Ontogeny and regulation of variant thyroid hormone receptor isoforms in developing rat testis

1999 ◽  
Vol 22 (11) ◽  
pp. 843-848 ◽  
Author(s):  
E. A. Jannini ◽  
E. Carosa ◽  
N. Rucci ◽  
E. Screponi ◽  
M. D’Armiento
Keyword(s):  
Thyroid Hormone ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
Rat Testis ◽  
Receptor Isoforms ◽  
Developing Rat

Coexpression of thyroid hormone receptor isoforms in mouse oligodendrocytes

2001 ◽  
Vol 67 (1) ◽  
pp. 106-113 ◽  
Author(s):  
Fabienne Bury ◽  
Jean-Luc Carré ◽  
Sonia Vega ◽  
M. Said Ghandour ◽  
Angeles Rodriguez-Peña ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
Receptor Isoforms

Thyroid hormone receptor isoforms localize to cardiac mitochondrial matrix with potential for binding to receptor elements on mtDNA

Mitochondrion ◽  
2006 ◽  
Vol 6 (3) ◽  
pp. 143-148 ◽  
Author(s):  
Fionnuala Morrish ◽  
Norman E. Buroker ◽  
Ming Ge ◽  
Xue-Han Ning ◽  
Jesus Lopez-Guisa ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
Mitochondrial Matrix ◽  
Receptor Isoforms

scholarly journals Thyroid-hormone-dependent negative regulation of thyrotropin beta gene by thyroid hormone receptors: study with a new experimental system using CV1 cells

2004 ◽  
Vol 378 (2) ◽  
pp. 549-557 ◽  
Author(s):  
Keiko NAKANO ◽  
Akio MATSUSHITA ◽  
Shigekazu SASAKI ◽  
Hiroko MISAWA ◽  
Kozo NISHIYAMA ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Hormone Receptor ◽  
Hormone Receptors ◽  
Thyroid Hormone Receptor ◽  
Experimental System ◽  
Thyroid Stimulating Hormone ◽  
Negative Regulation ◽  
Dominant Negative ◽  
Negative Effects ◽  
Receptor Isoforms

The molecular mechanism involved in the liganded thyroid hormone receptor suppression of the TSHβ (thyroid-stimulating hormone β, or thyrotropin β) gene transcription is undetermined. One of the main reasons is the limitation of useful cell lines for the experiments. We have developed an assay system using non-pituitary CV1 cells and studied the negative regulation of the TSHβ gene. In CV1 cells, the TSHβ–CAT (chloramphenicol acetyltransferase) reporter was stimulated by Pit1 and GATA2 and suppressed by T3 (3,3´,5-tri-iodothyronine)-bound thyroid hormone receptor. The suppression was dependent on the amounts of T3 and the receptor. Unliganded receptor did not stimulate TSHβ activity, suggesting that the receptor itself is not an activator. Analyses using various receptor mutants revealed that the intact DNA-binding domain is crucial to the TSHβ gene suppression. Co-activators and co-repressors are not necessarily essential, but are required for the full suppression of the TSHβ gene. Among the three receptor isoforms, β2 exhibited the strongest inhibition and its protein level was the most predominant in a thyrotroph cell line, TαT1, in Western blotting. The dominant-negative effects of various receptor mutants measured on the TSHβ–CAT reporter were not simple mirror images of those in the positive regulation under physiological T3 concentration.

Thyroid hormone receptor isoforms are sequentially expressed in oligodendrocyte lineage cells during rat cerebral development

1998 ◽  
Vol 54 (5) ◽  
pp. 584-594 ◽  
Author(s):  
Jean-Luc Carr� ◽  
Corinne Demerens ◽  
Angeles Rodr�guez-Pe�a ◽  
Herv� H. Floch ◽  
Guy Vincendon ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
Cerebral Development ◽  
Receptor Isoforms

scholarly journals Structural basis of GC-1 selectivity for thyroid hormone receptor isoforms

2008 ◽  
Vol 8 (1) ◽  
pp. 8 ◽  
Author(s):  
Lucas Bleicher ◽  
Ricardo Aparicio ◽  
Fabio M Nunes ◽  
Leandro Martinez ◽  
Sandra M Gomes Dias ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
Structural Basis ◽  
Receptor Isoforms

Regulation of expression of thyroid hormone receptor isoforms and coactivators in liver and heart by thyroid hormone

2003 ◽  
Vol 203 (1-2) ◽  
pp. 65-75 ◽  
Author(s):  
Peter M. Sadow ◽  
Olivier Chassande ◽  
Eugene K. Koo ◽  
Karine Gauthier ◽  
Jacques Samarut ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
Regulation Of Expression ◽  
Receptor Isoforms
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