ANAPHYLACTOID REACTION TO A SMALL DOSE OF d-TUBOCURARINE

InPharma ◽  
1979 ◽  
Vol 212 (1) ◽  
pp. 7-7
1957 ◽  
Vol 35 (1) ◽  
pp. 251-256 ◽  
Author(s):  
V. W. Adamkiewicz ◽  
Y. Langlois

A single subcutaneous injection of crystalline insulin (20 units) sensitizes considerably the rats to the dextran "anaphylactoid" reaction. This is a type of acute serous inflammation. Insulin precipitates the reaction after a very small dose of dextran (0.05–0.01 ml., 6% solution) has been injected into a "shock organ". Without insulin, such small doses of dextran are quite ineffective. Insulin also precipitates the reaction when dextran (1.0 ml., 6% solution) is injected peripherally on the back. In this site and at this dose, it rarely produces the reaction in normal rats. The sensitization manifests itself despite a cortisone pretreatment.


1957 ◽  
Vol 35 (4) ◽  
pp. 251-256 ◽  
Author(s):  
V. W. Adamkiewicz ◽  
Y. Langlois

A single subcutaneous injection of crystalline insulin (20 units) sensitizes considerably the rats to the dextran "anaphylactoid" reaction. This is a type of acute serous inflammation. Insulin precipitates the reaction after a very small dose of dextran (0.05–0.01 ml., 6% solution) has been injected into a "shock organ". Without insulin, such small doses of dextran are quite ineffective. Insulin also precipitates the reaction when dextran (1.0 ml., 6% solution) is injected peripherally on the back. In this site and at this dose, it rarely produces the reaction in normal rats. The sensitization manifests itself despite a cortisone pretreatment.


2018 ◽  
Vol 1 (1) ◽  
pp. 01-02

In 1969, Mutsuyuki Kochi [1, 2] developed 4-Hydroxybenzaldehyde for use as a novel anti-tumor agent without side effect and patent it. Accordingly, this medicine is capable of preventing carcinogenesis when used in sufficient quantity. To treat advanced cancers, an oncologist should start with giving the cancer patient a small dose of 4-Hydroxybenzaldehyde to avoid the possible severe hemorrhage of a tumor caused by excessive necrosis. Therefore, it has useful applications in treating lymphomas and leukemias. Consequently, those who have these diseases can receive a considerably large dose of the medicine.


1977 ◽  
Author(s):  
J.G. Sharnoff

From 1960 through 1975, 337 patients with surgically treated acute fracture of the hip received subcutaneously administered aqueous heparin sodium to prevent thromboembolic episodes. Four hundred and three patients received no heparin. Their incidence of fatal pulmonary embolism was 3.5 percent. Ninety-five patients receiving the original “small dose” heparin regimen from August 1960 to November 1967 had a 4.2 percent incidence of fatal thromboembolism. These had been administered heparin 8-10 hours or less before surgery. Beginning November 1967 the “small dose” heparin schedule was altered in hip fracture patients to start heparin prophylaxis immediately following hospital admission. One hundred and forty-seven patients treated with the latter schedule had 0.0 percent fatal thromboembolism with the dose modified according to a coagulation time test. The patients received 2,500 units on admission and every 6 hours until the day before operation. Then they were given 5,000 to 10,000 units. 8 to 10 hours before surgery and 2,500 units every 6 hours after surgery until they were fully mobilized. The altered “small dose” heparin regimen adequately monitored by the blood coagulation test, the Dale and Laidlaw Coagulometer, proved highly effective as measured by fatality rates.


2007 ◽  
Vol 98 (1) ◽  
pp. 89-91 ◽  
Author(s):  
Michelle M. Bottenberg ◽  
Geoffrey C. Wall ◽  
Greg A. Hicklin

2003 ◽  
pp. 56-61 ◽  
Author(s):  
Yaakov Beilin ◽  
Jeffrey Zahn ◽  
Sharon Abramovitz ◽  
Howard H. Bernstein ◽  
Sabera Hossain ◽  
...  
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