is being created to implement the «Chornobyl - a Territory of Change» strategy; a Chornobyl Radiation-Ecological Biosphere Reserve was established to support and increase the barrier function of the zone; in order to promote the Safe Chornobyl brand-name, the tourist traffic is being increased and the conditions for the visitors are improving. In the absence of developed and approved city planning documentation, the listed above causes the problem of legitimacy and rationality of the exclusion zone territory use. The paper for the first time raises the question of the need to elaborate the concept of functional planning of the Chornobyl NPP exclusion zone territory and the development of the design-planning complex (urban planning documentation): from the territory.

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Automatic synthesis of optimal invariant assertions

ACM SIGPLAN Notices ◽

10.1145/872734.806926 ◽

1977 ◽

Vol 12 (8) ◽

pp. 1-12 ◽

Cited By ~ 19

Author(s):

Patrick Cousot ◽

Radhia Cousot

Keyword(s):

Automatic Synthesis

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Standardization of the [68Ga]Ga-PSMA-11 Radiolabeling Protocol in an Automatic Synthesis Module: Assessments for PET Imaging of Prostate Cancer

Pharmaceuticals ◽

10.3390/ph14050385 ◽

2021 ◽

Vol 14 (5) ◽

pp. 385

Author(s):

Leonardo L. Fuscaldi ◽

Danielle V. Sobral ◽

Ana Claudia R. Durante ◽

Fernanda F. Mendonça ◽

Ana Cláudia C. Miranda ◽

...

Keyword(s):

Prostate Cancer ◽

Pet Imaging ◽

Saline Solution ◽

Serum Proteins ◽

Single Photon ◽

Imaging Techniques ◽

Photon Emission ◽

Emission Computed Tomography ◽

Lncap Cells ◽

Automatic Synthesis

Prostate-specific membrane antigen (PSMA) is a glycoprotein present in the prostate, that is overexpressed in prostate cancer (PCa). Recently, PSMA-directed radiopharmaceuticals have been developed, allowing the pinpointing of tumors with the Positron Emission Tomography (PET) or Single Photon Emission Computed Tomography (SPECT) imaging techniques. The aim of the present work was to standardize and validate an automatic synthesis module-based radiolabeling protocol for [68Ga]Ga-PSMA-11, as well as to produce a radiopharmaceutical for PET imaging of PCa malignancies. [68Ga]Ga-PSMA-11 was evaluated to determine the radiochemical purity (RCP), stability in saline solution and serum, lipophilicity, affinity to serum proteins, binding and internalization to lymph node carcinoma of the prostate (LNCaP) cells, and ex vivo biodistribution in mice. The radiopharmaceutical was produced with an RCP of 99.06 ± 0.10%, which was assessed with reversed-phase high-performance liquid chromatography (RP-HPLC). The product was stable in saline solution for up to 4 h (RCP > 98%) and in serum for up to 1 h (RCP > 95%). The lipophilicity was determined as −3.80 ± 0.15, while the serum protein binding (SPB) was <17%. The percentages of binding to LNCaP cells were 4.07 ± 0.51% (30 min) and 4.56 ± 0.46% (60 min), while 19.22 ± 2.73% (30 min) and 16.85 ± 1.34% (60 min) of bound material was internalized. High accumulation of [68Ga]Ga-PSMA-11 was observed in the kidneys, spleen, and tumor, with a tumor-to-contralateral-muscle ratio of >8.5 and a tumor-to-blood ratio of >3.5. In conclusion, an automatic synthesis module-based radiolabeling protocol for [68Ga]Ga-PSMA-11 was standardized and the product was evaluated, thus verifying its characteristics for PET imaging of PCa tumors in a clinical environment.

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