scholarly journals Analysis of Families at Risk for Insulin-Dependent Diabetes Mellitus Reveals that HLA Antigens Influence Progression to Clinical Disease

1995 ◽  
Vol 1 (5) ◽  
pp. 576-582 ◽  
Author(s):  
Margo C. Honeyman ◽  
Leonard C. Harrison ◽  
Bruce Drummond ◽  
Peter G. Colman ◽  
Brian D. Tait
Keyword(s):  
Diabetes Mellitus ◽  
At Risk ◽  
Hla Antigens ◽  
Insulin Dependent Diabetes Mellitus ◽  
Clinical Disease ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Insulin Dependent

HLA Antigens and Immunoresponsiveness to Insulin in Insulin-Dependent Diabetes Mellitus

2008 ◽  
Vol 8 (1) ◽  
pp. 13-19 ◽  
Author(s):  
J. Bertrams ◽  
F.K. Jansen ◽  
D. Gruneklee ◽  
H.E. Reis ◽  
H. Drost ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Hla Antigens ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Insulin Dependent

Father-absent adolescents with insulin-dependent diabetes mellitus: A population at risk?

1988 ◽  
Vol 9 (2) ◽  
pp. 243-252 ◽  
Author(s):  
Cindy L. Hanson ◽  
Scott W. Henggeler ◽  
James R. Rodrigue ◽  
George A. Burghen ◽  
William D. Murphy
Keyword(s):  
Diabetes Mellitus ◽  
At Risk ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Population At Risk ◽  
Insulin Dependent

HLA antigens and age at diagnosis of insulin-dependent diabetes mellitus

1995 ◽  
Vol 42 (2) ◽  
pp. 116-122 ◽  
Author(s):  
Brian D. Tait ◽  
Leonard C. Harrison ◽  
Bruce P. Drummond ◽  
Vicky Stewart ◽  
Michael D. Varney ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Hla Antigens ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Age At Diagnosis ◽  
Dependent Diabetes Mellitus ◽  
Insulin Dependent

HLA antigens in four Pacific populations with non-insulin-dependent diabetes mellitus

1982 ◽  
Vol 9 (1) ◽  
pp. 69-84 ◽  
Author(s):  
S.W. Serjeantson ◽  
D.P. Ryan ◽  
P. Zimmet ◽  
R. Taylor ◽  
R. Cross ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Hla Antigens ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Insulin Dependent

Investigating class II HLA antigens' association with insulin-dependent diabetes mellitus in population of Vojvodina

2003 ◽  
Vol 56 (1-2) ◽  
pp. 26-31
Author(s):  
Svetlana Vojvodic
Keyword(s):  
Diabetes Mellitus ◽  
Relative Risk ◽  
Hla Antigens ◽  
Insulin Dependent Diabetes Mellitus ◽  
Class Ii ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Control Group ◽  
Significant Difference ◽  
Insulin Dependent

Introduction Class II HLA antigens were investigated in a group of 28 patients with insulin-dependent diabetes mellitus (IDDM) and 218 healthy unrelated persons (control group) from Vojvodina. Material and methods We used a modified two-colour immunofluorescence method (serologic technique) to determine the phenotype of DR and DQ locus HLA antigens. Phenotype frequencies of class II HLA antigens were determined in both investigated groups and were used for calculating relative risk (RR). If RR was higher than 1, we calculated the population attributable risk (EF), and if RR was lower than 1, we calculated the preventive fraction (PF). Investigation of statistically significant differences in frequencies of class II HLA antigens in patients and control group was performed by using ?2 test. Results Results of investigation showed that values of RR were higher than 1 for HLA DR4 (2,808), DR10 (1,116) and DQ3 (1,386), while we noticed a statistically significant difference in frequencies of HLA DR4 (?2 test: 4,805) in patients regarding control group. HLA DQ1 antigen has a preventive role in development of IDDM due to highest value of PF (0,314). Conclusion Results of our investigation confirm that there is an association of HLA DR4 with IDDM in population of Vojvodina. High values of relative risk of IDDM, noticed in persons with HLA DR4 antigen, point to the degree of risk of IDDM, which is a disease with great socioeconomic importance in Vojvodina.

HLA antigens in Type I (Insulin-Dependent) diabetes mellitus in North India

Metabolism ◽  
1981 ◽  
Vol 30 (10) ◽  
pp. 992-993 ◽  
Author(s):  
S. Srikanta ◽  
N.K. Mehra ◽  
M.C. Vaidya ◽  
A.N. Malaviya ◽  
M.M.S. Ahuja
Keyword(s):  
Diabetes Mellitus ◽  
Hla Antigens ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
North India ◽  
Dependent Diabetes Mellitus ◽  
Type I ◽  
Insulin Dependent
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