Use of radioguided surgery with [111In]-pentetreotide in the management of an ACTH-secreting bronchial carcinoid causing ectopic Cushing’s syndrome

2005 ◽  
Vol 28 (3) ◽  
pp. 72-78 ◽  
Author(s):  
E. Grossrubatscher ◽  
F. Vignati ◽  
P. Dalino ◽  
M. Possa ◽  
P. A. Belloni ◽  
...  
Keyword(s):  
Cushing’S Syndrome ◽  
Cushing's Syndrome ◽  
Radioguided Surgery ◽  
Bronchial Carcinoid ◽  
Ectopic Cushing’S Syndrome ◽  
Acth Secreting

DETECTION OF AN ACTH-SECRETING BRONCHIAL CARCINOID TUMOUR EIGHTEEN MONTHS AFTER ADRENALECTOMY FOR CUSHING'S SYNDROME

1971 ◽  
Vol 67 (4) ◽  
pp. 625-633 ◽  
Author(s):  
A. C. M. Vingerhoeds ◽  
P. J. der Kinderen ◽  
J. H. H. Thijssen ◽  
F. Schwarz
Keyword(s):  
Differential Diagnosis ◽  
Cushing’S Syndrome ◽  
Carcinoid Tumour ◽  
Cushing's Syndrome ◽  
Bronchial Carcinoid ◽  
Laboratory Methods ◽  
Ectopic Cushing’S Syndrome ◽  
Course Of Action ◽  
Ablative Surgery ◽  
Acth Secreting

ABSTRACT A patient is described in whom an ACTH-producing bronchial carcinoid tumour was found eighteen months after bilateral adrenalectomy for Cushing's syndrome. A critical review is given of laboratory methods used in the differential diagnosis of ectopic Cushing's syndrome. Finally a course of action is suggested by which such unnecessary ablative surgery might be avoided.

Diagnosis and radioguided surgery with 111In-pentetreotide in a patient with paraneoplastic Cushing's syndrome due to a bronchial carcinoid

1997 ◽  
pp. 688-690 ◽  
Author(s):  
L Mansi ◽  
PF Rambaldi ◽  
N Panza ◽  
D Esposito ◽  
V Esposito ◽  
...  
Keyword(s):  
Lymph Node ◽  
Cushing’S Syndrome ◽  
Somatostatin Receptors ◽  
Cushing's Syndrome ◽  
Ectopic Acth Syndrome ◽  
Radioguided Surgery ◽  
Bronchial Carcinoid ◽  
Ectopic Acth ◽  
The Right ◽  
Acth Secreting

In a 28-year-old man with Cushing's syndrome, studies investigating a hypophyseal and/or adrenal origin of the disease, including computed tomography and magnetic resonance imaging, were negative. In agreement with reports showing somatostatin receptors on the cell membrane of ectopically secreting ACTH tumours, scintigraphy was performed after intravenous injection of 111 MBq 111In-pentetreotide (OCT). The radiolabelled OCT scan showed a small focal area of intense uptake at the inferior lobe of the right lung. Subsequent radioguided surgery located and defined a small mass (1.8 x 1.4 x 1.6 cm). The probe pinpointed the mass to the right inferior chest lobe, with a tumour/normal tissue count ratio of 6:1 and tumour/hilar normal lymph node ratio of 12:1, thus permitting the complete excision of the tumour to exclude lymph node and/or parietal involvement. A lung carcinoid was diagnosed at histology. The patient is still alive and disease-free 24 months after surgery. 111In-OCT was found to be useful for localizing the ACTH-secreting tumour and also permitted rapid non-invasive differential diagnosis between an ACTH-secreting pituitary adenoma and malignancy causing ectopic ACTH syndrome. This study also showed the clinical usefulness of radioguided surgery in the treatment of bronchial carcinoid.

Plurihormonal bronchial carcinoid associated with ectopic Cushing’s syndrome

1999 ◽  
Vol 10 (4) ◽  
pp. 359-365 ◽  
Author(s):  
Donna Battaglia ◽  
Kalman Kovacs ◽  
Eva Horvath ◽  
Eric Poulin ◽  
Harley S. Smyth
Keyword(s):  
Cushing’S Syndrome ◽  
Cushing's Syndrome ◽  
Bronchial Carcinoid ◽  
Ectopic Cushing’S Syndrome

scholarly journals Severe Ectopic Cushing’s Syndrome Due to ACTH-Secreting Pheochromocytoma

2013 ◽  
Vol 04 (04) ◽  
pp. 228-231 ◽  
Author(s):  
Aurelio Negro ◽  
Enrica Manicardi ◽  
Chiara Grasselli ◽  
Massimiliano Babini ◽  
Rosaria Santi ◽  
...  
Keyword(s):  
Cushing’S Syndrome ◽  
Cushing's Syndrome ◽  
Ectopic Cushing’S Syndrome ◽  
Acth Secreting

Failure of Somatostatin Analogue Sms 201–995 to Control Cushing's Syndrome Due to Ectopic Release of Acth from a Bronchial Carcinoid

1989 ◽  
Vol 34 (5) ◽  
pp. 533-534 ◽  
Author(s):  
L. Burrell ◽  
C.E. Gray ◽  
J.A. Thomson
Keyword(s):  
Cushing’S Syndrome ◽  
Carcinoid Tumour ◽  
Cushing's Syndrome ◽  
Somatostatin Analogue ◽  
Bronchial Carcinoid ◽  
Thymic Carcinoid ◽  
Ectopic Cushing’S Syndrome

A patient with ectopic Cushing's syndrome secondary to a malignant thymic carcinoid tumour was treated with the somatostatin analogue SMS 201–995. The administration of the drug subcutaneously in increasing doses over a 34 day period failed to control the ACTH or glucocorticoid excess.

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