The role of calcium regulation in brain aging: reexamination of a hypothesis

1989 ◽  
Vol 1 (1) ◽  
pp. 17-34 ◽  
Author(s):  
Zaven S. Khachaturian
Keyword(s):  
Brain Aging ◽  
Calcium Regulation

scholarly journals Chromosome Instability, Aging and Brain Diseases

Cells ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 1256
Author(s):  
Ivan Y. Iourov ◽  
Yuri B. Yurov ◽  
Svetlana G. Vorsanova ◽  
Sergei I. Kutsev
Keyword(s):  
Brain Aging ◽  
Chromosome Instability ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Accelerated Aging ◽  
Brain Diseases ◽  
Aging Brain ◽  
Ontogenetic Changes ◽  
Health And Disease

Chromosome instability (CIN) has been repeatedly associated with aging and progeroid phenotypes. Moreover, brain-specific CIN seems to be an important element of pathogenic cascades leading to neurodegeneration in late adulthood. Alternatively, CIN and aneuploidy (chromosomal loss/gain) syndromes exhibit accelerated aging phenotypes. Molecularly, cellular senescence, which seems to be mediated by CIN and aneuploidy, is likely to contribute to brain aging in health and disease. However, there is no consensus about the occurrence of CIN in the aging brain. As a result, the role of CIN/somatic aneuploidy in normal and pathological brain aging is a matter of debate. Still, taking into account the effects of CIN on cellular homeostasis, the possibility of involvement in brain aging is highly likely. More importantly, the CIN contribution to neuronal cell death may be responsible for neurodegeneration and the aging-related deterioration of the brain. The loss of CIN-affected neurons probably underlies the contradiction between reports addressing ontogenetic changes of karyotypes within the aged brain. In future studies, the combination of single-cell visualization and whole-genome techniques with systems biology methods would certainly define the intrinsic role of CIN in the aging of the normal and diseased brain.

The Role of B Group Vitamins and Choline in Cognition and Brain Aging

2017 ◽  
pp. 139-158 ◽  
Author(s):  
Francesco Bonetti ◽  
Gloria Brombo ◽  
Giovanni Zuliani
Keyword(s):  
Brain Aging

scholarly journals Differential role of melatonin in healthy brain aging: a systematic review and meta-analysis of the SAMP8 model

Aging ◽  
2021 ◽  
Author(s):  
Dewan Md. Sumsuzzman ◽  
Zeeshan Ahmad Khan ◽  
Jeonghyun Choi ◽  
Yonggeun Hong
Keyword(s):  
Systematic Review ◽  
Brain Aging ◽  
Meta Analysis

scholarly journals The protective and toxic role of neuromelanins in brain aging and Parkinson’s disease

SpringerPlus ◽  
2015 ◽  
Vol 4 (S1) ◽  
Author(s):  
Luigi Zecca ◽  
Chiara Bellei ◽  
Pierluigi Mauri ◽  
Luigi Casella ◽  
Carolina Cebrián ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Brain Aging
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