Side effects of intravenous glyceryl trinitrate

Reactions ◽  
1984 ◽  
Vol 91 (1) ◽  
pp. 9-10
Keyword(s):  
Side Effects ◽  
Glyceryl Trinitrate ◽  
Intravenous Glyceryl Trinitrate

scholarly journals ANAL FISSURE;

2008 ◽  
Vol 15 (04) ◽  
pp. 420-424
Author(s):  
AZEEM HASHMAT ◽  
TAHIRA ` ISHFAQ
Keyword(s):  
Clinical Trial ◽  
Side Effects ◽  
Glyceryl Trinitrate ◽  
Anal Fissure ◽  
Healing Rate ◽  
Anal Verge ◽  
Prospective Clinical Trial ◽  
Fissure In Ano ◽  
Presenting Symptoms

Objective: To evaluate the efficacy of glyceryl trinitrate (GTN) preparation for the treatment fissure in-ano. Design: This studyis a prospective clinical trial. Place and duration: this was conducted initially at PMC Faisalabad and other centers from November 2001 toonward for the period of five years. Patients and Methods: Out of 306 patients, 42 disliked/ refused this modality of treatment and waslaunched on 264 patients. 114 patients never followed up so, were excluded from the study. The remaining 276 patients applied 0.2% glyceryltrinitrate preparation on their anal verge thrice a day for two months. The patients were followed up at 1 to 12 weeks. The extent of st thimprovement in the presenting symptoms, side effects and complications were noted on questionnaires. Results: A healing rate of 64.3%, andrecurrence occurred in 35.7 %. 72 patients demanded surgery after failure/ non-compliance of GTN ointment treatment. Conclusion: glyceryltrinitrate preparation is a safe and effective modality for the treatment of fissure in-ano.

scholarly journals Comparative evaluation of 5% lignocaine ointment and a combination of 0.2% glyceryl trinitrate and 5% lignocaine in management of acute fissure in ano.

2017 ◽  
Vol 4 (9) ◽  
pp. 3113
Author(s):  
Vundavalli Sattibabu ◽  
Satish Dalal ◽  
Mahavir Singh ◽  
Chisel Bhatia
Keyword(s):  
Side Effects ◽  
Glyceryl Trinitrate ◽  
Anal Fissure ◽  
Treatment Options ◽  
Common Symptom ◽  
Outpatient Basis ◽  
Fissure In Ano ◽  
Aged Patients ◽  
Group I ◽  
Wide Range

Background: Anal fissure is one of the most common anorectal problem and presents as a tear in the anoderm distal to the dentate line. It is a common proctologic problem and accounts for 10-15% of proctological consultations and seen frequently in young and middle-aged patients. Presently wide range of medical and surgical treatment options were available. Present study was aimed to evaluate the therapeutic efficacy of 5% lignocaine ointment and a combination of 0.2% glyceryl trinitrate and 5% lignocaine in management of acute fissure in ano.Methods: In the present study, a total of 100 patients diagnosed with acute fissure in ano were randomly allocated into two groups (I, II) of 50 patients each and were managed by local application of 5% Lignocaine (LIG) ointment and a combination of both 0.2% Glyceryl trinitrate (NTG) and 5% Lignocaine (LIG) ointment respectively.Results: In the present study, the incidence of anal fissure was higher in males than in females with mean age of occurrence of 35.12 years. Pain was the most common symptom to present with. After six weeks, complete pain relief was seen in most of the patients and was comparable in both the groups but healing was superior in group II when compared to group I. Headache and dizziness were the side effects only noticed in group II.Conclusions: To conclude the study, we can say that the treatment of anal fissure is becoming increasingly medical as it can be carried out on outpatient basis and is cost effective and there is no loss of man hours. Lignocaine may be preferred as the first line treatment as there are no side effects and if there is failure to heal then we can prescribe the combination of both drugs owing to their risk benefit ratio.

Effectiveness and Complications of 0.2% Glyceryl Trinitrate in the Treatment of Chronic Anal Fissure

1970 ◽  
Vol 25 (1) ◽  
pp. 14-17 ◽  
Author(s):  
KM Murshed ◽  
MI Siddique ◽  
MA Rahman
Keyword(s):  
Side Effects ◽  
Pain Relief ◽  
Glyceryl Trinitrate ◽  
Anal Fissure ◽  
Chronic Anal Fissure ◽  
Symptom Relief ◽  
Major Side Effect ◽  
Primary Focus ◽  
A Prospective Study

Background: The aim of this study was to analyze the effectiveness and morbidity of chemical sphincterotomy by 0.2% glyceryl trinitrate (GTN) in the treatment of chronic anal fissure. The main end points were symptom relief, fissure healing and side effects. Methods: A prospective study was conducted to see the effectiveness and side effects of 0.2% glyceryl trinitrate in the treatment of patients with chronic anal fissure attending the outpatient department of surgery from February 2004 to the end of February 2005. All the patients were followed up at 2 weeks interval for 8 weeks. The primary focus was fissure healing and the secondary focus were on improvement of symptoms, need for surgical sphincterotomy and side effects. Results: One hundred and twenty two adult patients, both male and female with chronic anal fissure were treated with local application of 0.2% glyceryl trinitrate. Pain relief occurred earlier than fissure healing. At the end of 8 weeks treatment about two third of the total patients got complete pain relief and fissure healing. Headache was the major side effect. Conclusion: Topical application of 0.2% glyceryl trinitrate (GTN) should be the initial treatment of choice for chronic anal fissure to avoid the long term complication of incontinence following surgical sphincterotomy. (J Bangladesh Coll Phys Surg 2007; 25 : 14-17)

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