LABETALOL HAS MINIMAL SIDE EFFECTS IN HYPERTENSIVE PATIENTS

InPharma ◽  
1983 ◽  
Vol 382 (1) ◽  
pp. 5-5
Keyword(s):  
Side Effects ◽  
Hypertensive Patients

Results of a National Therapeutic Trial Conducted in 10 000 Hypertensive Patients by 2000 General Practitioners

1978 ◽  
Vol 55 (s4) ◽  
pp. 353s-354s
Author(s):  
A. Jouve ◽  
L. Goldet ◽  
M. Mathieu
Keyword(s):  
Blood Pressure ◽  
Side Effects ◽  
Diastolic Blood Pressure ◽  
General Practitioners ◽  
Antihypertensive Drugs ◽  
Drop Out ◽  
Therapeutic Trial ◽  
Hypertensive Patients ◽  
Supine Diastolic Blood Pressure ◽  
Treatment Groups

1. 10 294 hypertensive patients were treated and followed by 2200 general practitioners under the supervision of 130 cardiologists and nephrologists. 2. The treatment groups, randomly allocated, were designated to use three distinct antihypertensive drugs, administered alone, and combined two-by-two. 3. Some 75% of patients had a supine diastolic blood pressure of less than 95 mmHg after 4 months treatment. 4. A total of 12% of patients had dropped out by 4 months from entry; no clear relationship was established between side effects and drop out.

Quantifying Side-Effects of Beta-Blockers: The Role of Visual Analogue Scales

1987 ◽  
Vol 6 (3) ◽  
pp. 195-201 ◽  
Author(s):  
R.V. Lewis
Keyword(s):  
Side Effects ◽  
Muscle Fatigue ◽  
Beta Blockers ◽  
Hypertensive Patients ◽  
Visual Analogue Scales ◽  
Detailed Explanation ◽  
Nonparametric Statistical Methods ◽  
Nonparametric Statistical ◽  
Analogue Scales

Beta-blockers are often prescribed for patients who are asymptomatic and for whom the benefits of therapy are likely to be small. Side-effects are therefore of great importance. Symptoms such as muscle fatigue and peripheral coldness are commonly associated with treatment with beta-blockers but these subjective phenomena are difficult to detect and quantify so that their prevalence and severity are uncertain. Conventional symptom questionnaires may be relatively insensitive and visual analogue scales (VAS), which permit interval quantification of subjective phenomena, may have some advantages. They appear to be able to detect the presence of tiredness of the legs and peripheral coldness among hypertensive patients taking beta-blockers and are more sensitive than descriptive or 'category' questionnaires. However, some patients find VAS hard to understand and a minority of patients score erratically for all symptoms. A most detailed explanation is of paramount importance. Scores derived from VAS surveys are not normally distributed and should be examined using nonparametric statistical methods; normalising transformations do not improve the sensitivity of the method.

scholarly journals Hydralazine induces Z-DNA conformation in a polynucleotide and elicits anti(Z-DNA) antibodies in treated patients

1993 ◽  
Vol 294 (2) ◽  
pp. 419-425 ◽  
Author(s):  
T J Thomas ◽  
J R Seibold ◽  
L E Adams ◽  
E V Hess
Keyword(s):  
Side Effects ◽  
Antibody Production ◽  
Dna Conformation ◽  
Hypertensive Patients ◽  
Supercoiled Form ◽  
Gel Retardation Assay ◽  
High Incidence ◽  
Dna Antibodies ◽  
Z Dna ◽  
Normal Controls

We studied the effect of hydralazine, an antihypertensive drug with lupus-inducing side effects, on the conformation of poly(dG-m5dC).poly(dG-m5dC) and a plasmid with a 23 bp insert of (dG-dC)n.(dG-dC)n sequences. Using an e.l.i.s.a. with a monoclonal anti-(Z-DNA) antibody Z22, we found that hydralazine provoked the Z-DNA conformation in poly(dG-m5dC).poly(dG-m5dC) at 250-500 microM concentration. The supercoiled form of hydralazine-treated plasmid bound to Z22 in a gel-retardation assay. To examine further whether Z-DNA could act as an inciting agent in anti-nuclear antibody production in patients, we analysed 65 sera from 25 hypertensive patients taking hydralazine and found anti-(Z-DNA) antibodies in 82% of these sera. Sera from age-matched normal controls showed no binding to Z-DNA. Data on sera drawn sequentially from four hypertensive patients showed that antibodies were present after the drug treatment. These data demonstrate the presence of a high incidence of anti-(Z-DNA) antibodies in patients treated with hydralazine and suggest that a possible mechanism for the production of autoantibodies in drug-related lupus might involve the induction and stabilization of Z-DNA by drugs.

Advantages of Treatment of Hypertension with Minoxidil

1980 ◽  
Vol 25 (2) ◽  
pp. 99-103
Author(s):  
C. Isles ◽  
R. W. Strachan
Keyword(s):  
Blood Pressure ◽  
Side Effects ◽  
Once Daily ◽  
Hypertensive Patients ◽  
Treatment Of Hypertension ◽  
Highly Effective ◽  
Drug Regimens ◽  
Excellent Control

A detailed study has been made of the five hypertensive patients who received Minoxidil in Dumfries; four have been observed for over a year. Minoxidil was found to be highly effective, free from commonly encountered side effects and capable of achieving excellent control of blood pressure when given once daily. Its use led to simpler drug regimens, improved compliance and significant reduction in the length, or even need, of admission to hospital. A prolonged and clinically useful delay in the recurrence of hypertension following withdrawal of the drug was also observed.

Oxprenolol in Hypertension: A Report on 187 Patients in General Practice Originally Treated with Clonidine

1975 ◽  
Vol 3 (6) ◽  
pp. 395-398 ◽  
Author(s):  
W A Forrest
Keyword(s):  
Blood Pressure ◽  
General Practice ◽  
Side Effects ◽  
Receptor Antagonist ◽  
Systolic Pressure ◽  
Hypertensive Patients ◽  
Β Receptor

Substitution, in part or totally, of the β- receptor antagonist, oxprenolol, for clonidine in 187 hypertensive patients resulted in significant reduction in blood pressure levels, particularly of systolic pressure. The incidence of unwanted side-effects was markedly reduced, with an accompanying improvement in the quality of the patient's life.

Clinical and Haemodynamic Study of Minoxidil in Moderately Hypertensive Patients

1976 ◽  
Vol 51 (s3) ◽  
pp. 591s-592s
Author(s):  
H. Ærenlund Jensen ◽  
K. Rasmussen ◽  
N. Mosbæk
Keyword(s):  
Blood Pressure ◽  
Body Weight ◽  
Side Effects ◽  
Hair Growth ◽  
The Other ◽  
Cardiac Insufficiency ◽  
Hypertensive Patients ◽  
Facial Hair ◽  
Blood Tests ◽  
Male Patients

1. We have evaluated the effectiveness and safety of minoxidil in moderately hypertensive out-patients. Eight patients were treated with hydrochlorothiazide and minoxidil for 5 months. The only female patient developed slight, reversible facial hair growth. In the other seven patients there was a moderate decrease in blood pressure. There were only minimal side-effects. Mild exertional tachycardia and a mean increase in body weight of 0·5 kg was found, but no oedema or signs of cardiac insufficiency were observed. No abnormalities were seen during routine blood tests. 2. This study shows that minoxidil combined with a diuretic may be successfully used in treating moderately hypertensive male patients.

scholarly journals Direct renin inhibitor in the treatment of paroxysmal atrial fibrillation

2010 ◽  
Vol 16 (1) ◽  
pp. 74-81 ◽  
Author(s):  
B. A. Tatarsky ◽  
N. V. Kazyonova ◽  
N. V. Serebryakov
Keyword(s):  
Atrial Fibrillation ◽  
Risk Factor ◽  
Side Effects ◽  
High Risk ◽  
Heart Rhythm ◽  
Renin Inhibitor ◽  
Hypertensive Patients ◽  
Direct Renin Inhibitor ◽  
Established Risk Factor ◽  
Limited Effectiveness

Atrial fi brillation is the most common heart rhythm disturbance. Hypertension is a well-established risk factor for many cases of atrial fi brillation, but its predictors are still unknown. The available treatment approaches for atrial fi brillation management are characterized by limited effectiveness and high risk of side effects, thus encouraging researches for new studies. Better understanding of the mechanisms leads to the development of new therapy approaches. This paper presents the results of the study of atrial fi brillation prevention in hypertensive patients getting direct renin inhibitor.

Methyldopa-Induced Hemolytic Anemia and Parkinsonism

1981 ◽  
Vol 15 (6) ◽  
pp. 488-490
Author(s):  
Olu A. Olusanya
Keyword(s):  
Side Effects ◽  
Hemolytic Anemia ◽  
Single Patient ◽  
Hypertensive Patients ◽  
Extrapyramidal Signs

Alpha-methyldopa has been known to cause Coombs positive hemolytic anemia and extrapyramidal signs in hypertensive patients. The occurrence of these side effects has been described separately in patients. This report documents the occurrence of both reactions in a single patient.

Sign in / Sign up

Export Citation Format

Share Document