Role of Discriminative Stimuli in Concurrent Performances: Duration of Changeover Delay

1978 ◽  
Vol 28 (2) ◽  
pp. 263-271 ◽  
Author(s):  
Gordon Bourland ◽  
James T. Miller
Keyword(s):  
Discriminative Stimuli ◽  
Changeover Delay

The Role of Discriminative Stimuli on Response Patterns in Resurgence

2016 ◽  
Vol 66 (3) ◽  
pp. 325-335 ◽  
Author(s):  
James E. King ◽  
Linda J. Hayes
Keyword(s):  
Response Patterns ◽  
Discriminative Stimuli

scholarly journals THE ROLE OF DISCRIMINATIVE STIMULI IN CONCURRENT PERFORMANCES

1981 ◽  
Vol 36 (2) ◽  
pp. 231-239 ◽  
Author(s):  
Gordon Bourland ◽  
James T. Miller
Keyword(s):  
Discriminative Stimuli

scholarly journals Discriminative stimuli are sufficient for incubation of cocaine craving

eLife ◽  
2019 ◽  
Vol 8 ◽  
Author(s):  
Rajtarun Madangopal ◽  
Brendan J Tunstall ◽  
Lauren E Komer ◽  
Sophia J Weber ◽  
Jennifer K Hoots ◽  
...  
Keyword(s):  
Relapse Prevention ◽  
Neural Mechanisms ◽  
Drug Addicts ◽  
Palatable Food ◽  
Discriminative Stimuli ◽  
Cocaine Craving ◽  
Seeking Behavior ◽  
Food Seeking ◽  
Over Time

In abstinent drug addicts, cues formerly associated with drug-taking experiences gain relapse-inducing potency (‘incubate’) over time. Animal models of incubation may help develop treatments to prevent relapse, but these models have ubiquitously focused on the role of conditioned stimuli (CSs) signaling drug delivery. Discriminative stimuli (DSs) are unique in that they exert stimulus-control over both drug taking and drug seeking behavior and are difficult to extinguish. For this reason, incubation of the excitatory effects of DSs that signal drug availability, not yet examined in preclinical studies, could be relevant to relapse prevention. We trained rats to self-administer cocaine (or palatable food) under DS control, then investigated DS-controlled incubation of craving, in the absence of drug-paired CSs. DS-controlled cocaine (but not palatable food) seeking incubated over 60 days of abstinence and persisted up to 300 days. Understanding the neural mechanisms of this DS-controlled incubation holds promise for drug relapse treatments.

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