Lowering of the coronary flow in isolated rat heart by equinatoxin II depends upon extracellular Ca2+ concentration

2000 ◽  
Vol 439 (7) ◽  
pp. R150-R151
Author(s):  
Gorazd Drevenšek ◽  
Matjaž Bunc ◽  
Metka V. Budihna ◽  
Dušan Šuput
Keyword(s):  
Rat Heart ◽  
Coronary Flow ◽  
Isolated Rat Heart ◽  
Equinatoxin Ii ◽  
Isolated Rat

Nicardipine dose dependently reduces the effect of equinatoxin II on coronary flow in isolated rat heart

2001 ◽  
Vol 442 (7) ◽  
pp. r198-r199
Author(s):  
Cvetka Grašič Kuhar ◽  
Matjaž Bunc ◽  
Gorazd Drevenšek ◽  
Metka V Budihna ◽  
Dušan šuput
Keyword(s):  
Rat Heart ◽  
Coronary Flow ◽  
Isolated Rat Heart ◽  
Equinatoxin Ii ◽  
Isolated Rat

Lowering of the coronary flow in isolated rat heart by equinatoxin II depends upon extracellular Ca2+ concentration

2000 ◽  
Vol 439 (S1) ◽  
pp. r150-r151 ◽  
Author(s):  
Gorazd Drevenšek ◽  
Matjaž Bunc ◽  
Metka V. Budihna ◽  
Dušan Šuput
Keyword(s):  
Rat Heart ◽  
Coronary Flow ◽  
Isolated Rat Heart ◽  
Equinatoxin Ii ◽  
Isolated Rat

Species-dependent hemodynamic effects of adenosine A3-receptor agonists IB-MECA and Cl-IB-MECA

1999 ◽  
Vol 276 (6) ◽  
pp. H2076-H2084 ◽  
Author(s):  
Robert D. Lasley ◽  
Prakash Narayan ◽  
M. Salik Jahania ◽  
Elizabeth L. Partin ◽  
Kathleen R. Kraft ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Rat Heart ◽  
Coronary Flow ◽  
Receptor Activation ◽  
Isolated Rat Heart ◽  
Pressure Effects ◽  
Hemodynamic Effects ◽  
Receptor Agonists ◽  
Coronary Dilation ◽  
Isolated Rat

The purpose of this study was to compare the hemodynamic effects of the adenosine A3-receptor agonists N 6-(3-iodobenzyl)-9-[5-(methylcarbamoyl)-β-d-ribofuranosyl]adenine (IB-MECA) and 2-chloro- N 6-(3-iodobenzyl)-9-[5-(methylcarbamoyl)-β-d-ribofuranosyl]adenine (Cl-IB-MECA) in isolated rat and rabbit hearts and in the intact, open-chest pig. Isolated hearts perfused with Krebs-Henseleit buffer at a constant pressure (70 mmHg) were treated with 50 nM of either IB-MECA or Cl-IB-MECA. Neither IB-MECA nor Cl-IB-MECA altered ventricular function or heart rate in the isolated rat and rabbit hearts, and neither agent altered coronary flow in the rabbit. However, 2 min of IB-MECA treatment in the isolated rat heart increased coronary flow by 25%, an effect that did not exhibit tachyphylaxis. The IB-MECA-induced coronary dilation was only partially attenuated by the adenosine A3-receptor antagonist MRS-1191 (50 nM). IB-MECA-induced coronary dilation was completely blocked by the adenosine A2a-receptor antagonist 7-(2-phenylethyl)-5-amino-2-(2-furyl)-pyrazolo-[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine (Sch-58261, 50 nM). Cl-IB-MECA (50 nM) did not increase coronary flow in the rat, but 100 nM did increase flow by 18%. In pentobarbital sodium-anesthetized pigs IB-MECA (5 μg/kg iv) decreased systemic blood pressure and increased pulmonary artery pressure, effects that did exhibit tachyphylaxis. These results illustrate that adenosine A3-receptor agonists produce species-dependent effects, which in the rat heart appear to be caused by adenosine A2a-receptor activation.

scholarly journals The perfusion of cisplatin and cisplatin structural analogues through the isolated rat heart: The effects on coronary flow and cardiodynamic parameters

2018 ◽  
Vol 37 (05) ◽  
pp. 515-525 ◽  
Author(s):  
I. M. Stojic ◽  
V. Lj. Jakovljevic ◽  
V. I. Zivkovic ◽  
I. M. Srejovic ◽  
T. R. Nikolic ◽  
...  
Keyword(s):  
Rat Heart ◽  
Coronary Flow ◽  
Isolated Rat Heart ◽  
Structural Analogues ◽  
Isolated Rat

Effect of Temperature and Coronary Flow on the Metabolic and Mechanical Function of the Isolated Rat Heart

Cardiology ◽  
1993 ◽  
Vol 82 (4) ◽  
pp. 238-248 ◽  
Author(s):  
Haywood Blum ◽  
Tamas Ivanics ◽  
Danning Zhang ◽  
Krzysztof Wroblewski ◽  
Mary D. Osbakken
Keyword(s):  
Rat Heart ◽  
Coronary Flow ◽  
Isolated Rat Heart ◽  
Effect Of Temperature ◽  
Mechanical Function ◽  
Isolated Rat

Mechanisms of antifibrillatory effect of acidic reperfusion: role of perfusate bicarbonate concentration

1993 ◽  
Vol 264 (3) ◽  
pp. H783-H790 ◽  
Author(s):  
C. Ibuki ◽  
D. J. Hearse ◽  
M. Avkiran
Keyword(s):  
Heart Rate ◽  
Ventricular Fibrillation ◽  
Rat Heart ◽  
Coronary Flow ◽  
Isolated Rat Heart ◽  
Acidic Ph ◽  
Bicarbonate Concentration ◽  
Left And Right ◽  
Isolated Rat

Transient (2 min) acidic (pH 6.6) reperfusion with low [HCO3-] solution suppresses reperfusion-induced ventricular fibrillation (VF) in the isolated rat heart. Using this preparation, we tested whether the effect was mediated by the high [H+] or the low [HCO3-] of perfusate. Left and right coronary beds were independently perfused with HCO3(-)-containing (25.0 mmol/l) solution at pH 7.4. Regional ischemia was then induced by stopping flow to the left coronary bed for 10 min. Hearts were subsequently assigned to four groups (n = 12 hearts/group), and the left coronary bed was reperfused with either HCO3(-)-containing (25.0 or 4.0 mmol/l) or HCO3(-)-free (5.0 mmol/l HEPES) solution, at pH 7.4 throughout (control reperfusion) or at pH 6.6 for the first 2 min and at pH 7.4 from 2 to 5 min (acidic reperfusion). Regardless of the buffer, controls exhibited a high (92 and 100%) incidence of VF; this was reduced to 42% in both of the acidic reperfusion groups (P < 0.05). There were no intergroup differences in heart rate, coronary flow, or size of ischemic zone. Thus high [H+], rather than low [HCO3-], appears to mediate the antifibrillatory effect of transient acidic reperfusion.

Blood-perfused working isolated rat heart

1976 ◽  
Vol 41 (4) ◽  
pp. 603-607 ◽  
Author(s):  
M. A. Duvelleroy ◽  
M. Duruble ◽  
J. L. Martin ◽  
B. Teisseire ◽  
J. Droulez ◽  
...  
Keyword(s):  
Rat Heart ◽  
Coronary Flow ◽  
Myocardial Oxygen Consumption ◽  
Isolated Rat Heart ◽  
Red Cells ◽  
Red Cell ◽  
External Work ◽  
Bicarbonate Buffer ◽  
Isolated Rat ◽  
Human Red Cells

We describe a method for perfusion of a working isolated rat heart with washed erythrocytes suspended in a Krebs-Henseleit bicarbonate buffer containing bovine albumin (fraction V). With washed pig red cells, as hematocritwas varied between 0 and 40%, coronary flow (CF), aortic flow (AF), external work (W), and myocardial oxygen consumption (MVO2) were measured. Hemodynamic data at a hematocrit of 30% (CF = 5.4 +/- 0.7 ml/min per g, AF = 75 +/- 8 ml/min per g) were identical with those reported for the intact animal.Coronary sinus PO2 was highest with a red cell-free perfusate suggesting that coronary flow is partially shunted. Human red cells obtained from bankedblood, were tried also with success. With careful filtration, the preparation is stable for 2 h and well suited for study of the dynamics of myocardial oxygen delivery.

Increase on the coronary flow induced by dioclein in isolated rat heart

Life Sciences ◽  
2002 ◽  
Vol 70 (10) ◽  
pp. 1121-1128 ◽  
Author(s):  
Alvair P. Almeida ◽  
Steyner F. Côrtes ◽  
Anderson J. Ferreira ◽  
Virgı́nia S. Lemos
Keyword(s):  
Rat Heart ◽  
Coronary Flow ◽  
Isolated Rat Heart ◽  
Isolated Rat
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