Serum concentrations of selected endogenous estrogen and estrogen metabolites in pre- and post-menopausal Chinese women with osteoarthritis

2010 ◽  
Vol 33 (9) ◽  
pp. 644-649 ◽  
Author(s):  
W. Gao ◽  
C. Zeng ◽  
D. Cai ◽  
B. Liu ◽  
Y. Li ◽  
...  
Keyword(s):  
Chinese Women ◽  
Serum Concentrations ◽  
Estrogen Metabolites ◽  
Endogenous Estrogen ◽  
Post Menopausal

scholarly journals Role of plasminogen activator inhibitor-1 gene polymorphisms in osteoporosis: A study in Chinese post-menopausal women

2018 ◽  
Vol 16 ◽  
pp. 205873921876729
Author(s):  
An Wan ◽  
Daodong Liu
Keyword(s):  
Gene Polymorphisms ◽  
Chinese Women ◽  
Plasminogen Activator Inhibitor ◽  
Plasminogen Activator Inhibitor 1 ◽  
Chain Reaction ◽  
Polymerase Chain ◽  
Post Menopausal ◽  
Activator Inhibitor ◽  
Pai 1

Osteoporosis is a chronic multifactorial disease characterized by deterioration of bone mass and is vulnerable to bone fracture. Plasminogen activator inhibitor-1 (PAI-1) is an important molecule for maintenance of optimum bone mass. Several single-nucleotide polymorphisms (SNPs) in PAI-1 have been reported to alter PAI-1 expression and/or the translational level. In this report, we explored the possible role of common PAI-1 gene polymorphisms on predisposition to osteoporosis in a Chinese cohort. A total of 364 post-menopausal Chinese women diagnosed of having osteoporosis and 350 healthy females hailing from similar areas were enrolled in this study. Five common SNPs (−844G > A, −6754G/5G, +43G > A, +9785G > A and +11053T > G) were genotyped by polymerase chain reaction (PCR) followed by restriction fragment length polymorphism (RFLP). Relative expression of PAI-1 mRNA and plasma PAI-1 levels were quantified by reverse transcription polymerase chain reaction (RT-PCR) and enzyme-linked immunosorbent assay (ELISA), respectively. Prevalence of homozygous mutant (5G/5G) and minor allele (5G) of PAI-1 (−675 4G/5G) polymorphism was significantly more frequent in patients than in healthy controls (5G/5G: P < 0.0001, odds ratio (OR) = 3.18; 5G: P < 0.0001, OR = 1.65). Both plasma PAI-1 and relative mRNA expression levels were significantly lower in patients compared to healthy controls. Interestingly, the quantity of plasma PAI-1 and mRNA expression was correlated with PAI-1 (−675 4G/5G) polymorphism: subjects with 4G/4G genotype had elevated PAI-1 in comparison to homozygous mutant, and displayed lower quantity of PAI-1 protein and mRNA values. PAI-1 (−675 4G/5G) mutant is associated with susceptibility to development of osteoporosis in post-menopausal Chinese women. Furthermore, this variant in the promoter region alters plasma protein levels and relative expression of PAI-1.

Clinical outcomes of post-operative locoregional radiotherapy in pre-menopausal and post-menopausal Chinese women with breast cancer

2000 ◽  
Vol 54 (3) ◽  
pp. 201-208 ◽  
Author(s):  
Tony S.K Mok ◽  
Wing Hong Kwan ◽  
Winnie M Yeo ◽  
Anthony T.C Chan ◽  
Edmund C.K Chan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Clinical Outcomes ◽  
Chinese Women ◽  
Post Menopausal

Relationship between endogenous estrogen concentrations and serum cholesteryl ester transfer protein concentrations in Chinese women

2001 ◽  
Vol 314 (1-2) ◽  
pp. 77-83 ◽  
Author(s):  
Chunni Zhang ◽  
Yiyi Zhuang ◽  
Hongjuan Qiang ◽  
Xiaozhuan Liu ◽  
Ruiji Xu ◽  
...  
Keyword(s):  
Cholesteryl Ester ◽  
Cholesteryl Ester Transfer Protein ◽  
Chinese Women ◽  
Transfer Protein ◽  
Endogenous Estrogen

scholarly journals Snoring is associated with body composition in （peri-post）menopausal women

2019 ◽  
Author(s):  
minfang tao ◽  
yang zhou ◽  
fei liu ◽  
changbin li ◽  
yanwei zheng ◽  
...  
Keyword(s):  
Body Composition ◽  
Fat Mass ◽  
Chinese Women ◽  
Bioelectrical Impedance ◽  
Impedance Analysis ◽  
Menopausal Transition ◽  
Cross Sectional ◽  
Obstructive Sleep ◽  
Menopausal Women ◽  
Post Menopausal

Abstract Background: Little attention has been paid to whether snoring frequency is associated with body composition in menopausal women, particularly in China. This study objected to investigate the association between self-reported snoring and body composition in (peri-post) menopausal Chinese women as well as glucose/lipid metabolic indicators. Methods: This cross-sectional study enrolled 715 participants aged 40-67 years from the Menopause Clinic in the Shanghai Sixth People’s Hospital. Participants were categorized into four subgroups stratified by self-reported snoring frequency: never, rarely (<1 night per week), occasionally (1-2 nights per week), regularly (≥3 nights per week), while body composition was measured using bioelectrical impedance analysis(BIA).Besides, blood sample were collected to test the glycolipid indicators. Results: In our sample of investigation, regular snoring (≥3 nights per week) was found to be an independent risk factor for higher fat mass (total, upper limbs, trunk), with the highest risk of 2.4 times for fat mass of trunk after adjusting for glucose/lipid metabolic confounders(p=0.003). Meanwhile, regular snoring was independently associated with higher fat mass (total and each segment) only in the menopausal transition (p=0.023). Conclusion: We suggested that self-reported regular snoring may be taken as a simple alternative to predict higher fat mass (≥17.11kg, upper quartile) in menopausal women. Similarly, body composition should be attached to the great importance to those who in menopausal transition in order to help to prevent obstructive sleep apnea(OSA).

Organochlorines in Chinese Women: Determinants of Serum Concentrations

2011 ◽  
Vol 183-185 ◽  
pp. 1513-1516
Author(s):  
Wu Wen Lv
Keyword(s):  
Heavy Metals ◽  
Serum Level ◽  
Organochlorine Pesticides ◽  
Organic Pollutants ◽  
Chinese Women ◽  
Serum Levels ◽  
High Serum ◽  
Environmental Chemicals ◽  
Serum Concentrations ◽  
High Serum Level

People are frequently exposed to various environmental chemicals such as organic pollutants, heavy metals, etc. Therefore, the aim of this paper is to investigate the accumulation level of organochlorines in women from Qiqihaer city in china. Of the 160 people investigated, 113 sujects were detected with different serum levels of organochlorine pesticides (range: 0.042 - 33.072 μg/L). Moreover, the results indicated that there was high serum level of accumulated organochlorines pesticides of women in Chinese, and the serum concentrations of organochlorines pesticides was associated with age.

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