Thyroid function evaluation by different commercially available free thyroid hormone measurement kits in term pregnant women and their newborns

1991 ◽  
Vol 14 (1) ◽  
pp. 1-9 ◽  
Author(s):  
E. Roti ◽  
E. Gardini ◽  
R. Minelli ◽  
L. Bianconi ◽  
M. Flisi
Keyword(s):  
Thyroid Hormone ◽  
Pregnant Women ◽  
Thyroid Function ◽  
Function Evaluation ◽  
Free Thyroid Hormone

scholarly journals Low serum selenium in pregnancy is associated with reduced T3 and increased risk of GDM

2021 ◽  
Vol 248 (1) ◽  
pp. 45-57
Author(s):  
Pierre Hofstee ◽  
Janelle James-McAlpine ◽  
Daniel R McKeating ◽  
Jessica J Vanderlelie ◽  
James S M Cuffe ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Pregnant Women ◽  
Thyroid Function ◽  
Tertiary Care ◽  
Endocrine Disorders ◽  
Serum Selenium ◽  
Selenium Status ◽  
Increased Risk ◽  
The Relationship ◽  
Low Serum

Thyroid disorders are the most common endocrine disorders affecting women commencing pregnancy. Thyroid hormone metabolism is strongly influenced by selenium status; however, the relationship between serum selenium concentrations and thyroid hormones in euthyroid pregnant women is unknown. This study investigated the relationship between maternal selenium and thyroid hormone status during pregnancy by utilizing data from a retrospective, cross-sectional study (Maternal Outcomes and Nutrition Tool or MONT study) with cohorts from two tertiary care hospitals in South East Queensland, Australia. Pregnant women (n = 206) were recruited at 26–30 weeks gestation and serum selenium concentrations were assessed using inductively coupled plasma mass spectrometry. Thyroid function parameters were measured in serum samples from women with the lowest serum selenium concentrations (51.2 ± 1.2 µg/L), women with mean concentrations representative of the entire cohort (78.8 ± 0.4 µg/L) and women with optimal serum selenium concentrations (106.9 ± 2.3 µg/L). Women with low serum selenium concentrations demonstrated reduced fT3 levels (P < 0.05) and increased TPOAb (P < 0.01). Serum selenium was positively correlated with fT3 (P < 0.05) and negatively correlated with TPOAb (P < 0.001). Serum fT4 and thyroid-stimulating hormone (TSH) were not different between all groups, though the fT4/TSH ratio was increased in the low selenium cohort (P < 0.05). Incidence of pregnancy disorders, most notably gestational diabetes mellitus, was increased within the low serum selenium cohort (P < 0.01). These results suggest selenium status in pregnant women of South East Queensland may not be adequate, with possible implications for atypical thyroid function and undesirable pregnancy outcomes.

Free thyroid hormone index, thyroid hormone/thyroxin-binding globulin ratio, triiodothyronine uptake, and thyroxin-binding globulin compared for diagnostic value regarding thyroid function.

1983 ◽  
Vol 29 (1) ◽  
pp. 74-79 ◽  
Author(s):  
T J Wilke
Keyword(s):  
Thyroid Hormone ◽  
Thyroid Function ◽  
Diagnostic Value ◽  
Clinical Findings ◽  
Thyroid Function Tests ◽  
Free Thyroid Hormone ◽  
Age Related ◽  
Age Dependent ◽  
Uptake Test ◽  
The Relationship

Abstract The thyroid hormone/thyroxin-binding globulin (TBG) ratio and the free thyroid hormone index (FTI) were compared in 372 subjects classified according to age, sex, and biochemical and clinical findings. Age-related variations in thyroid function tests were investigated, as was the relationship between triiodothyronine uptake and TBG. Men, but not women, showed significant age-dependent changes in concentrations of thyroid hormones. FTI was as good as the thyroid hormone/TBG ratio in hyperthyroidism and was a better index of thyroid status in pregnancy, TBG deficiency, and hypothyroidism. In addition, the triiodothyronine uptake correlated extremely well with TBG (r = -0.95, p less than 0.001) and was very efficient in detecting decreased and significantly increased concentrations of TBG. I conclude that FTI is a better discriminator of functional status of the thyroid over a wider range of TBG values than is the thyroid hormone/TBG ratio. Further, the triiodothyronine uptake test produced diagnostic information equivalent to that of TBG estimation and thus should not be replaced in routine use.

scholarly journals Iodine and Pregnancy

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Christina Yarrington ◽  
Elizabeth N. Pearce
Keyword(s):  
Thyroid Hormone ◽  
Pregnant Women ◽  
Thyroid Function ◽  
Environmental Contaminants ◽  
Iodine Status ◽  
Nutritional Recommendations ◽  
Iodine Metabolism ◽  
The Impact ◽  
In Pregnancy

Iodine is a necessary element for the production of thyroid hormone. We will review the impact of dietary iodine status on thyroid function in pregnancy. We will discuss iodine metabolism, homeostasis, and nutritional recommendations for pregnancy. We will also discuss the possible effects of environmental contaminants on iodine utilization in pregnant women.

Comparison of calculated and measured free thyroid hormones in serum in health and in abnormal states.

1982 ◽  
Vol 28 (6) ◽  
pp. 1325-1329 ◽  
Author(s):  
G Fresco ◽  
G Curti ◽  
A Biggi ◽  
B Fontana
Keyword(s):  
Thyroid Hormone ◽  
Thyroid Hormones ◽  
Pregnant Women ◽  
Healthy Subjects ◽  
Normal Subjects ◽  
Mass Action ◽  
Law Of Mass Action ◽  
Free Triiodothyronine ◽  
Free Thyroid Hormones ◽  
Free Thyroid Hormone

Abstract To evaluate a theoretical model for calculating free thyroid hormones, based on the law of mass action, we compared values for both calculated and measured free thyroxin and free triiodothyronine in a group of normal subjects. To determine whether the concentrations of circulating free hormones were also predictable from equilibrium considerations in abnormal states, we compared calculated and measured free thyroid hormone values in an additional population including pregnant women and hyperthyroid, hypothyroid, and "sick euthyroid" patients. Predictions based on the model were accurate in all these states except pregnancy, where there was some discrepancy between calculated and measured values for both hormones. In pregnant women with large abnormalities in thyroid-hormone-binding proteins, euthyroidism was accompanied by significantly lower free hormone concentrations, leading us to conclude that, in pregnancy, equilibrium may be reached at concentrations lower than those in other healthy subjects. Values for calculated and measured free thyroid hormones in "sick euthyroids" showed no discrepancy; however, we cannot exclude the possibility that non-dialyzable compounds are present that interfere with the hormone-protein binding.

scholarly journals False hyperthyroidism caused by interference in immunoassays

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Clara Jiménez García ◽  
Piedad Ortega Fernández ◽  
María Eugenia Torregrosa Quesada ◽  
Victoria González Bueno ◽  
María Teresa Botella Belda ◽  
...  
Keyword(s):  
Decision Making ◽  
Thyroid Hormone ◽  
Thyroid Function ◽  
Thyroid Disease ◽  
Clinical Decision Making ◽  
Clinical Symptoms ◽  
Clinical Decision ◽  
Case Presentation ◽  
Free Thyroid Hormone ◽  
Different Types

AbstractObjectivesImmunoassays used to assess thyroid function are vulnerable to different types of interference that may affect clinical decision-making.Case presentationWe report the case of a 37-year-old woman who developed iatrogenic hypothyroidism after having received radioiode therapy who visited our hospital for her annual checkup. The patient was asymptomatic, without signs suggestive of thyroid disease. However, laboratory analysis proved otherwise: thyrotropin (TSH) 7.75 mU/L, thyroxine (FT4) >7.7 ng/dL.ConclusionsThe inconsistency between her clinical symptoms and the biochemistry data raised the possibility of a methodological interference. A thorough evaluation of the main causes of interference was conducted in the laboratory to exclude the presence of interference in TSH and FT4. Finally, different interfering agents were identified, which affected free thyroid hormone and TSH determination.

scholarly journals Thyroid hormone profile in apparently healthy pregnant women attending in a tertiary care hospital of Bangladesh

2016 ◽  
Vol 8 (2) ◽  
pp. 91
Author(s):  
Murshed Ahamed Khan ◽  
M.A. Hasanat ◽  
Md. Jahangir Alam ◽  
Md. Anwar Hossain ◽  
Ahmed Abu Saleh ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Pregnant Women ◽  
Thyroid Function ◽  
Gestational Age ◽  
Tertiary Care ◽  
American Thyroid Association ◽  
Reference Ranges ◽  
Care Hospital ◽  
Cross Sectional ◽  
Hormone Profile

<p><strong>Background:</strong> Thyroid dysfunction is not uncommon in pregnancy. It should be evaluated for better outcome of pregnancy.</p><p><strong>Objective:</strong> To observe the thyroid hormone profile in apparently euthyroid pregnant women of any trimester. Methods: This cross-sectional study investigated 350 pregnant women irrespective of gestational age [(age 24±4, m±SDyr; 1st trimester = 101, 2nd trimester=111, 3rd trimester=138) for thyroid stimulating hormone (TSH) and for free thyroxine (FT4)] to assess their thyroid function during pregnancy following the criteria of American Thyroid Association (ATA).</p><p><strong>Results:</strong> Most of the mothers were housewifes (93.1 %, 326/350) of whom 46.6% were primigravida. About 63% mother had associated goiter, 58% (204/350) were euthyroid and 41 % (142/350) were subclinical hypothyroid (SCH). Frequency of goiter (63% vs. 62%, euthyroid vs. dysfunction) was not significantly different between dysfunction and normal groups. FT4 significantly correlated with gestational age (r= - 0.131, p=0.014) and TSH level (r= - 0.612, p&lt; 0.001).</p><p><strong>Conclusion:</strong> It is concluded that many of the apparently euthyroid pregnant mother have dysfunction as defined by ATA reference ranges for TSH and FT4. Simple screening for thyroid function may have greater implication for better pregnancy outcome.</p>

scholarly journals Serum Free Thyroxine and Free Triiodothyronine Concentrations in Healthy Fullterm, Preterm and Sick Preterm Neonates

1987 ◽  
Vol 24 (5) ◽  
pp. 461-465 ◽  
Author(s):  
Rhys John ◽  
Fiona J Bamforth
Keyword(s):  
Thyroid Hormone ◽  
Thyroid Function ◽  
Neonatal Period ◽  
Free Thyroxine ◽  
Preterm Neonates ◽  
Reference Ranges ◽  
Free Triiodothyronine ◽  
Widespread Application ◽  
Early Neonatal Period ◽  
Free Thyroid Hormone

There are few data available on free thyroid hormone concentrations in the early neonatal period. With the widespread application of screening procedures for detecting congenital hypothyroidism there is a need for reference ranges in neonates. In this study we have evaluated thyroid function in healthy fullterm and preterm neonates, and sick neonates all within one to 10 days postnatal age. Our data indicates that free thyroxine but not free triiodothyronine is higher in fullterm neonates than the adult reference range and that both free thyroid hormone concentrations are reduced in healthy and sick preterm neonates as compared to fullterm neonates. Assessment of thyroid function in the early neonatal period needs to take into account these changes particularly in preterm and sick preterm neonates.

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