KEEPING AN EYE ON THE SIDE EFFECTS OF ANTIGLAUCOMA EYE DROPS

InPharma ◽  
1981 ◽  
Vol 279 (1) ◽  
pp. 7-7
Keyword(s):  
Side Effects ◽  
Eye Drops

Managing Side Effects on Ocular Surface Caused by Glaucoma Eye Drops

2019 ◽  
Vol 26 (22) ◽  
pp. 4223-4224 ◽  
Author(s):  
Antonio Ferreras ◽  
Michele Figus ◽  
Paolo Fogagnolo ◽  
Michele Iester ◽  
Paolo Frezzotti
Keyword(s):  
Side Effects ◽  
Ocular Surface ◽  
Eye Drops

Tropicamide eye drops reduce clozapine-induced hypersalivation: A case report

2016 ◽  
Vol 33 (S1) ◽  
pp. S543-S544 ◽  
Author(s):  
O. Kilic ◽  
H.M. Ozturk ◽  
E. Ata
Keyword(s):  
Case Report ◽  
Side Effects ◽  
Side Effect ◽  
Negative Symptoms ◽  
Rating Scale ◽  
Short Form ◽  
Eye Drops ◽  
Oral Application ◽  
Competing Interest ◽  
Pressure Changes

IntroductionClozapine-induced sialorrhea (CIS) is a common, treatment-limiting and stigmatizing side effect. All systemic agents that are used for hypersalivation may increase clozapine side effects such as blood pressure changes, constipation, or arrythmias. Oral application of topical anti-muscarinic agents may be a low side effect option for treatment of CIS.ObjectiveThe aim of this case report was to propose an off-label treatment of tropicamide drops to CIS and to stimulate further investigation.Case reportA 33-year-old male inpatient with schizophrenia has been on clozapine 800 mg and amisulpride 600 mg/day. His drooling was occasional and severe as drool drips off his chin during the day and night. Wet area over the pillow, visual analog scale (VAS), the short form of health survey (SF-36), UKU side effect rating scale, scale for the assessment of negative symptoms (SANS), scale for the assessment of positive symptoms (SAPS) were applied at baseline and in one-week intervals. Oral application of one drop of tropicamide % 0.5 (5 mg/mL) to left and one drop to right side before going to bed in the first week and two drops to each side were administered subsequently. Informed consent was given by the patient.ResultsNo psychological, neurological, autonomic and other side effects were observed associated with tropicamide. On VAS, the patient rated hypersalivation 5/7 at baseline, 4/7 after one drop each, 3/7 after two drops each.ConclusionsThe reduction of CIS by oral use of tropicamide eye drops is promising and should be explored with randomized controlled trials.Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals Drug-induced mydriasis in infants born at different gestation terms

2018 ◽  
Vol 11 (4) ◽  
pp. 85-92
Author(s):  
Elvira I. Saidasheva ◽  
Svetlana V. Biyanovskaya ◽  
Fedor V. Kovshov ◽  
Marina S. Petrachkova ◽  
Olga S. Dolgova ◽  
...  
Keyword(s):  
Side Effects ◽  
Retinopathy Of Prematurity ◽  
Full Term ◽  
Eye Drops ◽  
Drug Induced ◽  
Term Infants ◽  
Extremely Preterm ◽  
Extremely Preterm Infants ◽  
Term Newborns ◽  
Group 2

Background. At the present time, the problem of choice of eye drops to achieve adequate mydriasis with minimal side effects for retinopathy of prematurity screening remains an urgent challenge. Purpose. To estimate the clinical efficacy of combination mydriatic eye drops Fenicamide in infants born at different gestation terms. Materials and methods. Under observation, there were 75 newborns (150 eyes) and babies aged from 1 day to 3 months (average, 38.2 ± 32.2 days). Patients were distributed into 3 groups depending on gestational age: group 1 consisted of 25 full-term infants; group 2 – of 25 premature babies, and group 3 – of 25 extremely preterm infants. To achieve mydriasis, 1 drop of combination eye drops (5% phenylephrine and 0.8% tropicamide) was instilled. Dynamics of pupil diameter change in each group of patients was registered within 4 hours, and side effects were recorded within 24 hours. The quality of fundus visualization was estimated using a pediatric retinal camera RetCam 3. Results. Maximal pupil dilation (average, 6.5 ± 0.5 mm) was reached to 60 ± 14 min after instillation on average; pupil remained dilated within 1 hour, its diameter became normal in 4 hours. Mydriasis varied from 5.9 mm in extremely premature infants to 7 mm in the full-term newborns (p > 0.05), and allowed a full and high quality examination of the fundus in all patients, including the visualization of peripheral zones of the retina for retinopathy of prematurity screening. It was established that drug side effects were absent in 76% (57) of infants, they were present in 24% (18) of infants, mostly as local reaction. Conclusion. Fenicamide eye drops are an effective mydriatic medication, with a convenient instillation regimen, have minimal side effects, and can be recommended for retinopathy of prematurity screening and monitoring.

Ibopamine Treatment in Chronic Hypotony Secondary to Long-Lasting Uveitis. A Case Report

2000 ◽  
Vol 10 (4) ◽  
pp. 332-334 ◽  
Author(s):  
P. Pivetti-Pezzi ◽  
S. Da Dalt ◽  
M. La Cava ◽  
M. Pinca ◽  
F. De Gregorio ◽  
...  
Keyword(s):  
Visual Acuity ◽  
Intraocular Pressure ◽  
Case Report ◽  
Side Effects ◽  
Visual Field ◽  
Clinical Efficacy ◽  
Eye Drops ◽  
Days Of Therapy ◽  
History Of

Purpose To assess the clinical efficacy of ibopamine eye drops in severe hypotony secondary to chronic progressive uveitis. Methods Case report. A 47-year-old man with a 37-year history of diffuse uveitis and severe refractory hypotony was treated with topical 2% ibopamine (Trazyl®) six times a day. Intraocular pressure, visual acuity, visual field and side effects were recorded during 15 months of follow-up. Results IOP, visual acuity and visual field increased after four days of therapy and lasted for two months when the drug was suspended because of the onset of filamentous keratopathy. A new course of treatment with 2% ibopamine eye drops in a different solvent (BSS®) resulted in a stable increase in IOP, VA and visual field, with no side effects in a follow-up of 13 months. Conclusions Ibopamine 2% eye drops in BSS® solvent seem effective in the treatment of uveitis-related hypotony.

scholarly journals Ocular and systemic side effects of brimonidine 0.2% eye drops (Alphagan®) in children

Eye ◽  
2004 ◽  
Vol 18 (1) ◽  
pp. 24-26 ◽  
Author(s):  
R J C Bowman ◽  
J Cope ◽  
K K Nischal
Keyword(s):  
Side Effects ◽  
Eye Drops ◽  
Systemic Side Effects

scholarly journals Use of eye drops self-medication in Aseer region, Southern Saudi Arabia

2021 ◽  
Vol 19 (2) ◽  
Author(s):  
Abdulrahman Alamri ◽  
Razan Asiri ◽  
Abdulaziz Alnami ◽  
Raneem Hijazi ◽  
Lamya Almobty
Keyword(s):  
Side Effects ◽  
Demographic Data ◽  
Eye Drops ◽  
Cross Sectional Survey ◽  
Self Medication ◽  
Blurred Vision ◽  
Cross Sectional ◽  
Gender And Education ◽  
Social Media Platforms ◽  
Structured Questionnaire

Background: Self-medication is defined as the use of drugs to manage a self-diagnosed disease or complaint, or the intermittent or continued use of a prescribed drug for chronic or recurrent disease or symptoms. Self-medication includes getting medications without a prescription, resubmitting old prescriptions to buy medicines, sharing medicines with relatives or members of one’s social circle, or using leftover medicines stored at home. Risks are related to many factors including not only the possible severe side effects of the drug itself, but also hazardous because of improper treatment. Methodology: A descriptive cross-sectional survey was used targeting all population in Aseer region. The study was conducted during the period from May 2020 to August 2020. Data were collected using structured questionnaire which was developed by the researchers after intensive literature review and expert’s consultation. The questionnaire data included person’s socio-demographic data such as age, gender, and education. The second section of the questionnaire covered eye drops self-medication data. The questionnaire was uploaded online using social media platforms by the researchers and their relatives and friends to be filled in by all population in Aseer region. Results: A total of 209 participants completed the study questionnaire. Participants’ ages ranged from 18 to 65 years old with mean age of 32.9 ± 11.6 years. Exactly 152 (72.7%) participants were females and 158 (75.6%) had educational level of university or more. Regarding persons who advised participants to use eye drops, the most reported was the person themself (34.4%; 72) followed by family and friends (29.2%), and pharmacist (20.6%). As for causes of using unprescribed eye drops, 105 (50.2%) participants used the eye drops for itching in the eye, followed by eye redness (47.4%), eye pain (22.5%). Regarding side effects of used drops, the most reported was excessive lacrimation (5.7%), followed by blurred vision (5.7%), and eye inflammations (4.3%), Conclusions: In conclusion, the study revealed that there is a large portion of Aseer region population practicing self-medicating behavior based on their own concept or advice from friends and family most of the time, without consulting a specialized physician. Key words: Eye drops, self-medication, unprescribed, use, population, causes, practice

scholarly journals 742 Myocarditis after SARS-CoV-2 vaccine: is that so simple?

2021 ◽  
Vol 23 (Supplement_G) ◽  
Author(s):  
Andrea Impellizzeri ◽  
Nicole Suma ◽  
Francesco Palermo ◽  
Angelo Sansonetti ◽  
Matteo Armillotta ◽  
...  
Keyword(s):  
Side Effects ◽  
Current Literature ◽  
Acute Myocarditis ◽  
Interventricular Septum ◽  
Vaccine Dose ◽  
Artery Dissection ◽  
Time Interval ◽  
Eye Drops ◽  
Inferior Wall ◽  
Cardiac Side Effects

Abstract SARS-CoV-2 vaccination is associated with potential side effects, particularly following second vaccine dose. Recent case series have reported a potential association between SARS-CoV-2 vaccination and acute myocarditis, predominantly in young males. We hereby describe a previously healthy 17-year-old man, with no past cardiac history, who presented to the emergency department with persistent chest pain and fever (up to 38 °C). The patient had received the first dose of Cominarty (BioNTech/Pfizer) vaccine 10 days before symptom onset and reported flu-like symptoms and conjunctivitis involving both eyes one week before administration of the first vaccine dose. On that occasion, no COVID test was performed and the patient was treated with anti-inflammatory drugs and antibiotic eye drops. On admission, laboratory tests were performed (Troponin-I Δ 19 500–23 270 ng/l. CRP 23 mg/dl, ESR 43 s, WBC 17 570 cell/mm3) as well as COVID-19 PCR, Serological tests and Autoimmune disorders panel all resulting negative. CT coronary angiogram did not reveal any spontaneous coronary artery dissection or anomalous origin of coronary arteries and Calcium Score was 0. Transthoracic echocardiography showed a depressed LVEF (36%) with concomitant posterior and inferior wall as well as posterior and anterior basal interventricular septum hypokinesia. Endomyocardial biopsy revealed multifocal lymphocytic myocarditis with sub-endomyocardial and interstitial fibrosis. CMR was also performed (1-week after presentation) demonstrating mildly depressed systolic function (LVEF 47%), with hypokinesia of the posterior and inferior wall, increased signal intensity on T2 maps (58 ms, n.v. <55 ms), prolonged native T1 values (1083 ms, n.v. <1030 ms) as well as subepicardial and intramyocardial LGE enhancement of infero-lateral segments reflecting intercellular fibrosis. Thereafter, the patient was discharged with medical therapy including ACE-inhibitor, colchicine, and ibuprofen. Given the close proximity between SARS-CoV-2 vaccine administration and the absence of other predisposing conditions, the aetiology of myocarditis was attributed to the vaccine. In addition, as the patient suffered from flu-like symptoms and conjunctivitis 1 week before the vaccine, a previous paucisymptomatic SARS-CoV-2 infection was suspected and anti-SARS-Coronavirus Nucleocapsid Protein antibody test revealed high antibody levels with low IgG avidity. Given that myocarditic symptoms evolved after complete Sars-Cov2 symptom resolution, our first hypothesis is that the infection is unlikely to be the cause of acute myocarditis in this patient. Indeed, current literature on COVID-related myocarditis reports close temporal association between respiratory symptoms and myocarditis onset. In support to our hypothesis, recent trials have reported that myocarditis more frequently occurs following administration of mRNA vaccines especially in male adolescents and young adults like our patient. However, cardiac side effects typically occur after full vaccination and symptoms appear within three days following the second dose, which does not fully apply to this case. Notwithstanding this, more recent studies have reported myocarditis even after first vaccination dose in patients with previous COVID-19 infection, analogously to the case described. This case suggests a complex interaction between immunological factors and covid infection/vaccination with potential significant implications on the cardiovascular system. From current literature, much uncertainty remains regarding time interval criteria for reliable post-vaccination myocarditis diagnosis, hence large-scale clinical trials are needed to address this issue.

scholarly journals Gel-Based Materials for Ophthalmic Drug Delivery

Gels ◽  
2021 ◽  
Vol 7 (3) ◽  
pp. 130
Author(s):  
Roberta Cassano ◽  
Maria Luisa Di Gioia ◽  
Sonia Trombino
Keyword(s):  
Drug Delivery ◽  
Side Effects ◽  
Contact Lenses ◽  
Prolonged Release ◽  
Eye Drops ◽  
Non Invasive ◽  
Ophthalmic Drug Delivery ◽  
Ophthalmic Drug ◽  
In Situ Gelling

The most common route of administration of ophthalmic drugs is the topical route because it is convenient, non-invasive, and accessible to all patients. Unfortunately, drugs administered topically are not able to reach effective concentrations. Moreover, their bioavailability must be improved to decrease the frequency of administrations and their side effects, and to increase their therapeutic efficiency. For this purpose, in recent decades, particular attention has been given to the possibility of developing prolonged-release forms that are able to increase the precorneal residence time and decrease the loss of the drug due to tearing. Among these forms, gel-based materials have been studied as an ideal delivery system because they are an extremely versatile class with numerous prospective applications in ophthalmology. These materials are used in gel eye drops, in situ gelling formulations, intravitreal injections, and therapeutic contact lenses. This review is intended to describe gel-based materials and their main applications in ophthalmology.

scholarly journals ESTIMATION OF TOLERANCE OF A DOMESTIC NON-STEROID ANTI-INFLAMMATORY DRUG IN THE POSTOPERATIVE PERIOD OF EXTRACTION OF CATARACTS

2021 ◽  
pp. 103-106
Author(s):  
F. Bakhritdinova ◽  
K. I. Narzikulova Kumri Islamovna ◽  
Sh. A. Yusupov ◽  
M. E. Egamberdieva
Keyword(s):  
Side Effects ◽  
Postoperative Period ◽  
Inpatient Treatment ◽  
Cataract Extraction ◽  
Postoperative Treatment ◽  
Study Group ◽  
Eye Drops ◽  
Inflammatory Drug ◽  
Medical Academy ◽  
Anti Inflammatory

Summary. The article discusses the efficacy and tolerability of a non-steroidal anti-inflammatory domestic drug after cataract extraction, the severity of side effects of a non-steroidal anti-inflammatory drug. The aim of the study – optimization of methods of postoperative treatment of cataracts using the domestic non-steroidal anti-inflammatory Diclofenac drug, 0.1 % eye drops, produced by JV “Jurabek Laboratories” LLC. Materials and Methods. The study included patients who were at inpatient treatment at the Clinic No. 2 of the Tashkent Medical Academy. The study group included 60 people: 21 men and 39 women, the age of patients was 18–73 years. In two groups, we compared the efficacy and tolerability of domestic and foreign NSAIDs after cataract extraction. Results. The effectiveness of the complex treatment is confirmed by the reduction in the duration of relief of the main symptoms of inflammation in patients of both groups. Both drugs did not cause side effects and were well tolerated by patients. Tolerability of the treatment in the group receiving domestic NSAIDs was 93.4 %, in the group receiving foreign NSAIDs – 95.7 %. Conclusions. According to the results of our studies, it was proved that therapy after cataract extraction with the use of a domestic-made NSAID is not inferior in efficiency and tolerability to a foreign-made drug and can be used in the postoperative period of cataract.

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