WHAT HAPPENS TO FENOTEROL HYDROBROMIDE WHEN GIVEN BY AEROSOL?

InPharma ◽  
1977 ◽  
Vol 108 (1) ◽  
pp. 14-14
Keyword(s):  
Fenoterol Hydrobromide

scholarly journals Fenoterol did not enhance glucocorticoid-induced skeletal changes in male rats.

2011 ◽  
Vol 58 (3) ◽  
Author(s):  
Joanna Folwarczna ◽  
Barbara Nowińska ◽  
Leszek Śliwiński ◽  
Maria Pytlik ◽  
Urszula Cegieła ◽  
...  
Keyword(s):  
Mature Male ◽  
Male Rats ◽  
Femoral Diaphysis ◽  
Skeletal System ◽  
Concurrent Administration ◽  
Skeletal Changes ◽  
Bone Changes ◽  
Male Wistar Rats ◽  
Turnover Markers ◽  
Fenoterol Hydrobromide

Glucocorticoids and β(2)-adrenergic receptor agonists are the most commonly used drugs in the treatment of asthma. Both therapies are potentially dangerous to the skeletal system. The aim of the present study was to investigate the effects of fenoterol, a β(2)-receptor agonist, on the development of bone changes induced by glucocorticoid (prednisolone) administration in mature male rats. The experiments were carried out on 24-week-old male Wistar rats. The effects of prednisolone 21-hemisuccinate sodium salt (7 mg/kg s.c. daily) or/and fenoterol hydrobromide (1.4 mg/kg i.p. daily), administered for 4 weeks, on the skeletal system were studied. Bone turnover markers, geometric parameters, mass, mass of bone mineral in the tibia, femur and L-4 vertebra, bone histomorphometric parameters and mechanical properties of tibial metaphysis, femoral diaphysis and femoral neck were determined. Both prednisolone and fenoterol had damaging effects on the skeletal system of mature male rats. However, concurrent administration of fenoterol and prednisolone did not result in the intensification of the deleterious skeletal effect of either drug administered separately.

scholarly journals Fenoterol hydrobromide delivered via HFA-MDI or CFC-MDI in patients with asthma: a safety and efficacy comparison

2000 ◽  
Vol 94 (10) ◽  
pp. 948-953 ◽  
Author(s):  
J. GOLDBERG ◽  
W. BÖHNING ◽  
P. SCHMIDT ◽  
E. FREUND
Keyword(s):  
Safety And Efficacy ◽  
Fenoterol Hydrobromide
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