A marked molecular heterogeneity of growth hormone (GH) detected in the plasma but not pituitary of a patient with acromegaly: Comparison with other acromegalics and an implication for discrepant plasma levels of GH and insulin-like growth factor I

1992 ◽  
Vol 15 (5) ◽  
pp. 381-386
Author(s):  
H. Watanobe ◽  
M. Ishii ◽  
T. Kudo ◽  
A. Nagata ◽  
K. Takebe
Keyword(s):  
Growth Hormone ◽  
Growth Factor ◽  
Plasma Levels ◽  
Molecular Heterogeneity ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Growth Factor I

Effects of two oral contraceptives on plasma levels of insulin-like growth factor I (IGF-I) and growth hormone (hGH)

Contraception ◽  
2000 ◽  
Vol 62 (5) ◽  
pp. 259-269 ◽  
Author(s):  
A Balogh ◽  
E Kauf ◽  
R Vollanth ◽  
G Gräser ◽  
G Klinger ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Factor ◽  
Oral Contraceptives ◽  
Plasma Levels ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Igf I ◽  
Growth Factor I

Progestin treatment in the dog I. Effects on growth hormone, insulin-like growth factor I and glucose homeostasis

1994 ◽  
Vol 131 (4) ◽  
pp. 413-421 ◽  
Author(s):  
PJ Selman ◽  
JA Mol ◽  
GR Rutteman ◽  
A Rijnberk
Keyword(s):  
Growth Hormone ◽  
Growth Factor ◽  
Glucose Homeostasis ◽  
Plasma Levels ◽  
Insulin Like Growth Factor ◽  
Treatment Groups ◽  
Factor I ◽  
Igf I ◽  
Progestin Treatment ◽  
Growth Factor I

Selman PJ, Mol JA, Rutteman GR, Rijnberk A. Progestin treatment in the dog. I. Effects on growth hormone, insulin-like growth factor I and glucose homeostasis. Eur J Endocrinol 1994;131:413–21. ISSN 0804–4643 The effects of two synthetic progestins, medroxyprogesterone acetate (MPA) and proligestone (PROL), on the release of growth hormone (GH) and glucose metabolism were studied in two groups of eight ovariohysterectomized dogs. Eight injections of long-acting progestins were administered at 3-week intervals. Recovery was studied in four dogs of each treatment group in the 6 months following cessation of progestin administration. Treatment with both MPA and PROL resulted in similar increases in plasma levels of GH and insulin-like growth factor I (IGF-I). The GH responses to both clonidine and growth hormone-releasing hormone became impaired. In neither treatment group did the elevated plasma GH levels decrease after administration of the synthetic somatostatin analogue SMS 201-995. The size and shape of the pituitary gland were not changed by progestin treatment. After cessation of progestin administration, basal plasma levels of GH and IGF-I did not return to pretreatment values. The GH response to growth hormone-releasing hormone remained impaired for at least 6 months after the last progestin administration. In both treatment groups, glucose homeostasis was sustained initially by increased insulin production. Prolonged treatment with MPA and PROL resulted in glucose intolerance. No amelioration was observed during the recovery period in either group. A small number of dogs developed diabetes mellitus. In more than 50% of the dogs in both treatment groups small mammary tumours developed. The recently discovered local production of GH probably played a role in mammary tumorigenesis. It is concluded that treatment with MPA and PROL results in similar increases in plasma levels of GH and IGF-I and leads to a similar degree of insulin resistance. The elevated GH levels can be neither stimulated nor inhibited, which is a feature compatible with autonomous secretion. These results are consistent with the recent finding of a progestin-induced ectopic production of GH in the mammary gland of the dog. JA Mol, Department of Clinical Sciences of Companion Animals, Utrecht University, PO Box 80. 154, 3508 TD Utrecht, The Netherlands

Relationship between Cognitive Function, Growth Hormone and Insulin-Like Growth Factor I Plasma Levels in Aged Subjects

1998 ◽  
Vol 38 (2) ◽  
pp. 73-79 ◽  
Author(s):  
Alessandro Rollero ◽  
Giovanni Murialdo ◽  
Stefano Fonzi ◽  
Simona Garrone ◽  
Maria V. Gianelli ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Cognitive Function ◽  
Growth Factor ◽  
Plasma Levels ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Growth Factor I ◽  
Aged Subjects
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