Acetyl-L-carnitine (ALC) administration positively affects reproductive axis in hypogonadotropic women with functional hypothalamic amenorrhea

2010 ◽  
Vol 34 (4) ◽  
pp. 287-291 ◽  
Author(s):  
A. D. Genazzani ◽  
C. Lanzoni ◽  
F. Ricchieri ◽  
S. Santagni ◽  
E. Rattighieri ◽  
...  
Keyword(s):  
Hypothalamic Amenorrhea ◽  
Reproductive Axis ◽  
Functional Hypothalamic Amenorrhea

scholarly journals Kisspeptin and LH pulsatility in patients with functional hypothalamic amenorrhea

Endocrine ◽  
2020 ◽  
Vol 70 (3) ◽  
pp. 635-643
Author(s):  
Agnieszka Podfigurna ◽  
Marzena Maciejewska-Jeske ◽  
Blazej Meczekalski ◽  
Alessandro D. Genazzani
Keyword(s):  
Weight Loss ◽  
Body Weight ◽  
Total Cholesterol ◽  
Body Weight Loss ◽  
Hypothalamic Amenorrhea ◽  
Reproductive Axis ◽  
Lh Pulsatility ◽  
Functional Hypothalamic Amenorrhea ◽  
Temporal Coupling ◽  
Hydroxy Progesterone

Abstract Purpose Functional hypothalamic amenorrhea (FHA) occurs in response to exaggerated stressors with or without body weight loss. Various hormones, neurotransmitters, and neuromodulators are involved in the control of GnRH and kisspeptin is one of them. Our study aimed to evaluate the putative temporal coupling between kisspeptin and GnRH-induced LH pulsatile secretion. Methods In total, 71 patients with FHA were selected for this study. All patients undergo to a pulsatility study for LH and kisspeptin evaluation (120 min, sampling every 10 min), and to an endocrine evaluation for prolactin (PRL), estradiol (E2), androstenedione (A), 17-hydroxy-progesterone (17OHP), TSH, fT3, fT4, insulin, cortisol and testosterone (T), glucose, total cholesterol, triglycerides. Results Our data demonstrated kisspeptin and LH pulsatile secretions and that both hormones are co-secreted and temporally coupled at time 0 (p < 0.05). When patients were subdivided in hypo-LH (≤3 mIU/ml, n = 58) and normo-LH (>3 mIU/ml, n = 13), more insights were observed on the specific correlations of metabolic and hormone profiles with pulsatility indexes of LH and kisspeptin. Conclusions Our study demonstrated the presence of a distinct kisspeptin episodic secretion in patients with FHA, and showed the temporally coupling of kisspeptin with LH secretory episodes thus supporting that though in amenorrhea, the reproductive axis is still relying on kisspeptin to drive GnRH discharge. In addition, correlations among hormonal data sustain the hypothesis that stress-induced compensatory events are the main direct and indirect promoters of the reproductive blockade in patients affected by FHA.

scholarly journals Administration of Very Low Doses of Estradiol Modulates the LH Response to a GnRH Bolus and the LH and Cortisol Responses to Naloxone Infusion in Patients with Functional Hypothalamic Amenorrhea (FHA): A Pilot Study

Endocrines ◽  
2020 ◽  
Vol 1 (1) ◽  
pp. 35-45
Author(s):  
Alessandro D. Genazzani ◽  
Giulia Despini ◽  
Alessia Prati ◽  
Alba Manzo ◽  
Tabatha Petrillo ◽  
...  
Keyword(s):  
Low Dose ◽  
Cortisol Response ◽  
Hypothalamic Amenorrhea ◽  
Gonadotropin Secretion ◽  
Neuroendocrine Function ◽  
Reproductive Axis ◽  
Functional Hypothalamic Amenorrhea ◽  
Before And After ◽  
Response And Recovery ◽  
Cortisol Responses

Background: Functional Hypothalamic Amenorrhea (FHA) is a stress-induced blockade of the reproductive axis. Such impairment is mainly due to altered control of GnRH-induced gonadotropin secretion as well as alterations of other endocrine functions. Methods: Seventeen patients with FHA participated in the study. Basal hormonal profiles and GnRH and Naloxone tests for LH (Luteinizing Hormone) and for LH and cortisol responses, respectively, were performed before and after two weeks of administration of a very low dose of estradiol (2.5 ng two times a day). Results: The treatment improved both gonadotropins, mainly LH. The LH response to the GnRH test improved in terms of the peak amplitude, as evaluated using Instantaneous Secretory Rates (ISR) computation. Moreover, when performing the Naloxone test after the treatment interval, FHA patients showed a quicker LH response and recovery of the cortisol response. Conclusions: Our study supports the relevance of very low dose estradiol priming to promote and restore impaired neuroendocrine function in patients with FHA.

Bone mineral density in girls with functional hypothalamic amenorrhea subjected to estroprogestagen treatment: a 4-year prospective study

2014 ◽  
Author(s):  
Elzbieta Sowinska-Przepiera ◽  
Elzbieta Andrysiak-Mamos ◽  
Agnieszka Kazmierczyk-Puchalska ◽  
Ewa Wentland-Kotwicka ◽  
Anhelli Syrenicz
Keyword(s):  
Bone Mineral Density ◽  
Prospective Study ◽  
Bone Mineral ◽  
Mineral Density ◽  
Hypothalamic Amenorrhea ◽  
Functional Hypothalamic Amenorrhea

Short-term estriol administration modulates hypothalamo-pituitary function in patients with functional hypothalamic amenorrhea (FHA)

2015 ◽  
Vol 32 (3) ◽  
pp. 253-257 ◽  
Author(s):  
Alessandro D. Genazzani ◽  
Agnieszka Podfigurna-Stopa ◽  
Adam Czyzyk ◽  
Krzysztof Katulski ◽  
Alessia Prati ◽  
...  
Keyword(s):  
Pituitary Function ◽  
Short Term ◽  
Hypothalamic Amenorrhea ◽  
Functional Hypothalamic Amenorrhea

scholarly journals Clinical, biological presentation of six cases of functional hypothalamic amenorrhea

2017 ◽  
Vol 6 (5) ◽  
pp. 3787-3790
Author(s):  
Zeghdar Moufida ◽  
◽  
Dahbia Ines Dahmani ◽  
Chiha Fouad ◽  
Benfetima Zohra ◽  
...  
Keyword(s):  
Hypothalamic Amenorrhea ◽  
Functional Hypothalamic Amenorrhea
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