Age-related bone loss and senile osteoporosis: Evidence for both secondary hyperparathyroidism and skeletal growth factor deficiency in the elderly

1995 ◽  
Vol 7 (6) ◽  
pp. 414-422 ◽  
Author(s):  
S. Boonen ◽  
J. Aerssens ◽  
P. Broos ◽  
W. Pelemans ◽  
J. Dequeker
Keyword(s):  
Growth Factor ◽  
Bone Loss ◽  
Secondary Hyperparathyroidism ◽  
The Elderly ◽  
Skeletal Growth ◽  
Senile Osteoporosis ◽  
Age Related ◽  
Factor Deficiency ◽  
Skeletal Growth Factor

scholarly journals The Dual Role of Vitamin K2 in “Bone-Vascular Crosstalk”: Opposite Effects on Bone Loss and Vascular Calcification

Nutrients ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 1222
Author(s):  
Domitilla Mandatori ◽  
Letizia Pelusi ◽  
Valeria Schiavone ◽  
Caterina Pipino ◽  
Natalia Di Pietro ◽  
...  
Keyword(s):  
Bone Loss ◽  
Vascular Calcification ◽  
Vascular System ◽  
The Elderly ◽  
Food Supplement ◽  
Vitamin K2 ◽  
Bioactive Molecules ◽  
Calcium Deposition ◽  
Age Related

Osteoporosis (OP) and vascular calcification (VC) represent relevant health problems that frequently coexist in the elderly population. Traditionally, they have been considered independent processes, and mainly age-related. However, an increasing number of studies have reported their possible direct correlation, commonly defined as “bone-vascular crosstalk”. Vitamin K2 (VitK2), a family of several natural isoforms also known as menaquinones (MK), has recently received particular attention for its role in maintaining calcium homeostasis. In particular, VitK2 deficiency seems to be responsible of the so-called “calcium paradox” phenomenon, characterized by low calcium deposition in the bone and its accumulation in the vessel wall. Since these events may have important clinical consequences, and the role of VitK2 in bone-vascular crosstalk has only partially been explained, this review focuses on its effects on the bone and vascular system by providing a more recent literature update. Overall, the findings reported here propose the VitK2 family as natural bioactive molecules that could be able to play an important role in the prevention of bone loss and vascular calcification, thus encouraging further in-depth studies to achieve its use as a dietary food supplement.

scholarly journals Age-Related Femoral Bone Loss in Men: Evidence for Hyperparathyroidism and Insulin-Like Growth Factor-1 Deficiency

2004 ◽  
Vol 59 (12) ◽  
pp. 1285-1289 ◽  
Author(s):  
H. Blain ◽  
A. Vuillemin ◽  
A. Blain ◽  
F. Guillemin ◽  
N. D. Talance ◽  
...  
Keyword(s):  
Growth Factor ◽  
Bone Loss ◽  
Insulin Like Growth Factor ◽  
Femoral Bone ◽  
Age Related

scholarly journals Age-Related Changes in the 25-Hydroxyvitamin D Versus Parathyroid Hormone Relationship Suggest a Different Reason Why Older Adults Require More Vitamin D

2003 ◽  
Vol 88 (1) ◽  
pp. 185-191 ◽  
Author(s):  
Reinhold Vieth ◽  
Yasmin Ladak ◽  
Paul G. Walfish
Keyword(s):  
Older Adults ◽  
Vitamin D ◽  
Secondary Hyperparathyroidism ◽  
Age Groups ◽  
The Elderly ◽  
Age Group ◽  
Hydroxyvitamin D ◽  
Age Related ◽  
25 Hydroxyvitamin D ◽  
The Relationship

Vitamin D requirements are thought to vary with age, but there is little comparative evidence for this. One goal in establishing a vitamin D requirement is to avoid secondary hyperparathyroidism. We studied 1741 euthyroid, thyroid clinic outpatients without evidence of calcium abnormalities, ranging in age from 19 to 97 yr, whose serum and urine had been analyzed for calcium, vitamin D, and parathyroid status. We found no effect of age on the 25-hydroxyvitamin D [25(OH)D] concentration associated with specific vitamin D intakes, and there was no relationship between 25(OH)D and 1,25hydroxyvitamin D [1,25(OH)2D]. In every age group, serum 1,25(OH)2D declined with increasing creatinine (P < 0.001). What changed with age included creatinine, which correlated with 25(OH)D (r = 0.146, P < 0.001) only in the youngest age group (19–50 yr) but not in the older age groups (P > 0.1). Creatinine did not correlate with PTH in the youngest age group, but the relationship became significant as age increased (e.g. for the elderly, r = 0.365, P < 0.001). Linear regression of log PTH vs. log 25(OH)D agreed with the natural shape of the relationship observed with scatterplot smoothing, and this showed no plateau in PTH as 25(OH)D increased. We compared PTH concentrations among age groups, based on 20 nmol/liter increments in 25(OH)D. Mean PTH in adults older than 70 yr was consistently higher than in adults younger than 50 yr (P < 0.05 by ANOVA and Dunnett’s t test). PTH levels of the elderly who had 25(OH)D concentrations greater than 100 nmol/liter matched PTH of younger adults having 25(OH)D concentrations near 70 nmol/liter. This study shows that all age groups exhibit a high prevalence of 25(OH)D insufficiency and secondary hyperparathyroidism. Older adults are just as efficient in maintaining 25(OH)D, but they need more vitamin D to produce the higher 25(OH)D concentrations required to overcome the hyperparathyroidism associated with their diminishing renal function.

Purification of a skeletal growth factor from human bone

Biochemistry ◽  
1982 ◽  
Vol 21 (14) ◽  
pp. 3502-3507 ◽  
Author(s):  
John R. Farley ◽  
David J. Baylink
Keyword(s):  
Growth Factor ◽  
Human Bone ◽  
Skeletal Growth ◽  
Skeletal Growth Factor

Human skeletal growth factor isolated

Science ◽  
1982 ◽  
Vol 217 (4562) ◽  
pp. 819-819 ◽  
Author(s):  
T. Maugh
Keyword(s):  
Growth Factor ◽  
Skeletal Growth ◽  
Skeletal Growth Factor

scholarly journals Modeling the Mechanical Consequences of Age-Related Trabecular Bone Loss by XFEM Simulation

2016 ◽  
Vol 2016 ◽  
pp. 1-12 ◽  
Author(s):  
Ruoxun Fan ◽  
He Gong ◽  
Xianbin Zhang ◽  
Jun Liu ◽  
Zhengbin Jia ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Bone Loss ◽  
Trabecular Bone ◽  
Bone Age ◽  
The Elderly ◽  
Extended Finite Element ◽  
Age Related ◽  
Trabecular Bone Loss ◽  
Complete Failure ◽  
Fracture Processes

The elderly are more likely to suffer from fracture because of age-related trabecular bone loss. Different bone loss locations and patterns have different effects on bone mechanical properties. Extended finite element method (XFEM) can simulate fracture process and was suited to investigate the effects of bone loss on trabecular bone. Age-related bone loss is indicated by trabecular thinning and loss and may occur at low-strain locations or other random sites. Accordingly, several ideal normal and aged trabecular bone models were created based on different bone loss locations and patterns; then, fracture processes from crack initiation to complete failure of these models were observed by XFEM; finally, the effects of different locations and patterns on trabecular bone were compared. Results indicated that bone loss occurring at low-strain locations was more detrimental to trabecular bone than that occurring at other random sites; meanwhile, the decrease in bone strength caused by trabecular loss was higher than that caused by trabecular thinning, and the effects of vertical trabecular loss on mechanical properties were more severe than horizontal trabecular loss. This study provided a numerical method to simulate trabecular bone fracture and distinguished different effects of the possible occurrence of bone loss locations and patterns on trabecular bone.

scholarly journals Factores de diferenciación génica y su futuro en el tratamiento de la osteoporosis: de la adipogénesis a la osteoblastogénesis, ¿del mismo modo y en sentido contrario?

2018 ◽  
Vol 5 (4) ◽  
pp. 21-25
Author(s):  
Pedro Sánchez Márquez ◽  
Carlos Arturo Révérend Lizcano
Keyword(s):  
Transcription Factor ◽  
Bone Loss ◽  
Bone Formation ◽  
Endochondral Ossification ◽  
Related Factors ◽  
Senile Osteoporosis ◽  
Age Related ◽  
Post Traumatic

El presente artículo tiene como objetivo presentar de forma resumida los diferentes factores que están involucrados en la diferenciación y el mantenimiento del fenotipo óseo, en contraste con los factores adipogénicos, cuya expresión determina procesos de diferenciación mutuamente excluyentes. Por otro lado, se propone el posible uso terapéutico para distintas patologías óseas como la osteoporosis. Los datos fueron obtenidos de estudios clínicos aleatorizados y de revisión, en idioma español e inglés, de los últimos 15 años, que incluyeran los términos Mesh: Osteoporosis; Osteoporoses; Osteoporosis, Post-Traumatic; Osteoporosis, Senile; Osteoporosis, Age-Related; Bone Loss, Age-Related; Factors, Transcription; Transcription Factor; Adipogeneses; Bone Formation; Osteoclastogenesis; Endochondral Ossification; Endochondral Ossifications; Ossification, Endochondral; Ossification, Physiological; Ossification, Physiologic.

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