Parathyroid carcinoma in multiple endocrine neoplasia type 1 (MEN1) syndrome: Two case reports of an unrecognised entity

2007 ◽  
Vol 30 (2) ◽  
pp. 145-149 ◽  
Author(s):  
A. Agha ◽  
R. Carpenter ◽  
S. Bhattacharya ◽  
S. J. Edmonson ◽  
E. Carlsen ◽  
...  
Keyword(s):  
Parathyroid Carcinoma ◽  
Multiple Endocrine Neoplasia ◽  
Multiple Endocrine Neoplasia Type ◽  
Case Reports ◽  
Men1 Syndrome ◽  
Endocrine Neoplasia ◽  
Endocrine Neoplasia Type

A complex case of Multiple Endocrine Neoplasia type 1 with Metastatic Parathyroid Carcinoma

Open Medicine ◽  
2010 ◽  
Vol 5 (1) ◽  
pp. 53-58 ◽  
Author(s):  
Shyam Kalavalapalli ◽  
Indrajit Talapatra ◽  
Ian Connell
Keyword(s):  
Clinical Features ◽  
Parathyroid Carcinoma ◽  
Multiple Endocrine Neoplasia ◽  
Multiple Endocrine Neoplasia Type ◽  
Somatostatin Analogues ◽  
Complex Case ◽  
Endocrine Neoplasia ◽  
Endocrine Neoplasia Type ◽  
Gut Hormone

AbstractWe describe below a patient with Multiple Endocrine Neoplasia type 1 (MEN type 1) who presented with features of Primary Hyperparathyroidism. However, the actual diagnosis of Parathyroid Carcinoma was delayed until metastases to the lung were discovered. She was also found to have Pituitary Macro adenoma with Silent Acromegaly, with no clinical features whatsoever. She underwent transphenoidal hypophysectomy with postoperative radiotherapy. However, the disease process remained biochemically active necessitating commencement of somatostatin analogues. There is also a tumour at the head of the pancreas which at present is non functional with normal gut hormone profile and normal 24 hour urinary 5-hydroxyl indole acetic acid (5-HIAA) excretion assay. Our case highlights the pitfalls in diagnosing the parathyroid carcinoma due to lack of initial proper histological features. The diagnosis of parathyroid carcinoma was based on histologically confirmed metastases to the lungs. We also discuss below the entity called Silent Acromegaly where patients have biochemically and/or histologically confirmed growth Hormone (GH) excess with no clinical features suggesting Acromegaly. We discuss the benefits of somatostatin analogues in indirectly controlling the rest of the tumours in MEN1 and hypothesise the same for metastatic parathyroid carcinoma. Metastatic parathyroid carcinoma with multiple endocrine neoplasia type 1 is extremely rare. Our case highlights the complexities of managing MEN1 with metastatic parathyroid carcinoma and the dilemmas in dealing with the various aspects of the care.

Parathyroid Carcinoma in Multiple Endocrine Neoplasia Type 1 with a Classic Germline Mutation

2009 ◽  
Vol 15 (6) ◽  
pp. 567-572 ◽  
Author(s):  
Roger Shih ◽  
Sarah Fackler ◽  
Stephen Maturo ◽  
Mark True ◽  
Joseph Brennan ◽  
...  
Keyword(s):  
Germline Mutation ◽  
Parathyroid Carcinoma ◽  
Multiple Endocrine Neoplasia ◽  
Multiple Endocrine Neoplasia Type ◽  
Endocrine Neoplasia ◽  
Endocrine Neoplasia Type

scholarly journals Nonfunctional Metastatic Parathyroid Carcinoma in the Setting of Multiple Endocrine Neoplasia Type 2A Syndrome

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
María Posada-González ◽  
Joaquín Gómez-Ramírez ◽  
Manuel Luque-Ramírez ◽  
Mercedes Guijarro ◽  
Elena Martín-Pérez ◽  
...  
Keyword(s):  
Primary Hyperparathyroidism ◽  
Parathyroid Carcinoma ◽  
Multiple Endocrine Neoplasia ◽  
Multiple Endocrine Neoplasia Type ◽  
Medullary Thyroid ◽  
Endocrine Neoplasia ◽  
Endocrine Neoplasia Type ◽  
Rare Malignancy ◽  
Men 2A

Parathyroid carcinoma is a very rare malignancy. It has been associated with hyperparathyroidism-jaw tumour syndrome, familial isolated primary hyperparathyroidism, and multiple endocrine neoplasia type 1 (MEN-1) and 2A (MEN-2A) syndromes. We report a 54-year-old man with a MEN-2A which presents with a nonfunctional metastatic parathyroid carcinoma and a pheochromocytoma in the absence of medullary thyroid carcinoma. Only a few cases of parathyroid carcinoma have been reported in the literature associated with this syndrome.

scholarly journals Parathyroid carcinoma in multiple endocrine neoplasia type 1. Case report and review of the literature

HORMONES ◽  
2011 ◽  
Vol 10 (4) ◽  
pp. 326-331 ◽  
Author(s):  
Carlos del Pozo ◽  
Luis García-Pascual ◽  
Montserrat Balsells ◽  
María-José Barahona ◽  
Enrique Veloso ◽  
...  
Keyword(s):  
Case Report ◽  
Parathyroid Carcinoma ◽  
Multiple Endocrine Neoplasia ◽  
Multiple Endocrine Neoplasia Type ◽  
Review Of The Literature ◽  
Endocrine Neoplasia ◽  
Endocrine Neoplasia Type

scholarly journals Genetic confirmation that ependymoma can arise as part of multiple endocrine neoplasia type 1 (MEN1) syndrome

2017 ◽  
Vol 133 (4) ◽  
pp. 661-663 ◽  
Author(s):  
Areli K. Cuevas-Ocampo ◽  
Andrew W. Bollen ◽  
Benjamin Goode ◽  
Kristian W. Pajtler ◽  
Lukas Chavez ◽  
...  
Keyword(s):  
Multiple Endocrine Neoplasia ◽  
Multiple Endocrine Neoplasia Type ◽  
Men1 Syndrome ◽  
Endocrine Neoplasia ◽  
Endocrine Neoplasia Type
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