Tenoxicam: faecal blood loss associated with the drug is similar to that occuring with piroxicam therapy

InPharma ◽  
1985 ◽  
Vol 502 (1) ◽  
pp. 6-6
Keyword(s):  
Blood Loss ◽  
Faecal Blood Loss

Studies on Ponstan (Mefenamic Acid): I. Gastro-Intestinal Blood Loss; II. Absorbtion and Excretion of a New Formulation

1975 ◽  
Vol 3 (3) ◽  
pp. 176-182 ◽  
Author(s):  
A R Tali ◽  
S P Mistilis
Keyword(s):  
Blood Loss ◽  
Mefenamic Acid ◽  
Control Level ◽  
Serum Levels ◽  
Intestinal Bleeding ◽  
Level Curves ◽  
Significant Difference ◽  
Coated Tablet ◽  
New Formulation ◽  
Faecal Blood Loss

Using improved techniques in a study of faecal blood loss no significant change over control level occurred during administration of mefenamic acid 500 mg t.i.d. for six days. This lack of gastro-intestinal bleeding is at variance with earlier findings for this compound. Studies of two mefenamic acid formulations (250 mg capsule and 500 mg filmseal tablet) showed no significant difference in area under blood level curves or in urinary output data, indicating equivalent total absorption. The 500 mg film-coated tablet gave significantly higher serum levels at 0·5 hours, whereas the 250 mg capsule gave significantly higher serum levels at 6 and 8 hours.

Occult Faecal Blood Loss Determined by Chemical Tests and a51Cr Method

1981 ◽  
Vol 16 (2) ◽  
pp. 245-252 ◽  
Author(s):  
J. H. Dybdahl ◽  
L. N. W. Daae ◽  
S. Larsen
Keyword(s):  
Blood Loss ◽  
Faecal Blood Loss

Faecal Blood Loss Associated with Aspirin and Pentoxifylline, Given Alone and in Combination

1992 ◽  
Vol 4 (3) ◽  
pp. 215-218 ◽  
Author(s):  
Bernhardt Meyer ◽  
Frank Muller ◽  
Herman Luus ◽  
Thys Lotter
Keyword(s):  
Blood Loss ◽  
Faecal Blood Loss

Blood loss during Nippostrongylus brasiliensis infection in the rat

Parasitology ◽  
1986 ◽  
Vol 93 (3) ◽  
pp. 539-546
Author(s):  
A. G. Cummins ◽  
T. D. Bolin ◽  
V. M. Duncombe ◽  
A. E. Davis
Keyword(s):  
Blood Loss ◽  
Primary Infection ◽  
Worm Burden ◽  
Haemoglobin Concentration ◽  
Initial Study ◽  
Nippostrongylus Brasiliensis ◽  
Worm Count ◽  
Faecal Egg Count ◽  
Hb Concentration ◽  
Faecal Blood Loss

SUMMARYFaecal blood loss was measured during Nippostrongylus brasiliensis infection in the DA rat using 51Cr-labelled red blood cells (r.b.c.s). In an initial study, faecal blood loss was measured on day 7 of primary infection with 3000 larvae administered subcutaneously (s.c), and found to be 0·03 ml/24 h in uninfected animals and 0·14 ml/24 h in infected animals. In a further experiment, blood loss was measured on the day before infection and for 13 days after primary s.c. infection with 5000 larvae. Faecal blood loss was 0·05 ml/24 h or less until day 3, began to rise from day 5, reached a peak of 0·51 ml/24 h on day 8, and fell until day 13. This was closely associated with the rise and fall of the pooled faecal egg count. Direct worm count confirmed a high worm burden on day 7 and expulsion by day 14. The effect of the worm burden on the haemoglobin concentration (Hb) was measured in a further experiment and showed a fall in Hb with a mean worm burden of 726 compared to that of 47 or 284 worms. The study concluded that there is minimal background blood loss in uninfected rats but that infection with N. brasiliensis is a cause of intestinal blood loss and this is associated with a fall in Hb concentration that is dependent on the worm burden.

scholarly journals Quantitative measurement of faecal blood loss: comparison of radioisotopic and chemical analyses.

1991 ◽  
Vol 44 (5) ◽  
pp. 391-394 ◽  
Author(s):  
M B Leahy ◽  
M J Pippard ◽  
M B Salzmann ◽  
M G Rinsler ◽  
R Hesp ◽  
...  
Keyword(s):  
Blood Loss ◽  
Quantitative Measurement ◽  
Chemical Analyses ◽  
Faecal Blood Loss
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