Zinc-E-acetamide Caproate: Similar Peptic Ulcer Healing Rate to Cimetidine

InPharma ◽  
1986 ◽  
Vol 532 (1) ◽  
pp. 12-12
Keyword(s):  
Peptic Ulcer ◽  
Ulcer Healing ◽  
Healing Rate ◽  
Ulcer Healing Rate

scholarly journals Effect of Laser Irradiation at Different Wavelengths (940, 808, and 658 nm) on Pressure Ulcer Healing: Results from a Clinical Study

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
J. Taradaj ◽  
T. Halski ◽  
M. Kucharzewski ◽  
T. Urbanek ◽  
U. Halska ◽  
...  
Keyword(s):  
Laser Therapy ◽  
Ulcer Healing ◽  
Healing Rate ◽  
Pressure Ulcers ◽  
Maximum Output Power ◽  
Maximum Output ◽  
Average Dose ◽  
Radiation Emission ◽  
Group I ◽  
Ulcer Healing Rate

The aim of the study was to assess the efficacy of laser therapy (at different wavelengths: 940, 808, and 658 nm) for treating pressure ulcers. The primary endpoint in this trial included both the percentage reduction of the ulcer surface area and the percentage of completely healed wounds after one month of therapy (ulcer healing rate). The secondary endpoint was the ulcer healing rate at the follow-up evaluation (3 months after the end of the study). In total, 72 patients with stage II and III pressure ulcers received laser therapy once daily, 5 times per week for 1 month using a (GaAlAs) diode laser with a maximum output power of 50 mW and continuous radiation emission. Three separate wavelengths were used for the laser treatment: 940 nm (group I), 808 nm (group II), and 658 nm (group III). An average dose of 4 J/cm2was applied. In group IV, a placebo was applied (laser device was turned off). The laser therapy at a wavelength of 658 nm appeared to be effective at healing pressure ulcers. The wavelengths of 808 and 940 nm did not have any effect in our study.

Ankle Motility is a Risk Factor for Healing of Chronic Venous Leg Ulcers

2001 ◽  
Vol 16 (1) ◽  
pp. 38-40 ◽  
Author(s):  
J. R. Barwell ◽  
M. Taylor ◽  
J. Deacon ◽  
C. Davies ◽  
M. R. Whyman ◽  
...  
Keyword(s):  
Risk Factor ◽  
Pump Power ◽  
Ulcer Healing ◽  
Independent Risk Factor ◽  
Healing Rate ◽  
Leg Ulcer ◽  
Venous Leg Ulcer ◽  
Compression Bandaging ◽  
Venous Ulcers ◽  
Ulcer Healing Rate

Objective: To investigate the effect of ankle motility on chronic venous leg ulcer healing, and to relate this to calf pump function and muscle bulk. Methods: This was a prospective cohort study undertaken in a leg ulcer clinic. Ankle motility, calf-ankle circumference ratio and calf pump power (derived from digital photoplethysmography) were assessed as to their effect on ulcer healing rate. Thirty consecutive patients undergoing multi-layer compression bandaging for open chronic venous ulcers were included. Results: Ankle motility was an independent risk factor for ulcer healing ( p = 0.001, hazard ratio 1.08, 95% CI 1.03–1.13). Ankle motility correlated with calf-ankle circumference ratio ( r = 0.48, p<0.01). No relationship was found between photoplethysmography-derived calf pump power, ankle motility or ulcer healing rate. Conclusions Ulcers in legs with poor ankle motility are slower to heal and this may be related to reduced calf muscle bulk. Ankle exercises or physiotherapy could be considered in such patients.

EFFECT OF SUPPORT SURFACE ON PRESSURE ULCER HEALING RATE*

2004 ◽  
Vol 31 (Supplement) ◽  
pp. S2
Author(s):  
Rachel Ochs ◽  
Susan Horn ◽  
Randall Smout ◽  
Lia van Rijswijk
Keyword(s):  
Pressure Ulcer ◽  
Ulcer Healing ◽  
Healing Rate ◽  
Support Surface ◽  
Ulcer Healing Rate ◽  
Effect Of Support

EMR-Induced Ulcer Healing Rate According to the Duration of Omeprazole Therapy

2004 ◽  
Vol 59 (5) ◽  
pp. P153
Author(s):  
Sun-Young Lee ◽  
Jae J. Kim ◽  
Jun Haeng Lee ◽  
Young-Ho Kim ◽  
Poong-Lyul Rhee ◽  
...  
Keyword(s):  
Ulcer Healing ◽  
Healing Rate ◽  
Ulcer Healing Rate

scholarly journals Recurrence of Acute Duodenal Ulcer

1994 ◽  
Vol 8 (1) ◽  
pp. 21-26
Author(s):  
RJ Bailey ◽  
IG Morrison-Cleator ◽  
A Farley ◽  
A Archambault ◽  
M Oravec ◽  
...  
Keyword(s):  
Ulcer Healing ◽  
Healing Rate ◽  
Multicentre Trial ◽  
Epigastric Pain ◽  
Symptomatic Relief ◽  
Ulcer Recurrence ◽  
Double Blind ◽  
Duodenal Ulcers ◽  
Treatment Groups ◽  
Ulcer Healing Rate

Nizatidine, 300 mg once nightly, was compared with cimetidine, 800 mg once nightly, for treatment of 212 adult out-patients with acute duodenal ulcers in an eight-week randomized, double-blind, multicentre trial. Patients were endoscoped at weeks 2, 4 and 8, regardless of ulcer healing status. No significant differences in ulcer healing rates between treatment groups were seen at weeks 2 and 4, but at week 8, nizatidine had a significantly higher ulcer healing rate (P=0.036) than cimetidine (86% versus 74%, respectively). Patients with healed ulcers at either week 2 or week 4 had a final endoscopy performed at week 8. The rate of ulcer recurrence was significantly greater (P=0.021) in the cimetidine group at week 8 compared with the nizatidine group: 21% versus 7.3%, respectively. Increasing tolerance to H2receptor antagonist therapy with prolonged use may explain the higher recurrence rate of cimetidine. Both drugs provided equally rapid and effective symptomatic relief from epigastric pain after two weeks of therapy. Both were equally safe and free from treatment-related adverse effects.

Influence of acid and angiogenesis on kinetics of gastric ulcer healing in rats: interaction with indomethacin

1995 ◽  
Vol 268 (2) ◽  
pp. G276-G285 ◽  
Author(s):  
A. Schmassmann ◽  
A. Tarnawski ◽  
B. M. Peskar ◽  
L. Varga ◽  
B. Flogerzi ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Granulation Tissue ◽  
Ulcer Healing ◽  
Healing Rate ◽  
Late Phase ◽  
Gastric Ulcers ◽  
Gastric Ulcer Healing ◽  
Ulcer Healing Rate ◽  
Kinetics Of ◽  
Stimulation Of

Indomethacin delays healing of experimental gastric ulcers. We investigated whether inhibition of gastric acid secretion by omeprazole or stimulation of angiogenesis by basic fibroblast growth factor (bFGF) may reverse this delay. Rats with gastric ulcers induced by cryoprobe were treated subcutaneously with either placebo, indomethacin (2 x 0.5 mg/kg), bFGF (2 x 100 micrograms/kg), omeprazole (1 x 40 mumol/kg), indomethacin plus omeprazole, or indomethacin plus bFGF given daily for 8, 10, 15, and 22 days. Ulcer size, epithelial cell proliferation, angiogenesis, and maturation of granulation tissue were sequentially quantified. Omeprazole significantly accelerated ulcer healing in an early phase (days 3-8). In contrast, bFGF accelerated healing in a late phase (days 10-15). Indomethacin significantly delayed ulcer healing in late phase and decreased prostaglandin generation, cell proliferation, angiogenesis, and maturation of granulation tissue. Despite stimulation of angiogenesis, bFGF did not reverse indomethacin-induced delay in ulcer healing. In contrast, omeprazole reversed indomethacin-induced effects on angiogenesis, cell proliferation, maturation of granulation tissue, and ulcer healing rate.

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