Peptidergic sensory neurons in the control of vascular functions: Mechanisms and significance in the cutaneous and splanchnic vascular beds

Generation of monoclonal antibodies (MAbs) against tissue antigens has yielded several (VC1.1, HNK- 1, L2, 4F4 and anti-leu 7) which recognize the unique sugar epitope, glucuronyl 3-sulfate (Glc A3- SO4). In the central nervous system, these MAbs have demonstrated Glc A3-SO4 at the surface of neurons in the cerebral cortex, the cerebellum, the retina and other widespread regions of the brain.Here we describe the distribution of Glc A3-SO4 in the peripheral nervous system as determined by immunostaining with a MAb (VC 1.1) developed against antigen in the cat visual cortex. Outside the central nervous system, immunoreactivity was observed only in peripheral terminals of selected sensory nerves conducting transduction signals for touch, hearing, balance and taste. On the glassy membrane of the sinus hair in murine nasal skin, just deep to the ringwurt, VC 1.1 delineated an intensely stained, plaque-like area (Fig. 1). This previously unrecognized structure of the nasal vibrissae presumably serves as a tactile end organ and to our knowledge is not demonstrable by means other than its selective immunopositivity with VC1.1 and its appearance as a densely fibrillar area in H&E stained sections.

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An ultrastructural analysis of the sympathetic innervation of the rabbit ear artery and middle cerebral artery and their branches

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100125075 ◽

1992 ◽

Vol 50 (1) ◽

pp. 934-935

Author(s):

John T. Dodge ◽

John A. Bevan

Keyword(s):

Middle Cerebral Artery ◽

Cerebral Artery ◽

Sympathetic Innervation ◽

Electrical Field Stimulation ◽

Rabbit Ear Artery ◽

Electrical Field ◽

Functional Differences ◽

Ear Artery ◽

Rabbit Ear ◽

Vascular Beds

Unlike many peripheral vascular beds, the sympathetic nervous system exerts little control on cerebral blood flow. The contractile response of isolated rabbit middle cerebral artery (MCA) segments to electrical field stimulation of its intramural nerves is less than in a similar-sized artery from the ear. This study was undertaken to characterize and compare the perivascular neuromuscular relationships and innervation density of similar-sized arteries varying in diameter from these two different regional arterial beds to see if there were structural correlates for these functional differences.

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VRL-1-immunoreactive primary sensory neurons in the rat trigeminal nervous system

Neuroscience Research ◽

10.1016/s0168-0102(00)81119-0 ◽

2000 ◽

Vol 38 ◽

pp. S45 ◽

Cited By ~ 1

Author(s):

H Ichikawa

Keyword(s):

Nervous System ◽

Sensory Neurons ◽

Primary Sensory Neurons

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Adrenergic Stimulation of Regional Plasminogen Activator Release in Rabbits

Thrombosis and Haemostasis ◽

10.1055/s-0038-1646315 ◽

1992 ◽

Vol 68 (05) ◽

pp. 545-549 ◽

Cited By ~ 5

Author(s):

W L Chandler ◽

S C Loo ◽

D Mornin

Keyword(s):

Lower Extremity ◽

Plasminogen Activator ◽

Beta Blocker ◽

Time Course ◽

Vascular System ◽

Adrenergic Stimulation ◽

Epinephrine Administration ◽

Adrenergic Antagonist ◽

Vascular Beds ◽

Stimulation Of

SummaryThe purpose of this study was to determine whether different regions of the rabbit vascular system show variations in the rate of plasminogen activator (PA) secretion. To start, we evaluated the time course, dose response and adrenergic specificity of PA release. Infusion of 1 µg/kg of epinephrine stimulated a 116 ± 60% (SD) increase in PA activity that peaked 30 to 60 s after epinephrine administration. Infusion of 1 µg/kg of norepinephrine, isoproterenol and phenylephrine had no effect on PA activity. Pretreatment with phentolamine, an alpha adrenergic antagonist, blocked the release of PA by epinephrine while pretreatment with the beta blocker propranolol had no effect. This suggests that PA release in the rabbit was mediated by some form of alpha receptor.Significant arterio-venous differences in basal PA activity were found across the pulmonary and splanchnic vascular beds but not the lower extremity/pelvic bed. After stimulation with epinephrine, PA activity increased 46% across the splanchnic bed while no change was seen across the lower extremity/pelvic bed. We conclude that several vascular beds contribute to circulating PA activity in the rabbit, and that these beds secrete PA at different rates under both basal and stimulated conditions.

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