Omeprazole: 30mg daily may be the minimum dose necessary to produce ulcer healing rates similar to those of H2-antagonists

InPharma ◽  
1986 ◽  
Vol 551 (1) ◽  
pp. 6-6
Keyword(s):  
Ulcer Healing ◽  
H2 Antagonists ◽  
Minimum Dose ◽  
30Mg Daily

Gastric ulcer healing is regulated by platelets through endostatin release: Modulation by ticlopidine, aspirin and celecoxib

2001 ◽  
Vol 120 (5) ◽  
pp. A143-A143
Author(s):  
L MA ◽  
S ELLIOTT ◽  
G CIRINO ◽  
A BURET ◽  
J WALLACE
Keyword(s):  
Gastric Ulcer ◽  
Ulcer Healing ◽  
Gastric Ulcer Healing

Aspirin Did Not Slow Ulcer Healing in PPI Users

2011 ◽  
Vol 41 (11) ◽  
pp. 9
Author(s):  
PATRICE WENDLING
Keyword(s):  
Ulcer Healing

Description of venous leg ulcer healing mechanism

Leczenie Ran ◽  
2015 ◽  
Vol 12 (2) ◽  
pp. 49-58
Author(s):  
Wojciech Twardokęs ◽  
Agata Kołodziej ◽  
Andrzej Ślęzak
Keyword(s):  
Ulcer Healing ◽  
Leg Ulcer ◽  
Venous Leg Ulcer

High voltage pulsed current in pressure ulcer healing: results of a randomized, controlled trial – preliminary study

Leczenie Ran ◽  
2013 ◽  
Vol 10 (1) ◽  
pp. 13-22 ◽  
Author(s):  
Anna Polak ◽  
Anna Walczak ◽  
Jakub Taradaj ◽  
Marzena Dzikiewicz ◽  
Aldona Augustak ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Pressure Ulcer ◽  
High Voltage ◽  
Ulcer Healing ◽  
Controlled Trial ◽  
Pulsed Current ◽  
Randomized Controlled ◽  
Preliminary Study

Efficacy of An Aqueous Morinda citrifolia Fruit Extract-Phytosome Gel in Treating Oral Inflammatory Ulcer in Rabbit Model

2020 ◽  
Vol 21 (15) ◽  
pp. 1699-1710
Author(s):  
Sonsawan Kongpuckdee ◽  
Suwipa Ungphaiboon ◽  
Supreedee Sungkharak ◽  
Narubodee Phadoongsombut ◽  
Sirima Mahattanadul
Keyword(s):  
Ulcer Healing ◽  
Healing Process ◽  
Rabbit Model ◽  
Oral Ulcer ◽  
Poloxamer 407 ◽  
Gelling Agent ◽  
Total Phenolic ◽  
Fruit Extract ◽  
Topical Gel ◽  
Daily Application

Background: Oral inflammatory ulcers are one of the common complaints of patients attending out-patient clinics. Previous in vivo studies had shown that an Aqueous M. citrifolia Fruit Extract (AMFE) possessed anti-inflammatory and ulcer healing activities. Therefore, a standardized topical bioadhesive gel containing AMFE-phytosome was developed and determined for its oral ulcer healing efficacy in a rabbit model. Methods: The AMFE phytosome (AMFE-P) was prepared by a complexation method with the required amount of AMFE: Phosphatidylcholine: Tween 80 to weigh ratio of 2:1:0.2. Poloxamer 407 was used as a gelling agent. The oral ulcer was induced in male New Zealand white rabbits by topical application of acetic acid. Each test compound was applied to the ulcer for 10 days beginning on the second day after the ulcer induction. Complete ulcer healing on the specimen obtained on day 12 was observed histologically using the histological scoring protocol. Results: The optimized gel containing AMFE-P equivalent to AMFE 10%w/w (10%AMFE-P gel) showed the best bioadhesive gel quality, a smooth and homogeneous texture with an optimum viscosity and pH range used in human oral cavity, a good physical and chemical stability and the highest percentage cumulative release of total phenolic and scopoletin content. It was found that a daily application of 10% AMFE-P gel exerted a superior ulcer healing efficacy and a significantly rapid ulcer healing process than a twice daily application of topical gel containing AMFE 10%w/w or chlorhexidine 0.2%. Conclusion: These findings demonstrated that 10% AMFE-P gel has potential as a safe and effective alternative therapeutic agent for oral ulcers.

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