CAUTION WHEN TRANSFERRING TO MONOCOMPONENT INSULIN

InPharma ◽  
1976 ◽  
Vol 33 (1) ◽  
pp. 5-5
Keyword(s):  
Monocomponent Insulin

Insulin-binding antibodies in serum of diabetic children treated with monocomponent insulin

1974 ◽  
Vol 11 (2) ◽  
pp. 165-170 ◽  
Author(s):  
Alicja Symonides-Ławecka ◽  
Halina Ludwiczak ◽  
Henryk Rogala ◽  
January Ławecki ◽  
Artur Czyżyk
Keyword(s):  
Insulin Binding ◽  
Monocomponent Insulin ◽  
Diabetic Children

CLINICAL ASPECTS OF "MONOCOMPONENT" INSULIN IN DIABETES

The Lancet ◽  
1975 ◽  
Vol 306 (7934) ◽  
pp. 548 ◽  
Author(s):  
A.I. Vinik ◽  
W.P.U. Jackson
Keyword(s):  
Clinical Aspects ◽  
Monocomponent Insulin

scholarly journals Proinsulin and A-component antibodies in diabetics after long-term monocomponent insulin treatment

Diabetologia ◽  
1978 ◽  
Vol 14 (3) ◽  
pp. 165-169 ◽  
Author(s):  
B. Bruni ◽  
S. Gamba ◽  
G. Regis ◽  
G. L. Turco
Keyword(s):  
Insulin Treatment ◽  
Monocomponent Insulin

scholarly journals Time-dependence of biological activity induced by covalent insulin-receptor complexes in rat adipocytes

1985 ◽  
Vol 232 (1) ◽  
pp. 49-53 ◽  
Author(s):  
A Schüttler ◽  
C Diaconescu ◽  
D J Saunders ◽  
D Brandenburg
Keyword(s):  
Insulin Receptor ◽  
Inhibitory Effect ◽  
Receptor Complex ◽  
Half Time ◽  
Simple Method ◽  
Receptor Complexes ◽  
Maximal Stimulation ◽  
Monocomponent Insulin ◽  
Specific Receptors ◽  
Stimulation Of

Lipogenesis in isolated adipocyte preparations is stimulated when photosensitive insulin derivatives are attached covalently to specific receptors. This response was compared quantitatively with that to reversibly associated insulin, and it was shown that both covalent and reversible insulin-receptor complexes behave very similarly. The extent of stimulation of lipogenesis was studied as a function of time. Cells were incubated in buffer for various times before addition to vials containing 0 (basal) or 10 ng of monocomponent insulin/ml (maximal) and [U-3H]glucose. After 60 min, the toluene-soluble [3H]lipids were measured. The maximal stimulation induced by reversibly bound insulin was virtually constant over a period of 4 h. In contrast, adipocytes to which N alpha B2-(2-nitro-4-azidophenylacetyl)-des-PheB1-insulin had been covalently attached at the start of the experiment showed a loss of stimulation with time when incubated at 37 degrees C. This loss was decreased in the presence of lysosomotropic agents such as chloroquine at concentrations (approx. 200 microM) that had very little or no effect on the basal and maximal lipogenesis rates. A simple method was used to transform the measured rate of loss of stimulation into a rate of loss of effective units. A half-time of 80 min was calculated for the effective covalent insulin-receptor units in adipocytes at 37 degrees C at pH 7.4. This is very close to values reported by others for the internalization of covalent complexes in these cells, suggesting that this may be the causative event for the deactivation of the insulin-receptor unit. The inhibitory effect of chloroquine on the deactivation may indicate that the insulin-receptor complex can function even after internalization.

scholarly journals Serum levels of insulin-binding antibodies in diabetic patients treated with monocomponent insulin

Diabetologia ◽  
1974 ◽  
Vol 10 (3) ◽  
pp. 233-236 ◽  
Author(s):  
A. Czyżyk ◽  
J. Ławecki ◽  
H. Rogala ◽  
E. Miedzińska ◽  
A. Popik-Hankiewicz
Keyword(s):  
Insulin Binding ◽  
Serum Levels ◽  
Diabetic Patients ◽  
Monocomponent Insulin

Generalised allergy to porcine and bovine monocomponent insulin

BMJ ◽  
1981 ◽  
Vol 282 (6257) ◽  
pp. 75-75 ◽  
Author(s):  
J Mellowes
Keyword(s):  
Monocomponent Insulin

scholarly journals Local cutaneous allergy to monocomponent insulin.

1979 ◽  
Vol 55 (641) ◽  
pp. 199-200 ◽  
Author(s):  
D. Q. Borsey ◽  
D. N. Malone
Keyword(s):  
Monocomponent Insulin
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