Clinical significance of elevated labeled TSH binding (LTB) activity in sera of patients with Graves’ disease and other thyroid disorders

1987 ◽  
Vol 10 (5) ◽  
pp. 459-464 ◽  
Author(s):  
Takashi Akamizu ◽  
T. Mori ◽  
H. Ishii ◽  
T. Yokota ◽  
H. Nakamura ◽  
...  
Keyword(s):  
Clinical Significance ◽  
Graves Disease ◽  
Thyroid Disorders

Clinical significance of anti-TSH antibody in sera from patients with Graves’ disease and other thyroid disorders

1989 ◽  
Vol 12 (7) ◽  
pp. 483-488 ◽  
Author(s):  
T. Akamizu ◽  
Toru Mori ◽  
H. Imura ◽  
J. Noh ◽  
N. Hamada ◽  
...  
Keyword(s):  
Clinical Significance ◽  
Graves Disease ◽  
Thyroid Disorders

Coexistence of diabetic ketoacidosis and thyrotoxicosis: a jeopardy of two endocrine emergencies

2021 ◽  
Vol 14 (6) ◽  
pp. e243534
Author(s):  
Soban Ahmad ◽  
Amman Yousaf ◽  
Shoaib Muhammad ◽  
Fariha Ghaffar
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Ketoacidosis ◽  
Clinical Presentation ◽  
Early Recognition ◽  
Favourable Outcome ◽  
Adverse Outcomes ◽  
Thyroid Storm ◽  
Graves Disease ◽  
Thyroid Disorders ◽  
History Of

Simultaneous occurrences of diabetic ketoacidosis (DKA) and thyroid storm have long been known, but only a few cases have been reported to date. Both these endocrine emergencies demand timely diagnosis and management to prevent adverse outcomes. Due to the similarities in their clinical presentation, DKA can mask the diagnosis of thyroid storm and vice versa. This case report describes a patient with Graves’ disease who presented to the emergency department with nausea, vomiting and abdominal pain. He was found to have severe DKA without an explicit history of diabetes mellitus. Further evaluation revealed that the patient also had a concomitant thyroid storm that was the likely cause of his DKA. Early recognition and appropriate management of both conditions resulted in a favourable outcome. This paper emphasises that a simultaneous thyroid storm diagnosis should be considered in patients with DKA, especially those with a known history of thyroid disorders.

THE CLINICAL SIGNIFICANCE OF ELECTRICAL IMPEDANCE DETERMINATION IN THYROID DISORDERS*

Endocrinology ◽  
1936 ◽  
Vol 20 (1) ◽  
pp. 72-80 ◽  
Author(s):  
J. W. HORTON ◽  
A. C. VANRAVENSWAAY ◽  
SAUL HERTZ ◽  
G. W. THORN
Keyword(s):  
Clinical Significance ◽  
Electrical Impedance ◽  
Thyroid Disorders

The Prevalence and Clinical Significance of Blocking Thyrotropin Receptor Antibodies in Untreated Hyperthyroid Graves' Disease

Thyroid ◽  
2000 ◽  
Vol 10 (7) ◽  
pp. 579-586 ◽  
Author(s):  
Won Bae Kim ◽  
Hyun Kyung Chung ◽  
Young Joo Park ◽  
Do Joon Park ◽  
Kazuo Tahara ◽  
...  
Keyword(s):  
Clinical Significance ◽  
Graves Disease ◽  
Thyrotropin Receptor ◽  
Thyrotropin Receptor Antibodies ◽  
Receptor Antibodies

MR imaging in thyroid disorders: correlation of signal intensity with Graves disease activity.

Radiology ◽  
1987 ◽  
Vol 164 (2) ◽  
pp. 491-494 ◽  
Author(s):  
N D Charkes ◽  
A H Maurer ◽  
J A Siegel ◽  
P D Radecki ◽  
L S Malmud
Keyword(s):  
Mr Imaging ◽  
Disease Activity ◽  
Signal Intensity ◽  
Graves Disease ◽  
Thyroid Disorders

scholarly journals Identification of thyroid hormone residues on serum thyroglobulin: a clue to the source of circulating thyroglobulin in thyroid diseases

1999 ◽  
Vol 140 (5) ◽  
pp. 457-467 ◽  
Author(s):  
L Druetta ◽  
H Bornet ◽  
G Sassolas ◽  
B Rousset
Keyword(s):  
Monoclonal Antibody ◽  
Differentiated Thyroid Cancer ◽  
Follicular Carcinoma ◽  
Iodine Content ◽  
Graves Disease ◽  
Thyroid Disorders ◽  
Step Method ◽  
Serum Thyroglobulin ◽  
Normal Individuals ◽  
First Time

Thyroglobulin (Tg) present in the serum of normal individuals and patients with thyroid disorders could be partly newly synthesized non-iodinated Tg and partly Tg containing iodine and hormone residues originating from the lumen of thyroid follicles. With the aim of examining the contribution of the latter source of Tg to the elevation of serum Tg concentration in thyroid pathophysiological situations, we devised a procedure to identify thyroxine (T4) and tri-iodothyronine (T3) residues on Tg from unfractionated serum. A two-step method, basedon (i)adsorption of Tg on an immobilized anti-human Tg (hTg) monoclonal antibody (mAb) and (ii)recognition of hormone residues on adsorbed Tg by binding of radioiodinated anti-T4 mAb and anti-T3 mAb, was used to analyze serum Tg from patients with either Graves' disease (GD), subacute thyroiditis (ST) or metastatic differentiated thyroid cancer (DTC). Purified hTg preparations with different iodine and hormone contents were used as reference. Adsorption of purified Tg and serum Tg on immobilized anti-hTg mAb ranged between 85 and 90% over a wide concentration range. Labeled anti-T4 and anti-T3 mAbs bound to adsorbed purified Tg in amounts related to its iodine content. Tg adsorbed from six out of six sera from ST exhibited anti-T4 and anti-T3 mAb binding activities. In contrast, significant mAb binding was only observed in one out of eight sera from untreated GD patients and in 1 out of 13 sera from patients with DTC. The patient with DTC, whose serum Tg contained T4 and T3, represented a case of hyperthyroidism caused by a metastatic follicular carcinoma. In conclusion, we have identified, for the first time, T4 and T3 residues on circulating Tg. The presence of Tg with hormone residues in serum is occasional in GD and DTC but is a common and probably distinctive feature of ST.

Serum myoglobin in thyroid disease

1980 ◽  
Vol 94 (2) ◽  
pp. 184-187 ◽  
Author(s):  
F. A. Karlsson ◽  
P. A. Dahlberg ◽  
P. Venge ◽  
L. E. Roxin
Keyword(s):  
Thyroid Disease ◽  
Healthy Subjects ◽  
Reference Range ◽  
Subacute Thyroiditis ◽  
Graves Disease ◽  
Thyroid Disorders ◽  
Muscular Weakness ◽  
De Quervain ◽  
Serum Myoglobin

Abstract. Serum myoglobin levels were measured longitudinally in patients undergoing therapy because of various thyroid disorders. Elevated myoglobin values - 72.6 (58.7–89.7) μg/l (mean ± sem) were found in a group of hypothyroid subjects. The degree of myoglobin increase seemed related to the severity of hypothyroidism. When rendered euthyroid the myoglobin levels of these patients were normalized − 41.0 (37.3–45.1) μg/l. In patients with hyperthyroidism, due to Graves' disease or subacute thyroiditis (de Quervain), only minor changes of myoglobin values within the reference range of healthy subjects, were measured. This suggests that mechanisms not affecting myoglobin release are responsible for the muscular weakness of thyrotoxic patients.

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