REDUCTION OF MENSTRUAL BLOOD LOSS BY PROSTAGLANDIN SYNTHETASE INHIBITORS

InPharma ◽  
1976 ◽  
Vol 33 (1) ◽  
pp. 12-12
Keyword(s):  
Blood Loss ◽  
Menstrual Blood ◽  
Menstrual Blood Loss ◽  
Prostaglandin Synthetase

Endometrial prostaglandins and menorrhagia: influence of a prostaglandin synthetase inhibitor in vivo

1987 ◽  
Vol 65 (10) ◽  
pp. 2081-2084 ◽  
Author(s):  
B. K. Tsang ◽  
M. T. Domingo ◽  
J. E. H. Spence ◽  
P. R. Garner ◽  
D. K. Dudley ◽  
...  
Keyword(s):  
Blood Loss ◽  
Mefenamic Acid ◽  
Menstrual Blood ◽  
Etiologic Factor ◽  
Prostaglandin E ◽  
Menstrual Blood Loss ◽  
Prostaglandin Synthetase ◽  
Double Blind ◽  
Prostaglandin F

Prostaglandin levels in the human endometrium were determined on day 2 of the menstrual cycle in eumenorrheic subjects and in patients with menorrhagia, dysmenorrhea, or both. Menorrhagic subjects had significantly higher levels of endometrial prostaglandins of the E and F series when compared with eumenorrheics. Prostaglandin E levels were markedly higher than prostaglandin F. In 10 menorrhagic subjects who completed a double-blind clinical study on the effectiveness of mefenamic acid in lowering menstrual blood loss, 9 exhibited statistically significant reduction in endometrial prostaglandin levels. A decrease in menstrual blood loss was also noted during mefenamic acid treatment in these patients. These findings are consistent with the concept that abnormally high uterine prostaglandin levels may be an important etiologic factor in menorrhagia and support the notion that one of the mechanisms of action of nonsteroidal anti-inflammatory agents in the treatment of this menstrual disorder is inhibition of endometrial prostaglandin production.

REDUCTION OF MENSTRUAL BLOOD-LOSS BY PROSTAGLANDIN-SYNTHETASE INHIBITORS

The Lancet ◽  
1976 ◽  
Vol 307 (7963) ◽  
pp. 774-776 ◽  
Author(s):  
AnneB.M. Anderson ◽  
J. Guillebaud ◽  
P.J. Haynes ◽  
A.C. Turnbull
Keyword(s):  
Blood Loss ◽  
Menstrual Blood ◽  
Menstrual Blood Loss ◽  
Prostaglandin Synthetase

Measurements of menstrual blood loss

1961 ◽  
Vol 81 (4) ◽  
pp. 739-742 ◽  
Author(s):  
Richard M. Baldwin ◽  
P.J. Whalley ◽  
Jack A. Pritchard
Keyword(s):  
Blood Loss ◽  
Menstrual Blood ◽  
Menstrual Blood Loss

Quantitation of menstrual blood loss — Further evaluation of the alkaline hematin method

Contraception ◽  
1972 ◽  
Vol 5 (6) ◽  
pp. 497-513 ◽  
Author(s):  
S.T. Shaw ◽  
D.E. Aaronson ◽  
D.L. Moyer
Keyword(s):  
Blood Loss ◽  
Menstrual Blood ◽  
Menstrual Blood Loss

The influence of a low-dose combined oral contraceptive on menstrual blood loss and iron status

Contraception ◽  
1992 ◽  
Vol 46 (4) ◽  
pp. 327-334 ◽  
Author(s):  
Gerd Larsson ◽  
Lan Milsom ◽  
Göran Lindstedt ◽  
Göran Rybo
Keyword(s):  
Oral Contraceptive ◽  
Blood Loss ◽  
Low Dose ◽  
Iron Status ◽  
Menstrual Blood ◽  
Menstrual Blood Loss ◽  
Combined Oral Contraceptive

Menstrual blood loss with use of a vaginal ring releasing 20 μg levonorgestrel per day

Contraception ◽  
1993 ◽  
Vol 47 (5) ◽  
pp. 455-468 ◽  
Author(s):  
World Health Organization ◽  
Gao Ji ◽  
A.T.L. Andrade ◽  
J.P. Souza ◽  
E. Pizarro-Orchard ◽  
...  
Keyword(s):  
Blood Loss ◽  
Vaginal Ring ◽  
Menstrual Blood ◽  
Menstrual Blood Loss
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