ASTEMIZOLE DOESN’T APPEAR TO AFFECT KINETICS OF INDOCYANINE GREEN

InPharma ◽  
1983 ◽  
Vol 409 (1) ◽  
pp. 15-15
2019 ◽  
Vol 2019 ◽  
pp. 1-13 ◽  
Author(s):  
Chengyue Li ◽  
Xiaochun Xu ◽  
Nathan McMahon ◽  
Omar Alhaj Ibrahim ◽  
Husain A. Sattar ◽  
...  

Purpose. Paired-agent molecular imaging methods, which employ coadministration of an untargeted, “control” imaging agent with a targeted agent to correct for nonspecific uptake, have been demonstrated to detect 200 cancer cells in a mouse model of metastatic breast cancer. This study demonstrates that indocyanine green (ICG), which is approved for human use, is an ideal control agent for future paired-agent studies to facilitate eventual clinical translation. Methods. The kinetics of ICG were compared with a known ideal control imaging agent, IRDye-700DX-labeled antibody in both healthy and metastatic rat popliteal lymph nodes after coadministration, intradermally in the footpad. Results. The kinetics of ICG and antibody-based imaging agent in tumor-free rat lymph nodes demonstrated a strong correlation with each other (r = 0.98, p<0.001) with a measured binding potential of −0.102 ± 0.03 at 20 min postagent injection, while the kinetics of ICG and targeted imaging agent shows significant separation in the metastatic lymph nodes. Conclusion. This study indicated a potential for microscopic sensitivity to cancer spread in sentinel lymph nodes using ICG as a control agent for antibody-based molecular imaging assays.


1965 ◽  
Vol 67 (5) ◽  
pp. 964
Author(s):  
Mervin Silverberg ◽  
Peter Z. Neumann ◽  
Maceo M. Howard ◽  
Carroll M. Leevy

Head & Neck ◽  
2018 ◽  
Vol 41 (4) ◽  
pp. 1032-1038 ◽  
Author(s):  
Yuxin Wang ◽  
Diya Xie ◽  
Ziyang Wang ◽  
Xudong Zhang ◽  
Qian Zhang ◽  
...  

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pp. 2090-2097 ◽  
Author(s):  
Vishal Saxena ◽  
Mostafa Sadoqi ◽  
Jun Shao

2016 ◽  
Vol 134 ◽  
pp. 342-347 ◽  
Author(s):  
F. Di Nezza ◽  
G. Guerra ◽  
C. Costagliola ◽  
L. Zeppa ◽  
L. Ambrosone

1999 ◽  
Vol 25 (9) ◽  
pp. 1365-1370 ◽  
Author(s):  
Ryoko Uchimoto ◽  
Kazuo Niwa ◽  
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Naohisa Kamiyama ◽  
Yoshitaka Mine ◽  
...  

2006 ◽  
Vol 21 (11) ◽  
pp. 1714-1719 ◽  
Author(s):  
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Tatsuya Miyake ◽  
Tomoko Mishiro ◽  
Kohichiro Furuta ◽  
Takane Azumi ◽  
...  

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