Oral antihyperglycaemic agent utilisation in drug-insured US

2001 ◽  
Vol 329 (1) ◽  
pp. 9-9
Keyword(s):  
Antihyperglycaemic Agent ◽  
Oral Antihyperglycaemic Agent

Repeated Administration of SL 84.0418, a New Oral Antihyperglycaemic Agent

1995 ◽  
Vol 9 (4) ◽  
pp. 191-196
Author(s):  
F. De Ponti ◽  
F. Crema ◽  
L. DʼAngelo ◽  
M. Caravaggi ◽  
G. Broccali ◽  
...  
Keyword(s):  
Repeated Administration ◽  
Antihyperglycaemic Agent ◽  
Oral Antihyperglycaemic Agent

scholarly journals Electrochemical stability of metformin in NaHCO3 and Na2SO4 water solution at Au, GC and IrOx electrodes

2019 ◽  
Vol 84 (11) ◽  
pp. 1319-1327
Author(s):  
Jelena Lovic ◽  
Jelena Ladjarevic ◽  
Dusan Mijin ◽  
Milka Jadranin ◽  
Slobodan Petrovic ◽  
...  
Keyword(s):  
Square Wave Voltammetry ◽  
Water Solution ◽  
Uv Spectroscopy ◽  
Sodium Sulphate ◽  
Electrochemical Stability ◽  
Electrochemical Processes ◽  
Wave Voltammetry ◽  
Oral Antihyperglycaemic Agent ◽  
The Stability ◽  
Total Organic Carbon Analysis

In this study the electrochemical behavior of metformin (MET), oral antihyperglycaemic agent, was assayed at three different electrodes. The drug standard was investigated by cyclic voltammetry and square wave voltammetry via its electrooxidation at Au and glassy carbon electrode in 0.05 M NaHCO3. Under these conditions transformation of MET to corresponding N-carbonyl guanidine via oxime intermediate is suggested. The stability of MET was tested under directed stress conditions using IrOx electrode with sodium sulphate as an electrolyte and cyclic 4-amino-2-imino-1-methyl-1,2-dihydro-1,3,5-triazine appeared as the main end-product. The courses of the electrochemical processes at three electrodes were followed by UV spectroscopy and evaluated by total organic carbon analysis.

The synthesis of BRL 49653 - a novel and potent antihyperglycaemic agent

1994 ◽  
Vol 4 (10) ◽  
pp. 1181-1184 ◽  
Author(s):  
Barrie C.C. Cantello ◽  
Michael A. Cawthorne ◽  
David Haigh ◽  
Richard M. Hindley ◽  
Stephen A. Smith ◽  
...  
Keyword(s):  
Antihyperglycaemic Agent
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