Quantal Nature of Generalization and Acquisition Responding by Rats in a Drug Discrimination Task

1987 ◽  
Vol 37 (2) ◽  
pp. 161-165 ◽  
Author(s):  
D. A. Mathis ◽  
M. W. Emmett-Oglesby ◽  
C. M. Harris ◽  
H. Lal
Keyword(s):  
Drug Discrimination ◽  
Discrimination Task

Discriminative stimulus, subject-rated and cardiovascular effects of cocaine alone and in combination with aripiprazole in humans

2010 ◽  
Vol 25 (11) ◽  
pp. 1469-1479 ◽  
Author(s):  
Joshua A Lile ◽  
William W Stoops ◽  
Paul EA Glaser ◽  
Lon R Hays ◽  
Craig R Rush
Keyword(s):  
Heart Rate ◽  
Drug Discrimination ◽  
Discriminative Stimulus ◽  
Discrimination Task ◽  
Partial Agonist ◽  
Cardiovascular Effects ◽  
Behavioral Effects ◽  
Acute Administration ◽  
Duration Of Treatment ◽  
Stimulant Use

Aripiprazole is a dopamine D2 receptor partial agonist undergoing evaluation as a pharmacotherapy for stimulant-use disorders. Acutely administered aripiprazole attenuates the discriminative stimulus and other behavioral effects of d-amphetamine in humans; however, whether aripiprazole attenuates the effects of more commonly abused stimulants is unknown. The aim of this experiment was to assess the discriminative stimulus, subject-rated and cardiovascular effects of oral cocaine alone and following acute administration of aripiprazole in humans. Eight cocaine-dependent subjects learned to discriminate 150 mg cocaine from placebo. After acquiring the discrimination, the effects of cocaine (0, 25, 50, 100 and 200 mg) administered alone and in combination with aripiprazole (15 mg) were determined. Significant effects of cocaine were observed for the drug discrimination task, stimulant-like subject-rated effects and heart rate. Limited effects of aripiprazole were revealed. However, for most measures, fewer doses of cocaine were significantly greater than placebo when combined with aripiprazole, suggesting a reduction in the discriminative stimulus, self-reported and cardiovascular effects of cocaine. These data are consistent with previous studies that have tested acutely administered aripiprazole in combination with d-amphetamine and suggest that the ability of aripiprazole to modify stimulant effects is a function of the duration of treatment (acute vs. chronic).

A three-choice haloperidol-saline-cocaine drug discrimination task in rats

1994 ◽  
Vol 49 (1) ◽  
pp. 223-227 ◽  
Author(s):  
David V. Gauvin ◽  
Kevin L. Goulden ◽  
Frank A. Holloway
Keyword(s):  
Drug Discrimination ◽  
Discrimination Task

Reversal of a drug versus drug discrimination task with different exteroceptive conditions

1991 ◽  
Vol 2 (4???5) ◽  
pp. 429???436 ◽  
Author(s):  
Henk J. Rijnders ◽  
Torbj??rn U.C. J??rbe ◽  
Jef L. Slangen
Keyword(s):  
Drug Discrimination ◽  
Discrimination Task

Chlorpyrifos Shares Stimulus Properties with Pentylenetetrazol as Evaluated by an Operant Drug Discrimination Task

2002 ◽  
Vol 23 (6) ◽  
pp. 795-803 ◽  
Author(s):  
M.C. Sánchez-Amate ◽  
E. Dávila ◽  
F. Cañadas ◽  
P. Flores ◽  
F. Sánchez-Santed
Keyword(s):  
Drug Discrimination ◽  
Discrimination Task ◽  
Stimulus Properties
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