Thyroid hormones homeostasis in rats refed after short-term and prolonged fasting

1996 ◽  
Vol 19 (5) ◽  
pp. 304-311 ◽  
Author(s):  
Z. Kmiec ◽  
G. Kotlarz ◽  
B. Smiechowska ◽  
A. Mysliwski
1990 ◽  
Vol 259 (3) ◽  
pp. E305
Author(s):  
V Piolino ◽  
K J Acheson ◽  
M J Müller ◽  
N Jeanprêtre ◽  
A G Burger ◽  
...  

The interactions between thyroid hormones, epinephrine, and insulin in the regulation of energy expenditure were investigated in a group of healthy young men before and after thyroxine (T4) treatment (300 micrograms/day for 14 days) at basal plasma insulin concentrations and during hypoinsulinemia with and without epinephrine infusion (0.05 micrograms.kg fat-free mass-1.min-1). T4 treatment induced moderate hyperthyroidism and increased resting energy expenditure (RMR). The effect was more pronounced during short-term hypoinsulinemia, but hypoinsulinemia by itself did not influence RMR. Epinephrine infusion caused a significant increase in energy expenditure. The effect was most pronounced at hypoinsulinemia and with T4 treatment. Hypoinsulinemia and T4 treatment were not additive in their effects. We conclude that basal insulin concentrations mask some of the thermogenic effects of thyroid hormones and epinephrine. Thus insulin antagonism may suppress some of the thermogenic actions of thyroid hormones and epinephrine.


2011 ◽  
Vol 43 (Suppl 1) ◽  
pp. 668-669
Author(s):  
David W. DeGroot ◽  
Matthew R. Ely ◽  
J Philip Karl ◽  
Andrew J. Young

Endocrinology ◽  
2002 ◽  
Vol 143 (5) ◽  
pp. 1660-1668 ◽  
Author(s):  
Sandra Incerpi ◽  
Paolo De Vito ◽  
Paolo Luly ◽  
Silvana Spagnuolo ◽  
Silvia Leoni

2020 ◽  
Vol 71 ◽  
pp. 106389 ◽  
Author(s):  
J.M. Prieto ◽  
P.C. Carney ◽  
M.L. Miller ◽  
M. Rishniw ◽  
J.F. Randolph ◽  
...  

PLoS ONE ◽  
2018 ◽  
Vol 13 (10) ◽  
pp. e0205293 ◽  
Author(s):  
Paolo Marzullo ◽  
Alessandro Minocci ◽  
Chiara Mele ◽  
Rezene Fessehatsion ◽  
Mariantonella Tagliaferri ◽  
...  

2003 ◽  
Vol 284 (5) ◽  
pp. R1277-R1286 ◽  
Author(s):  
Buel D. Rodgers ◽  
Gregory M. Weber ◽  
Kevin M. Kelley ◽  
Michael A. Levine

Myostatin negatively regulates muscle growth and development and has recently been characterized in several fishes. We measured fasting myostatin mRNA levels in adult tilapia skeletal muscle and in whole larvae. Although fasting reduced some growth indexes in adults, skeletal muscle myostatin mRNA levels were unaffected. By contrast, larval myostatin mRNA levels were sometimes elevated after a short-term fast and were consistently reduced with prolonged fasting. These effects were specific for myostatin, as mRNA levels of glyceraldehyde-3-phosphate dehydrogenase and glucose-6-phosphatase were unchanged. Cortisol levels were elevated in fasted larvae with reduced myostatin mRNA, whereas in addition immersion of larvae in 1 ppm (2.8 μM) cortisol reduced myostatin mRNA in a time-dependent fashion. These results suggest that larval myostatin mRNA levels may initially rise but ultimately fall during a prolonged fast. The reduction is likely mediated by fasting-induced hypercortisolemia, indicating divergent evolutionary mechanisms of glucocorticoid regulation of myostatin mRNA, since these steroids upregulate myostatin gene expression in mammals.


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