GLYCERYL TRINITRATE HAS MINIMAL EFFECT ON CARDIAC OUTPUT

InPharma ◽  
1979 ◽  
Vol 175 (1) ◽  
pp. 15-15
Keyword(s):  
Cardiac Output ◽  
Glyceryl Trinitrate ◽  
Minimal Effect

Biotransformation of glyceryl trinitrate to glyceryl dinitrate by human hemoglobin

1984 ◽  
Vol 62 (6) ◽  
pp. 704-706 ◽  
Author(s):  
Brian M. Bennett ◽  
Kanji Nakatsu ◽  
James F. Brien ◽  
Gerald S. Marks
Keyword(s):  
Carbon Monoxide ◽  
Cardiac Output ◽  
Glyceryl Trinitrate ◽  
Human Erythrocytes ◽  
Supernatant Fraction ◽  
Human Hemoglobin

The elimination of glyceryl trinitrate (GTN) by man is rapid and its clearance exceeds cardiac output. It is therefore clear that a variety of tissues in addition to liver are involved in the biotransformation of GTN. Incubation of GTN with the 25 000 × g supernatant fraction of lysed human erythrocytes resulted in a 39.6% ± 5.5 (SD) elimination of GTN after 40 min. After pretreatment of the lysate supernatant fraction with carbon monoxide, GTN elimination was only 26% ± 4.5. These data indicated that hemoglobin might be involved in GTN elimination. When purified hemoglobin was incubated with GTN, a 77.1% ± 6.4 elimination of GTN was observed, accompanied by glyceryl dinitrate formation. The biotransformation of GTN was inhibited by pretreatment with carbon monoxide. The results indicate that the biotransformation of GTN by human erythrocytes is due, at least in part, to interaction with hemoglobin.

scholarly journals Myocardial Energy Response to Glyceryl Trinitrate: Physiology Revisited

2021 ◽  
Vol 12 ◽  
Author(s):  
William D. Watson ◽  
Peregrine G. Green ◽  
Ladislav Valkovič ◽  
Neil Herring ◽  
Stefan Neubauer ◽  
...  
Keyword(s):  
Cardiac Output ◽  
Magnetic Resonance ◽  
Glyceryl Trinitrate ◽  
Clinical Medicine ◽  
Left Ventricular ◽  
Forward Rate ◽  
Rate Pressure Product ◽  
Resonance Spectroscopy ◽  
Stroke Work ◽  
Atp Production

Objective: Although intravenous nitrates are commonly used in clinical medicine, they have been shown to increase myocardial oxygen consumption and inhibit complex IV of the electron transport chain. As such we sought to measure whether myocardial energetics were impaired during glyceryl trinitrate (GTN) infusion.Methods: 10 healthy volunteers underwent cardiac magnetic resonance imaging to assess cardiac function and 31phosphorus magnetic resonance spectroscopy to measure Phosphocreatine/ATP (PCr/ATP) ratio and creatine kinase forward rate constant (CK kf) before and during an intravenous infusion of GTN.Results: During GTN infusion, mean arterial pressure (78 ± 7 vs. 65 ± 6 mmHg, p < 0.001), left ventricular (LV) stroke work (7,708 ± 2,782 vs. 6,071 ± 2,660 ml mmHg, p < 0.001), and rate pressure product (7,214 ± 1,051 vs. 6,929 ± 976 mmHg bpm, p = 0.06) all fell. LV ejection fraction increased (61 ± 3 vs. 66 ± 4%, p < 0.001), with cardiac output remaining constant (6.2 ± 1.5 vs. 6.5 ± 1.4 l/min, p = 0.37). Myocardial PCr/ATP fell during GTN infusion (2.17 ± 0.2 vs. 1.99 ± 0.22, p = 0.03) with an increase in both CK kf (0.16 ± 0.07 vs. 0.25 ± 0.1 s−1, p = 0.006) and CK flux (1.8 ± 0.8 vs. 2.6 ± 1.1 μmol/g/s, p = 0.03).Conclusion: During GTN infusion, despite reduced LV stroke work and maintained cardiac output, there was a 44% increase in myocardial ATP delivery through CK. As PCr/ATP fell, this increase in ATP demand coincided with GTN-induced impairment of mitochondrial oxidative phosphorylation. Overall, this suggests that while GTN reduces cardiac work, it does so at the expense of increasing ATP demand beyond the capacity to increase ATP production.

Abstract #330: Insulin Resistance, Cardiac Output and Left Ventricular Mass in Different Degrees of Obesity

2006 ◽  
Vol 12 ◽  
pp. 6-7
Author(s):  
Juan Ybarra ◽  
Josep Maria Pou ◽  
Teresa Doñate ◽  
Monica Isart ◽  
Jaime Pujadas
Keyword(s):  
Insulin Resistance ◽  
Cardiac Output ◽  
Left Ventricular Mass ◽  
Left Ventricular ◽  
Ventricular Mass
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