Raised plasma levels of atrial natriuretic peptides in Addison’s disease

1989 ◽  
Vol 12 (3) ◽  
pp. 205-207 ◽  
Author(s):  
F. P. Cappuccio ◽  
N. D. Markandu ◽  
M. G. Buckley ◽  
A. L. Sugden ◽  
G. A. Sagnella ◽  
...  
Keyword(s):  
Natriuretic Peptides ◽  
Plasma Levels ◽  
Addison’S Disease ◽  
Addison's Disease ◽  
Atrial Natriuretic Peptides ◽  
Atrial Natriuretic

Changes in the plasma levels of atrial natriuretic peptides during mineralocorticoid escape in man

1987 ◽  
Vol 72 (5) ◽  
pp. 531-539 ◽  
Author(s):  
Francesco P. Cappuccio ◽  
Nirmala D. Markandu ◽  
Martin G. Buckley ◽  
Giuseppe A. Sagnella ◽  
Angela C. Shore ◽  
...  
Keyword(s):  
Atrial Natriuretic Peptide ◽  
Healthy Volunteers ◽  
Natriuretic Peptide ◽  
Natriuretic Peptides ◽  
Plasma Levels ◽  
Sodium Intake ◽  
Atrial Natriuretic Peptides ◽  
Atrial Natriuretic

1. Plasma levels of atrial natriuretic peptide (ANP) were measured by radioimmunoassay in eight normal healthy volunteers before and during mineralocorticoid escape. 2. Mean plasma ANP on a fixed sodium intake before fludrocortisone was 6.5± sem 1.1 pg/ml. Within 24 h of fludrocortisone administration there was a significant increase in plasma ANP which continued to increase daily reaching a plateau by day 4 (14.9 ± 2.4 pg/ml) to day 7 (15.1 ± 2.6 pg/ml). 3. The rise in plasma ANP was closely related to the amount of sodium retained during the fludrocortisone treatment and the sodium ‘escape’ occurred by days 4 to 7. 4. These results support the concept that ANP could play an important hormonal role in overcoming the sodium-retaining effects of mineralocorticoids in man.

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