GOING TO BED WITH AN INTERMEDIATE-ACTING INSULIN INJECTION

InPharma ◽  
1983 ◽  
Vol 385 (1) ◽  
pp. 14-14
Keyword(s):  
Insulin Injection ◽  
Acting Insulin ◽  
Intermediate Acting Insulin

Hepatic Ultrastructure and Biochemistry Following Insulin Withdrawal

1985 ◽  
Vol 43 ◽  
pp. 564-565
Author(s):  
S.A. Garfield ◽  
M.F. Fellows ◽  
R.R. Cardell
Keyword(s):  
Smooth Endoplasmic Reticulum ◽  
Insulin Injection ◽  
Diabetic Rats ◽  
Biochemical Responses ◽  
Hormonal Manipulation ◽  
Acting Insulin ◽  
Short Acting Insulin ◽  
Insulin Withdrawal ◽  
Intermediate Acting Insulin ◽  
Streptozotocin Diabetic Rats

This study examines the hepatic ultrastructural and biochemical responses following insulin withdrawal from insulin-maintained streptozotocin- diabetic rats. This hormonal manipulation permitted analysis of the hepatocellular events occurring during diabetic onset. Normoglycemia was maintained in the induced diabetic rats for seven days with daily injections of 5 U intermediate acting insulin (NPH-Iletin) per 100 gram body weight. This was followed by treatment for 24 hr with regular short acting insulin at 6 hr intervals (2.5 U/100 gr b.w.).Animals were sacrificed at intervals following the last insulin injection. Plasma was collected for glucose and insulin determinations. Liver samples were prepared for ultrastructural analysis or were collected for Isolation of rough and smooth endoplasmic reticulum fractions (RER, SER). Isolated RER and SER membrane preparations were analyzed for glucose-6-phosphatase (G-6-Pase) activity, as well as for phospholipid, cholesterol, and fatty acid composition.

scholarly journals Intermediate acting insulin given at bedtime: effect on blood glucose concentrations before and after breakfast.

BMJ ◽  
1983 ◽  
Vol 286 (6372) ◽  
pp. 1173-1176 ◽  
Author(s):  
A J Francis ◽  
P D Home ◽  
I Hanning ◽  
K G Alberti ◽  
W M Tunbridge
Keyword(s):  
Blood Glucose ◽  
Acting Insulin ◽  
Before And After ◽  
Intermediate Acting Insulin ◽  
Blood Glucose Concentrations
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