Cisapride improves colonic transit in patients with colonic inertia

InPharma ◽  
1989 ◽  
Vol 709 (1) ◽  
pp. 8-8
Keyword(s):  
Colonic Transit ◽  
Colonic Inertia

Electrical Therapy May Speed Slow Colonic Transit

2006 ◽  
Vol 36 (21) ◽  
pp. 43
Author(s):  
AMY ROTHMAN SCHONFELD
Keyword(s):  
Colonic Transit ◽  
Electrical Therapy

Luojia Score: A New Quantitative Option for Evaluating Precise Colonic Transit and Symptom Severity of Constipation

2020 ◽  
Author(s):  
Kongliang Sun ◽  
Qun Qian ◽  
Jinxiang Hu ◽  
Weicheng Liu ◽  
Yuntian Hong ◽  
...  
Keyword(s):  
Symptom Severity ◽  
Colonic Transit

Mo1570 THE INTESTINAL MICROBIOTA FROM A PATIENT WITH IBS-C SLOWS MOUSE COLONIC TRANSIT BY DISRUPTING INTERSTITIAL CELL OF CAJAL NETWORK

2020 ◽  
Vol 158 (6) ◽  
pp. S-899-S-900
Author(s):  
Xiaopeng Bai ◽  
Giada De Palma ◽  
Premysl Bercik ◽  
Jun Lu ◽  
Stephen M. Collins
Keyword(s):  
Intestinal Microbiota ◽  
Interstitial Cell ◽  
Colonic Transit ◽  
Interstitial Cell Of Cajal

Luminally released serotonin stimulates colonic motility and accelerates colonic transit in rats

2007 ◽  
Vol 293 (1) ◽  
pp. R64-R69 ◽  
Author(s):  
Kiyoshi Tsukamoto ◽  
Hajime Ariga ◽  
Chris Mantyh ◽  
Theodore N. Pappas ◽  
Hidenori Yanagi ◽  
...  
Keyword(s):  
Ex Vivo ◽  
Colonic Motility ◽  
Physiological Role ◽  
Distal Colon ◽  
Proximal Colon ◽  
Colonic Transit ◽  
Intraluminal Pressure ◽  
Ex Vivo Model ◽  
Colon Tissue ◽  
Ec Cells

Enterochromaffin (EC) cells of the epithelial cells release 5-HT into the lumen, as well as basolateral border. However, the physiological role of released 5-HT into the lumen is poorly understood. Concentrations of 5-HT in the colonic mucosa, colonic lumen, and feces were measured by HPLC in rats. To investigate whether intraluminal 5-HT accelerates colonic transit, 5-HT and 51Cr were administered into the lumen of the proximal colon, and colonic transit was measured. To investigate whether 5-HT is released into the lumen, we used an ex vivo model of isolated vascularly and luminally perfused rat proximal colon. To investigate whether luminal 5-HT is involved in regulating stress-induced colonic motility, the distal colonic motility was recorded under the stress loading, and a 5-HT3 receptor antagonist (ondansetron, 10−6 M, 0.5 ml) was administered intraluminally of the distal colon. Tissue content of 5-HT in the proximal colon (15.2 ± 4.3 ng/mg wet tissue) was significantly higher than that in the distal colon (3.3 ± 0.7 ng/mg wet tissue), while fecal content and luminal concentration of 5-HT was almost the same between the proximal and distal colon. Luminal administration of 5-HT (10−6–10−5 M) significantly accelerated colonic transit. Elevation of intraluminal pressure by 10 cmH2O significantly increased the luminal concentration of 5-HT but not the vascular concentration of 5-HT. Stress-induced stimulation of the distal colonic motility was significantly attenuated by the luminal administration of ondansetron. These results suggest that luminally released 5-HT from EC cells plays an important role in regulating colonic motility in rats.

Functional cine MRI for the assessment of the colonic transit time—a pilot study

2005 ◽  
Vol 1281 ◽  
pp. 1319
Author(s):  
Ch. Kirchhoff ◽  
S. Buhmann ◽  
Ch. Wielage ◽  
K. Hallfeldt ◽  
A. Lienemann ◽  
...  
Keyword(s):  
Pilot Study ◽  
Transit Time ◽  
Colonic Transit ◽  
Colonic Transit Time ◽  
Cine Mri
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