scholarly journals The Role of the Complement Cascade in Ischemia/Reperfusion Injury: Implications for Neuroprotection

2001 ◽  
Vol 7 (6) ◽  
pp. 367-382 ◽  
Author(s):  
Anthony L. D’Ambrosio ◽  
David J. Pinsky ◽  
E. Sander Connolly
Author(s):  
W.G. Austen ◽  
L. Kobzik ◽  
M.C. Carroll ◽  
H.B. Hechtman ◽  
F.D. Moore

Activation of the complement cascade is central to many types of injury. Ischemia-reperfusion is an important example of such an event. Using intestinal ischemia-reperfusion as a model, we have further elucidated the importance and mechanism of this activation. Of novel importance is the evidence that natural antibody is a trigger for these events via recognition of self-antigen. In this article, we review the role of natural antibody and complement in intestinal ischemia-reperfusion injury. It is hoped that this study will ultimately lead to better understanding of these important modulators and their role in this type of injury.


2004 ◽  
Vol 171 (4S) ◽  
pp. 487-487
Author(s):  
Motoo Araki ◽  
Masayoshi Miura ◽  
Hiromi Kumon ◽  
John Belperio ◽  
Robert Strieter ◽  
...  

2010 ◽  
Vol 30 (2) ◽  
pp. 140-143
Author(s):  
De-yi ZHENG ◽  
Jian-ming WNAG ◽  
Yi-tao JIA ◽  
Jin-feng FU ◽  
Kai-yang LU ◽  
...  

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