Ticlopidine prophylaxis reduces the risk of a major vascular event

InPharma ◽  
1989 ◽  
Vol 691 (1) ◽  
pp. 7-7
Keyword(s):  
Vascular Event ◽  
Major Vascular Event

scholarly journals Review on Effects of NSAID`S on Different Systems

2020 ◽  
Vol 8 (1) ◽  
pp. 100-109
Author(s):  
Naresh Puppala ◽  
Gantala Alekhya Reddy
Keyword(s):  
Side Effects ◽  
Adverse Effects ◽  
Sodium Excretion ◽  
Vascular Event ◽  
Over The Counter ◽  
Inflammatory Drugs ◽  
Major Vascular Event ◽  
Anti Inflammatory

Non steroidal anti-inflammatory drugs (NSAIDs) are amongst the most commonly prescribed medication. Some are available over the counter and likely to be abused. The gastrointestinal (GI), renal and cardiovascular (CV) side effects limit NSAIDs use. These side effects occurred at a rate as low as 1%–5% for NSAID users. The gastrointestinal (GI), renal and cardiovascular (CV) side effects limit NSAIDs use. Some studies  have shown  that an extra 2to8 per 1000 people per year may have a major vascular event from using an NSAID. Several studies demonstrated that conventional NSAIDs were associated with a higher risk of AKI and GN and decreased kidney hemodynamic functions, including sodium excretion. NSAIDs have a range of adverse effects mainly affecting the GI, renal and CV systems.  

Abstract TP397: Clinical And Functional Outcome Of Adult Patients Diagnosed With Moyamoya Disease In Childhood

Stroke ◽  
2017 ◽  
Vol 48 (suppl_1) ◽  
Author(s):  
David Fam ◽  
Nomazulu Dlamini ◽  
Cheryl Jaigobin
Keyword(s):  
Ischemic Stroke ◽  
North America ◽  
Natural History ◽  
Functional Outcome ◽  
Moyamoya Disease ◽  
Vascular Event ◽  
Moyamoya Syndrome ◽  
The Mean

Background: Moyamoya disease is a progressive occlusive arteriopathy of the terminal ICA and its branches, leading to the formation of unstable collateral vessels. The disease is found worldwide, and is associated with a number of predisposing conditions, termed moyamoya syndrome. Currently there is a paucity of data on the natural history of moyamoya disease in North America, especially the long-term outcome of pediatric moyamoya. Objective: Our objectives were to determine the rate of recurrent TIA, ischemic stroke and intracerebral hemorrhage in patients presenting with pediatric Moyamoya disease and to assess long-term functional outcome. Methods: This study was a retrospective chart review of 52 patients presenting with pediatric moyamoya disease. We included patients aged 18 or older with a diagnosis of moyamoya disease or syndrome. All patients had confirmatory baseline vascular imaging (MRA or CTA +/- cerebral angiography). Baseline demographic variables and annual vascular event recurrence risk were obtained from the records. Modified Rankin Score (MRS) at presentation and last follow-up were determined from clinical records. Results: Of the original cohort, 34 patients were included for analysis. The mean age of the patients was 23.9 years. The mean age at presentation was 9 years (SD=4) with an average follow-up of 11.3 years (SD=5.1) for a total of 383 patient years. There was slight female predominance (1.4:1). Fifty percent of patients (17) presented with ischemic stroke. A total of 26 patients (76%) underwent surgery, with 7 (21%) requiring repeat surgery. The annual vascular recurrent event rate was 5.0% (19/383), which was not significantly different between surgical and non-surgical groups or between different moyamoya syndrome subtypes. Most of the recurrent events were TIA (annual recurrence 3.7%). There was no significant difference between initial MRS, MRS at last follow-up and mean change in MRS between surgical and non-surgical groups. Conclusion: Our study is the largest North American natural history study of pediatric moyamoya. Our observations indicate that pediatric moyamoya in North America have low recurrent vascular event rates and long-term functional outcomes are good, even in conservatively managed patients.

Abstract W P371: Periodontal Disease is Associated with Aortic Arch Atheroma a Marker of Recurrent Vascular Events in Stroke/TIA Patients

Stroke ◽  
2015 ◽  
Vol 46 (suppl_1) ◽  
Author(s):  
Matthew Chung ◽  
Alan Hinderliter ◽  
Steven Offenbacher ◽  
James Beck ◽  
Souvik Sen
Keyword(s):  
Risk Factor ◽  
Periodontal Disease ◽  
Aortic Arch ◽  
Vascular Event ◽  
Stroke Work ◽  
Transesophageal Echocardiogram ◽  
Vascular Events ◽  
Clinical Measures ◽  
Prospective Longitudinal ◽  
Work Up

Background: Periodontal disease (PD) is independently associated with recurrent vascular events in Stroke/TIA. Aortic arch atheroma (AA) is an independent risk factor for stroke. The association between PD and AA has not been described. Objective: To test the association between: 1) significant AA and recurrent vascular event in stroke/TIA 2) PD and AA (plaque severity and characteristics) Methods: In this prospective longitudinal hospital-based cohort study, PD was assessed in Stroke/TIA patients. Based on clinical measures patients were classified to have high (HPD) versus low periodontal disease (LPD). As part of their stroke work-up, AA was assessed using transesophageal echocardiogram (TEE). Based on plaque thickness the AA was graded as mild (0-0.99 mm), moderate (1-3.99 mm) or severe (≥4 mm), as well as plaque characteristics, namely mobility, ulceration and calcification. The patients were followed up for recurrent vascular events, namely stroke, TIA, myocardial infarction and vascular death. Results: In an eighteen-month period, 106 patients were evaluated, 40(38%) showed HPD and 27 (26%) had recurrent vascular events over a median of 24 months (range 12-24 months). AA assessed by TEE revealed 16 with mild, 73 with moderate, and 17 with severe plaque. Those with severe AA had a higher rate of recurrent vascular event compared to those without (Figure). Severe AA was associated with recurrent vascular events (HR 2.3, 95% CI, 1.02-5.32). HPD patients had higher (p = 0.004) AA plaque thickness (Mean±SD 2.0±2.4 mm) compared with LPD (1.6±1.2 mm). HPD was associated with moderate AA (OR 10.5, 95% CI, 1.3-84) and severe AA (OR 16.9, 95% CI, 1.8-158). Among plaque characteristics HPD was associated (p=0.02) with calcification. Conclusion: In stroke/TIA patients severe AA is associated with recurrent vascular events. HPD is associated with an increased AA plaque thickness and calcification. The results suggest that PD may be a risk factor for AA.

Abstract 2872: Interleukin-18/interleukin-10 Ratio is an Independent Predictor of Cardiovascular Events in Patients with Stable Coronary Artery Disease

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Paulo V Camargo ◽  
Raquel M Roman ◽  
Ana Paula W Rossini ◽  
Anderson Dedonelli ◽  
Steffan F Stella ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Inflammatory Cytokine ◽  
Stable Coronary Artery Disease ◽  
Vascular Event ◽  
Coronary Syndrome ◽  
Anti Inflammatory ◽  
Hs Crp ◽  
Artery Disease ◽  
Stable Cad

Background: The balance between pro-inflammatory cytokine IL-18 and anti-inflammatory cytokine IL-10 has been suggested to play a role in atherogenesis and in the prognosis of acute coronary syndrome (ACS). We hypothesized that stable coronary artery disease (CAD) patients have a pro-inflammatory profile prior to an acute event. Methods : A case-control study nested in a cohort of stable CAD patients was performed. Patients were consecutively included and blood samples collected at 3-months intervals. Cases were patients who presented any vascular event (death, ACS, ischemic stroke, peripheral arterial occlusion and revascularization) and controls were retrieved from a sequential list, in a 1:2 ratio, after 22 ± 9 months of follow-up. Serum hs-CRP, interleukin (IL)-10, IL-18 were measured in two serial samples, collected before the events. Results : Among 176 CAD patients, 42 developed a vascular event (cases) and 76 were selected to the control group. Serum levels of IL-18 were significantly higher among cases (411 ± 185 vs. 340 ± 133pg/ml; p = 0.037). Hs-CRP levels (5.4 vs. 5.1mg/l), IL-10 (7.4 vs. 7.2pg/ml), and IL-18/IL-10 ratio (66 vs. 61) were not different between cases and controls in both samples. Cox regression analysis showed that IL-18 levels (HR 1.75 (0.89 –3.5;p = 0.11) and IL-18/IL-10 ratio (HR 1.97; 1.0 –3.8) were predictors of worse prognosis (Figure ). Conclusion: In this study, IL-18 and IL-18/IL-10 ratio were associated with clinical outcomes and support the hypothesis that the balance between pro-inflammatory and anti-inflammatory cytokines may be an important determinant of vascular events in stable CAD patients.

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