Chemical instabilities and applications of biological interest

2006 ◽  
pp. 119-122
Author(s):  
John Ross
Keyword(s):  
Biological Interest ◽  
Chemical Instabilities

Immunocytochemistry. A Review of Methodology for Electron Microscopic Applicaiton

1974 ◽  
Vol 32 ◽  
pp. 328-329
Author(s):  
Joseph E. Mazurkiewicz
Keyword(s):  
Electron Microscopy ◽  
Light Microscopy ◽  
Ultrastructural Level ◽  
Electron Microscopic ◽  
Biological Interest ◽  
Investigative Approach ◽  
Immunologic Activity ◽  
Dense Label

Immunocytochemistry is a powerful investigative approach in which one of the most exacting examples of specificity, that of the reaction of an antibody with its antigen, isused to localize tissue and cell specific molecules in situ. Following the introduction of fluorescent labeled antibodies in T950, a large number of molecules of biological interest had been studied with light microscopy, especially antigens involved in the pathogenesis of some diseases. However, with advances in electron microscopy, newer methods were needed which could reveal these reactions at the ultrastructural level. An electron dense label that could be coupled to an antibody without the loss of immunologic activity was desired.

Lipospheres: Emerging Carriers in the Delivery of Proteins and Peptides

1970 ◽  
Vol 1 (3) ◽  
pp. 207-214
Author(s):  
Manju Rawat ◽  
Swarnlata Saraf
Keyword(s):  
Drug Delivery ◽  
Protein Stability ◽  
Biodegradable Polymers ◽  
Clinical Utility ◽  
Physicochemical Characteristics ◽  
Peptide Delivery ◽  
Chemical Instabilities ◽  
Physical And Chemical ◽  
Proteins And Peptides

Currently, drug delivery technologies for protein and peptide delivery mainly rely on biodegradable polymers. However, protein stability during release from these systems can be critical due to physical and chemical instabilities. Lipospheres are solid microparticles composed of fat core stabilized by phospholipids layer represent an alternative carrier for the delivery of highly challenging, labile and unstable  substances. This review highlights various aspects of lipospheres like physicochemical characteristics and stability for better clinical utility with a wider spectrum of proteins and peptides.

PART I: NOVEL QUINOXALINE DERIVATIVES OF BIOLOGICAL INTEREST

2001 ◽  
Vol 24 (2) ◽  
pp. 135-144
Author(s):  
M. Badran ◽  
S. Botros ◽  
A. El-Gendy ◽  
N. Abdou ◽  
H. El-Assi ◽  
...  
Keyword(s):  
Biological Interest ◽  
Quinoxaline Derivatives ◽  
Derivatives Of

scholarly journals Stability of Metal Complexes with a Ligand of Biological Interest: Noradrenaline

1999 ◽  
Vol 23 (2) ◽  
pp. 90-91
Author(s):  
Christian Gérard ◽  
Hanane Chehhal ◽  
Michel Aplincourt
Keyword(s):  
Metal Complexes ◽  
Equilibrium Constants ◽  
Biological Interest ◽  
Potentiometric Measurements

Stoichiometry, equilibrium constants and spectra of iron(III) complexes with noradrenaline have been determined from spectrophotometric measurements; in addition equilibrium constants of complexes with MgII, CdII and PbII have been determined from potentiometric measurements.

Hydrothermal processing of interfacial BiCeO3/MWCNTs photocatalyst for rapid dye degradation and its biological interest

2021 ◽  
pp. 105774
Author(s):  
Jagadish Krishnegowda ◽  
Abhilash Mavinakere Ramesh ◽  
Akshatha Gangadhar ◽  
Srikantaswamy Shivanna
Keyword(s):  
Dye Degradation ◽  
Hydrothermal Processing ◽  
Biological Interest

scholarly journals Diverse Taxonomies for Diverse Chemistries: Enhanced Representation of Natural Product Metabolism in UniProtKB

Metabolites ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 48
Author(s):  
Marc Feuermann ◽  
Emmanuel Boutet ◽  
Anne Morgat ◽  
Kristian Axelsen ◽  
Parit Bansal ◽  
...  
Keyword(s):  
Natural Products ◽  
Natural Product ◽  
Semantic Web Technologies ◽  
Knowledge Resources ◽  
Web Technologies ◽  
Chemical Structures ◽  
Biological Interest ◽  
Catalyzed Reactions ◽  
Enzyme Catalyzed Reactions ◽  
Practical Demonstration

The UniProt Knowledgebase UniProtKB is a comprehensive, high-quality, and freely accessible resource of protein sequences and functional annotation that covers genomes and proteomes from tens of thousands of taxa, including a broad range of plants and microorganisms producing natural products of medical, nutritional, and agronomical interest. Here we describe work that enhances the utility of UniProtKB as a support for both the study of natural products and for their discovery. The foundation of this work is an improved representation of natural product metabolism in UniProtKB using Rhea, an expert-curated knowledgebase of biochemical reactions, that is built on the ChEBI (Chemical Entities of Biological Interest) ontology of small molecules. Knowledge of natural products and precursors is captured in ChEBI, enzyme-catalyzed reactions in Rhea, and enzymes in UniProtKB/Swiss-Prot, thereby linking chemical structure data directly to protein knowledge. We provide a practical demonstration of how users can search UniProtKB for protein knowledge relevant to natural products through interactive or programmatic queries using metabolite names and synonyms, chemical identifiers, chemical classes, and chemical structures and show how to federate UniProtKB with other data and knowledge resources and tools using semantic web technologies such as RDF and SPARQL. All UniProtKB data are freely available for download in a broad range of formats for users to further mine or exploit as an annotation source, to enrich other natural product datasets and databases.

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