scholarly journals Human Breast Carcinoma Cells Express Type II IL-4 Receptors and Are Sensitive to Antitumor Activity of a Chimeric IL-4-Pseudomonas Exotoxin Fusion Protein in vitro and in vivo

2000 ◽  
Vol 6 (3) ◽  
pp. 165-178 ◽  
Author(s):  
P. Leland ◽  
J. Taguchi ◽  
S. R. Husain ◽  
R. J. Kreitman ◽  
I. Pastan ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Antitumor Activity ◽  
Carcinoma Cells ◽  
Type Ii ◽  
Human Breast ◽  
Pseudomonas Exotoxin ◽  
Breast Carcinoma Cells ◽  
Human Breast Carcinoma Cells

Anti-invasive effect of gambogic acid in MDA-MB-231 human breast carcinoma cells

2008 ◽  
Vol 86 (5) ◽  
pp. 386-395 ◽  
Author(s):  
Qi Qi ◽  
Na Lu ◽  
Xiao-tang Wang ◽  
Hong-yan Gu ◽  
Yong Yang ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Carcinoma Cells ◽  
Human Breast Carcinoma ◽  
Matrix Metalloproteinase 2 ◽  
Migration And Invasion ◽  
Gambogic Acid ◽  
Human Breast ◽  
Breast Carcinoma Cells ◽  
Human Breast Carcinoma Cells

Gambogic acid (GA) has been known to have antitumor activity in vitro and in vivo. In the present study, we investigated the anti-invasive effects of GA in MDA-MB-231 human breast carcinoma cells. The results indicated that GA significantly inhibited the adhesion, migration, and invasion of the cells in vitro tested by the heterotypic adhesion assay, wound migration assay, and chamber invasion assay. Results of Western blotting and immunocytochemistry analysis showed that GA could suppress the expressions of matrix metalloproteinase 2 (MMP-2) and 9 (MMP-9) in MDA-MB-231 cells. Furthermore, gelatin zymography revealed that GA decreased the activities of MMP-2 and MMP-9. Additionally, GA exerted an inhibitory effect on the phosphorylation of ERK1/2 and JNK, while it had no effect on p38. Taken together, our results demonstrated the anti-invasive property of GA for the first time and indicated it could serve as a promising drug for the treatment of cancer metastasis.

scholarly journals Inhibition of cyclin D expression in human breast carcinoma cells by retinoids in vitro

Oncogene ◽  
1997 ◽  
Vol 15 (1) ◽  
pp. 107-115 ◽  
Author(s):  
Qun Zhou ◽  
Maryalice Stetler-Stevenson ◽  
Patricia S Steeg
Keyword(s):  
Breast Carcinoma ◽  
Carcinoma Cells ◽  
Human Breast Carcinoma ◽  
Cyclin D ◽  
Human Breast ◽  
Breast Carcinoma Cells ◽  
Human Breast Carcinoma Cells
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